Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 34 372 2016 03 20 Obesity and Inflammation: Role of Adipokines Obesity and Inflammation: Role of Adipokines 148 156 14887 FA Majid Khazaei Associate Professor, Neurogenic Inflammation Research Centre AND Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Reza Rouzbahani Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Journal Article 2015 04 27 Because of the growing epidemic of obesity worldwide and its complications, understanding the function and secreted substances of adipose tissue and their effects on the body is very important. Obesity is characterized by what is called chronic low-grade inflammation which may be involved in pathogenesis of obesity-related complications. Adipose tissue releases multiple bioactive substances known as adipokines which have pro or anti-inflammatory actions. It is suggested that imbalances between production and secretion of adipokines during obesity can contribute to obesity-related complications. In this review, we discuss about inflammation during obesity and the role of adipokines in this process. Because of the growing epidemic of obesity worldwide and its complications, understanding the function and secreted substances of adipose tissue and their effects on the body is very important. Obesity is characterized by what is called chronic low-grade inflammation which may be involved in pathogenesis of obesity-related complications. Adipose tissue releases multiple bioactive substances known as adipokines which have pro or anti-inflammatory actions. It is suggested that imbalances between production and secretion of adipokines during obesity can contribute to obesity-related complications. In this review, we discuss about inflammation during obesity and the role of adipokines in this process. https://jims.mui.ac.ir/article_14887_df6af7afd03086cd9331f08187159a9a.pdf