Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 36 472 2018 04 21 Comparison of the Premedication Effect of Propofol and Dexamethasone on Reducing Fentanyl-Induced Cough Comparison of the Premedication Effect of Propofol and Dexamethasone on Reducing Fentanyl-Induced Cough 251 256 15524 10.22122/jims.v36i472.8787 FA Reihanak Talakoub Associate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0002-0212-3608 Anahita Hirmanpour Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0003-0574-2831 Parisa Jalilianfar Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Tahereh Gholamzadeh Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Journal Article 2017 09 12 Background: The incidence of fentanyl-induced cough (FIC) during induction of general anesthesia is 28-65%. Therefore, prevention of this complication is required. In this study, the effects of propofol and dexamethasone on the frequency and severity of fentanyl-induced cough were assessed in patients undergoing general anesthesia.Methods: During a double-blind, randomized clinical trial study, 99 patients aged 18-64 years with classes I and II of American Society of Anesthesiologists (ASA) classification, who were undergoing general anesthesia with fentanyl, were investigated. Patients were randomly divided equally into 3 groups receiving propofol (1.5 mg/kg), dexamethasone (0.1 mg/kg), and placebo (5 ml normal saline). All drugs were administered 1 minute before administration of 2.5 µg/kg fentanyl. Vital signs, and frequency and intensity of cough were measured and recorded. Statistical analysis was performed using one-way ANOVA and Kruskal-wallis tests.Findings: The incidence of fentanyl-induced cough was 27.3%, 78.8%, and 84.8% in propofol, dexamethasone, and placebo groups, respectively (P< 0.010). The severity of cough was significantly lower in the propofol group (mild: 72.7%, moderate: 27.3%, and severe: 0%) compared to the placebo group (mild: 18.2%, moderate: 72.7%, and severe: 9.1%) (P < 0.010). Furthermore, there were significant differences between three groups in the variations of hemodynamic parameters (P < 0.050).Conclusion: It seems that administration of low-dose propofol (10 mg) can reduce the frequency and intensity of fentanyl-induced cough during induction of general anesthesia. Background: The incidence of fentanyl-induced cough (FIC) during induction of general anesthesia is 28-65%. Therefore, prevention of this complication is required. In this study, the effects of propofol and dexamethasone on the frequency and severity of fentanyl-induced cough were assessed in patients undergoing general anesthesia.Methods: During a double-blind, randomized clinical trial study, 99 patients aged 18-64 years with classes I and II of American Society of Anesthesiologists (ASA) classification, who were undergoing general anesthesia with fentanyl, were investigated. Patients were randomly divided equally into 3 groups receiving propofol (1.5 mg/kg), dexamethasone (0.1 mg/kg), and placebo (5 ml normal saline). All drugs were administered 1 minute before administration of 2.5 µg/kg fentanyl. Vital signs, and frequency and intensity of cough were measured and recorded. Statistical analysis was performed using one-way ANOVA and Kruskal-wallis tests.Findings: The incidence of fentanyl-induced cough was 27.3%, 78.8%, and 84.8% in propofol, dexamethasone, and placebo groups, respectively (P< 0.010). The severity of cough was significantly lower in the propofol group (mild: 72.7%, moderate: 27.3%, and severe: 0%) compared to the placebo group (mild: 18.2%, moderate: 72.7%, and severe: 9.1%) (P < 0.010). Furthermore, there were significant differences between three groups in the variations of hemodynamic parameters (P < 0.050).Conclusion: It seems that administration of low-dose propofol (10 mg) can reduce the frequency and intensity of fentanyl-induced cough during induction of general anesthesia. https://jims.mui.ac.ir/article_15524_d12e9ce9949f610ac6075ea1edbade93.pdf