Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 34 379 2016 05 21 Chronic Low-Grade Inflammation: Etiology and its Effects Chronic Low-Grade Inflammation: Etiology and its Effects 408 421 14929 FA Fereshteh Asgharzadeh MSc Student, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Reza Rouzbahani Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Majid Khazaei Professor, Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 0000-0002-7979-5699 Journal Article 2015 10 18 Chronic low-grade inflammation is a Para-clinical finding in several diseases including obesity, diabetes, nervous diseases and etc. Numerous studies have been done to determine the causes and effects of low-grade inflammation on the body. Today, chronic low-grade inflammation is considered in pathogenesis of these diseases. Chronic inflammation is reflected by increased circulating levels of gram-negative bacterial endotoxin lipopolysaccharide (LPS) which is associated by high level of inflammatory markers. Numerous factors can be involved in induction and progression of low-grade inflammation which lead to some consequences on different parts of body. In this review, we aimed to discuss about the causes and consequences of low-grade inflammation. Chronic low-grade inflammation is a Para-clinical finding in several diseases including obesity, diabetes, nervous diseases and etc. Numerous studies have been done to determine the causes and effects of low-grade inflammation on the body. Today, chronic low-grade inflammation is considered in pathogenesis of these diseases. Chronic inflammation is reflected by increased circulating levels of gram-negative bacterial endotoxin lipopolysaccharide (LPS) which is associated by high level of inflammatory markers. Numerous factors can be involved in induction and progression of low-grade inflammation which lead to some consequences on different parts of body. In this review, we aimed to discuss about the causes and consequences of low-grade inflammation. https://jims.mui.ac.ir/article_14929_5243958a762063341dc82d2bbf0f5f33.pdf