Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 32 320 2015 02 20 Effects of Resvin Supplement on the levels of Interleukin-6 and C-Reactive Protein and Insulin Resistance in Women with Type 2 Diabetes Effects of Resvin Supplement on the levels of Interleukin-6 and C-Reactive Protein and Insulin Resistance in Women with Type 2 Diabetes 2484 2490 14549 FA Ensiyeh Yazdekhasti Department of Sport Sciences, School of Humanities, Arak University, Arak, Iran Nader Shavandi Associate Professor, Department of Sport Sciences, School of Humanities, Arak University, Arak, Iran Ahmad Mahmoudian Associate Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Abbas Saremi Assistant Professor, Department of Sport Sciences, School of Humanities, Arak University, Arak, Iran Journal Article 2015 03 19 Background: Inflammation increases the complications of diabetes mellitus. Antioxidants can reduce inflammation. Interleukin-6 (IL-6) and C-reactive protein (CRP) are inflammatory factors, and the question is whether the Resvin, as an antioxidant, can reduce the levels of both and impact on insulin resistance?Methods: In this semi-experimental study, with pre-test and post-test design, 16 women with type 2 diabetes were randomly assigned to two equal groups of intervention (mean age: 59.25 ± 5.11 years) and control (mean age: 52.25 ± 10.60 years). Subjects in the intervention group received 400 mg of Resvin supplements daily for 6 weeks. Blood samples were taken for determination of IL-6 and CRP levels and the insulin resistance, before and after the intervention.Finding: After 6 weeks of receiving Resvin supplementation, CRP and IL-6 levels significantly decreased in the intervention group (P < 0.05). Insulin resistance improved significantly, too (P < 0.05).Conclusion: Based on the findings, Resvin supplementation may reduce the inflammatory markers and insulin resistance in women with type 2 diabetes.  Background: Inflammation increases the complications of diabetes mellitus. Antioxidants can reduce inflammation. Interleukin-6 (IL-6) and C-reactive protein (CRP) are inflammatory factors, and the question is whether the Resvin, as an antioxidant, can reduce the levels of both and impact on insulin resistance?Methods: In this semi-experimental study, with pre-test and post-test design, 16 women with type 2 diabetes were randomly assigned to two equal groups of intervention (mean age: 59.25 ± 5.11 years) and control (mean age: 52.25 ± 10.60 years). Subjects in the intervention group received 400 mg of Resvin supplements daily for 6 weeks. Blood samples were taken for determination of IL-6 and CRP levels and the insulin resistance, before and after the intervention.Finding: After 6 weeks of receiving Resvin supplementation, CRP and IL-6 levels significantly decreased in the intervention group (P < 0.05). Insulin resistance improved significantly, too (P < 0.05).Conclusion: Based on the findings, Resvin supplementation may reduce the inflammatory markers and insulin resistance in women with type 2 diabetes.  https://jims.mui.ac.ir/article_14549_d111f133fa0ea545d48291f9b0a72b2d.pdf