Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 39 626 2021 07 23 Vitamin D Level in Iranian Patients with Neuromyelitis Optica Vitamin D Level in Iranian Patients with Neuromyelitis Optica 370 375 16200 10.22122/jims.v39i626.14064 FA Azar Baradaran Professor, Department of Pathology, School of Medicine AND Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0001-7058-6367 Omid Mirmosayyeb General Practitioner, Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Ira 0000-0002-3756-2985 Vahid Shaygannejad Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0002-6226-0161 Azar Naimi Assistant Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0002-7717-9112 Alireza Afshari-Safavi Assistant Professor, Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran 0000-0002-2080-946X Zahra Taji Student of Medicine, Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0001-9550-8816 Journal Article 2021 04 20 Background: Neuromyelitis optica is one of the inflammatory diseases of the central nervous system (CNS) that causes demyelination and axonal injury, especially in optic nerve and spinal cord. Considering the immunoregulatory function of vitamin D, deficiency of this vitamin may play a role in the pathogenesis as well as the severity of neuromylitis optica. The aim of this study was to compare the serum level of vitamin D in patients with neuromylitis optica and control group, and to investigate the relationship between the level of this vitamin and disability and number of attacks during the year in these patients.Methods: In this cross-sectional study, 40 patients with neuromylitis optica and 40 healthy individuals as a control group participated. Serum level of 25 (OH) vitamin D was measured using high-performance liquid chromatography (HLPC) method and compared. Clinical parameters such as Expanded Disability Status Scale (EDSS) and Annualized Relapse Rate (ARR) were also evaluated in patients.Findings: The median of serum levels of vitamin D was higher in patients (46.2 ng/ml) than in controls (29.65 ng/ml) (P < 0.001). The prevalence of Vitamin D insufficiency in the control group (52.5%) was higher than this prevalence in patients (5.0%). Moreover, there was no significant relationship between serum vitamin D levels with body mass index (BMI), EDSS, and ARR in patients.Conclusion: According to our findings, there was no significant association between vitamin D deficiency and neuromylitis optica disease. Background: Neuromyelitis optica is one of the inflammatory diseases of the central nervous system (CNS) that causes demyelination and axonal injury, especially in optic nerve and spinal cord. Considering the immunoregulatory function of vitamin D, deficiency of this vitamin may play a role in the pathogenesis as well as the severity of neuromylitis optica. The aim of this study was to compare the serum level of vitamin D in patients with neuromylitis optica and control group, and to investigate the relationship between the level of this vitamin and disability and number of attacks during the year in these patients.Methods: In this cross-sectional study, 40 patients with neuromylitis optica and 40 healthy individuals as a control group participated. Serum level of 25 (OH) vitamin D was measured using high-performance liquid chromatography (HLPC) method and compared. Clinical parameters such as Expanded Disability Status Scale (EDSS) and Annualized Relapse Rate (ARR) were also evaluated in patients.Findings: The median of serum levels of vitamin D was higher in patients (46.2 ng/ml) than in controls (29.65 ng/ml) (P < 0.001). The prevalence of Vitamin D insufficiency in the control group (52.5%) was higher than this prevalence in patients (5.0%). Moreover, there was no significant relationship between serum vitamin D levels with body mass index (BMI), EDSS, and ARR in patients.Conclusion: According to our findings, there was no significant association between vitamin D deficiency and neuromylitis optica disease. https://jims.mui.ac.ir/article_16200_5e1f128ae6bd71960aa75fdd584b9db5.pdf