Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 35 440 2017 08 23 Impact of Cranberry Juice Enriched With Omega-3 and Their Individual Consumption Adjunct with Nonsurgical Periodontal Treatment on Glycemic Control and Lipid Profile in Patients with Diabetes Mellitus and Periodontal Disease Impact of Cranberry Juice Enriched With Omega-3 and Their Individual Consumption Adjunct with Nonsurgical Periodontal Treatment on Glycemic Control and Lipid Profile in Patients with Diabetes Mellitus and Periodontal Disease 919 926 15311 FA Ahmad Zare-Javid Assistant Professor, Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Elnaz Ashrafzadeh MSc Student, Department of Nutrition, School of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Iran Hosein Babaee Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Hojatallah Yousefimanesh Assistant Professor, Department of Periodontology, School of Dentistry , Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mehrnoosh Zakerkish Assistant Professor, Department of Endocrinology, Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Kambiz Ahmadi-Angali Assistant Professor, Department of Biostatistics, School of Public Health AND Social Determinants of Research Center Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Gholamreza Asgari Assistant Professor, Department of Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran Journal Article 2014 05 06 Background: Periodontal disease, a common widespread chronic disease, is considered as an important complication in diabetes. The aim of this study was to evaluate the effects of cranberry juice enriched with omega-3 and their individual consumption on glycemic control and lipid profile in patients with diabetes mellitus and periodontal disease.Methods: In this randomized clinical trial study, 41 patients with diabetes mellitus and chronic adult periodontal disease were randomly assigned to one group of control (n = 12) and three groups of intervention receiving omega-3 (n = 10), cranberry juice (n = 9), and cranberry juice enriched with omega-3 (n = 10) for 8 weeks. Nonsurgical periodontal therapy was provided for all the patients during the study. Fasting blood glucose, glycosylated hemoglobin A, and lipid profile were measured at baseline and at the end of the study.Findings: There was significant reduction in glycosylated hemoglobin A observed in intervention groups of receiving omega-3 (11%, P = 0.017) and cranberry enriched with omega-3 (7%, P = 0.014). The intervention group receiving omega-3 had significantly lower glycosylated hemoglobin A compared with control group. Furthermore, the intervention group receiving cranberry juice enriched with omega-3 had significantly higher high-density lipoprotein cholesterol (HDL-C) than the other intervention groups. There were no significant differences found in fasting blood sugar (FBS), triglyceride (TG), total cholesterol and Low-density lipoprotein cholesterol (LDL-C) between and within the groups.Conclusion: It is suggested that consumption of cranberry juice enriched with omega-3 as a nutritional approach in adjunct with nonsurgical periodontal therapy may help to improve glycemic control and lipid profile in patients with diabetes mellitus and periodontal disease. Background: Periodontal disease, a common widespread chronic disease, is considered as an important complication in diabetes. The aim of this study was to evaluate the effects of cranberry juice enriched with omega-3 and their individual consumption on glycemic control and lipid profile in patients with diabetes mellitus and periodontal disease.Methods: In this randomized clinical trial study, 41 patients with diabetes mellitus and chronic adult periodontal disease were randomly assigned to one group of control (n = 12) and three groups of intervention receiving omega-3 (n = 10), cranberry juice (n = 9), and cranberry juice enriched with omega-3 (n = 10) for 8 weeks. Nonsurgical periodontal therapy was provided for all the patients during the study. Fasting blood glucose, glycosylated hemoglobin A, and lipid profile were measured at baseline and at the end of the study.Findings: There was significant reduction in glycosylated hemoglobin A observed in intervention groups of receiving omega-3 (11%, P = 0.017) and cranberry enriched with omega-3 (7%, P = 0.014). The intervention group receiving omega-3 had significantly lower glycosylated hemoglobin A compared with control group. Furthermore, the intervention group receiving cranberry juice enriched with omega-3 had significantly higher high-density lipoprotein cholesterol (HDL-C) than the other intervention groups. There were no significant differences found in fasting blood sugar (FBS), triglyceride (TG), total cholesterol and Low-density lipoprotein cholesterol (LDL-C) between and within the groups.Conclusion: It is suggested that consumption of cranberry juice enriched with omega-3 as a nutritional approach in adjunct with nonsurgical periodontal therapy may help to improve glycemic control and lipid profile in patients with diabetes mellitus and periodontal disease. https://jims.mui.ac.ir/article_15311_e3d3df46b70f76b21404bf38e34f3802.pdf