Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 39 644 2021 11 22 Clinical Complications and Laboratory Disturbances Following Administration of Intravenous Immunoglobulin (IVIG) in hospitalized Children in Imam Hossein Hospital, Isfahan, Iran, in Years 2018-2019 Clinical Complications and Laboratory Disturbances Following Administration of Intravenous Immunoglobulin (IVIG) in hospitalized Children in Imam Hossein Hospital, Isfahan, Iran, in Years 2018-2019 744 748 16254 10.22122/jims.v39i644.14500 FA Rasool Kermani Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0003-3270-3432 Tooba Momen Associate Professor, Department of Allergy and Clinical Immunology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0001-6302-8420 Mehryar Mehrkash Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0001-6418-5743 Meysam Barzegar Bafruei Student of Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0002-7371-419X Journal Article 2021 08 31 Background: Intravenous immunoglobulin (IVIG) is a product isolated from the plasma of donors. Laboratory variations are one of the complications of this product. The goal of this study was to evaluate the adverse effects and laboratory variations in children receiving IVIG.\Methods: This retrospective cross-sectional study was conducted by studying the file records of all admitted patients receiving IVIG in Imam Hossein Hospital, Isfahan, Iran, in years 2018-2019. Then, all registering data in collection form were entered into SPSS software, and relevant analysis was performed.Findings: Serum sodium, potassium, and hemoglobin reduced significantly. Blood urea nitrogen (BUN) level increased after infusion. However, changes in albumin and creatinine were not statistically significant. 3 patients (16.67%) developed fever, chills, and headache after infusion. No reduction in urinary output, or acute renal failure was observed in any of patients.Conclusion: The laboratory variations are not clinically dangerous in patients. Follow-up tests are not routinely recommended for all patients. Background: Intravenous immunoglobulin (IVIG) is a product isolated from the plasma of donors. Laboratory variations are one of the complications of this product. The goal of this study was to evaluate the adverse effects and laboratory variations in children receiving IVIG.\Methods: This retrospective cross-sectional study was conducted by studying the file records of all admitted patients receiving IVIG in Imam Hossein Hospital, Isfahan, Iran, in years 2018-2019. Then, all registering data in collection form were entered into SPSS software, and relevant analysis was performed.Findings: Serum sodium, potassium, and hemoglobin reduced significantly. Blood urea nitrogen (BUN) level increased after infusion. However, changes in albumin and creatinine were not statistically significant. 3 patients (16.67%) developed fever, chills, and headache after infusion. No reduction in urinary output, or acute renal failure was observed in any of patients.Conclusion: The laboratory variations are not clinically dangerous in patients. Follow-up tests are not routinely recommended for all patients. https://jims.mui.ac.ir/article_16254_7464d29c8432f9d1590f037f0972dd0b.pdf