Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 30 197 2012 08 22 Mechanisms of Chemoresistance in Tumor-Derived Cancer Stem Cells Mechanisms of Chemoresistance in Tumor-Derived Cancer Stem Cells 13842 FA Hamid Reza Mirzaei Biotechnology Research Center, AJA University of Medical Sciences, Tehran, AND Department of Medical Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Marjan Gharagozloo Assistant Professor, Department of Medical Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Abbas Rezaei Professor, Department of Medical Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Mohammad Soleimani Assistant Professor, Biotechnology Research Center, AJA University of Medical Sciences, Tehran, Iran Hamid Kalantari Associate Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Hamed Mirzaei Department of Biotechnology, School of Basic Sciences, Karaj Payam Noor University, Karaj, Iran Mohammad Eghbali Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran Mohsen Chamanara Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran Mohammadhasan Tajadini Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Journal Article 2012 05 27 The existence of cancer stem cells (CSCs) has been already established in several hematopoietic and non-hematopoietic cancers. Chemoresistance has also been demonstrated as a major cause of cancer treatment failure. Although chemotherapy kills most cells in a tumor, it is believed to leave CSCs behind which might be an important mechanism of resistance and thereby cancer treatment failure. The quiescent nature and existence of adenosine triphosphate (ATP)-binding cassette (ABC) drug transporters in CSCs have been suggested to protect them from chemotherapeutic agents. Gaining a better insight into the mechanisms of CSCs chemoresistance might therefore lead to new therapeutic targets and development of better anticancer strategies. Keywords: Cancer stem cells, Chemotherapy, Drug resistance. The existence of cancer stem cells (CSCs) has been already established in several hematopoietic and non-hematopoietic cancers. Chemoresistance has also been demonstrated as a major cause of cancer treatment failure. Although chemotherapy kills most cells in a tumor, it is believed to leave CSCs behind which might be an important mechanism of resistance and thereby cancer treatment failure. The quiescent nature and existence of adenosine triphosphate (ATP)-binding cassette (ABC) drug transporters in CSCs have been suggested to protect them from chemotherapeutic agents. Gaining a better insight into the mechanisms of CSCs chemoresistance might therefore lead to new therapeutic targets and development of better anticancer strategies. Keywords: Cancer stem cells, Chemotherapy, Drug resistance. https://jims.mui.ac.ir/article_13842_ebd58b8a3f1d72f4206201da62fb1204.pdf