Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 42 755 2024 03 20 Comparison of the Effectiveness of Vitamin D, Integrated Cognitive Rehabilitation Therapy, Transcranial Alternating Current Stimulation on Depression in Patients with Mild Cognitive Impairment Comparison of the Effectiveness of Vitamin D, Integrated Cognitive Rehabilitation Therapy, Transcranial Alternating Current Stimulation on Depression in Patients with Mild Cognitive Impairment 58 68 31130 10.48305/jims.v42.i755.0058 FA Fariba Ebrahimbabaie PhD Student, Department of Psychology, School of Literature and Humanities’Sciences, Lorestan University, Lorestan, Iran 0000-0001-9024-7178 Kourosh Amraei Associate Professor, Department of Psychology, School of Literature and Humanities’Sciences, Lorestan University, Lorestan, Iran 0000-0001-6634-5261 Firoozeh Ghazanfari Professor, Department of Psychology, School of Literature and Humanities’Sciences, Lorestan University, Lorestan, Iran 0000-0002-1746-5045 Parisa Taheri Tanjani Associate Professor, Department of Internal Medicine, Ayatollah Taleghani Hospital, Research Development Unit, Shahid Beheshti University of Medical Sciences, Tehran, Iran 0000-0001-5616-6569 Journal Article 2023 08 19 Background: Depression is a predictor of cognitive impairment in aged people. This study aimed to compare the effect of Vitamin D, integrated cognitive rehabilitation therapy (CRT), transcranial alternating current stimulation (tACS), and a combination of CRT and tACS on depression in patients with mild cognitive impairment (MCI). Methods: The present study is a semi-experimental clinical trial study in which 32 people with mild cognitive impairment were randomly assigned to four treatment groups after completing the Beck Depression Test and the Mocha Test. CRT, tACS, and CRT + tACS interventions were held twice a week for 12 sessions each. Each session of CRT and tACS lasted 20 minutes, and each session of cognitive rehabilitation treatment plus TACS was performed for 40 minutes, and the group receiving vitamin D; received 20 micrograms equivalent to 800 IU of vitamin D daily for six weeks. Before conducting the research, the Beck depression test (BDI) and MoCA test were taken, and at the end of the research, BDI was taken to check the effectiveness of treatments on reducing depression. To analyze the results, the repeated measurement statistical test with a significance level of less than 0.05 was used. Findings: The results showed that the depression scores decreased significantly in the cognitive rehabilitation intervention group from 11 to 9. However, no significant difference was observed in the transcranial alternating current stimulation (tACS) and combination of CRT and tACS and vitamin D groups. Conclusion: According to the present study, CRT decreased depression scores in MCI, and it is more effective in reducing depression compared to tACS, CRT+tACS, and vitamin D. Background: Depression is a predictor of cognitive impairment in aged people. This study aimed to compare the effect of Vitamin D, integrated cognitive rehabilitation therapy (CRT), transcranial alternating current stimulation (tACS), and a combination of CRT and tACS on depression in patients with mild cognitive impairment (MCI). Methods: The present study is a semi-experimental clinical trial study in which 32 people with mild cognitive impairment were randomly assigned to four treatment groups after completing the Beck Depression Test and the Mocha Test. CRT, tACS, and CRT + tACS interventions were held twice a week for 12 sessions each. Each session of CRT and tACS lasted 20 minutes, and each session of cognitive rehabilitation treatment plus TACS was performed for 40 minutes, and the group receiving vitamin D; received 20 micrograms equivalent to 800 IU of vitamin D daily for six weeks. Before conducting the research, the Beck depression test (BDI) and MoCA test were taken, and at the end of the research, BDI was taken to check the effectiveness of treatments on reducing depression. To analyze the results, the repeated measurement statistical test with a significance level of less than 0.05 was used. Findings: The results showed that the depression scores decreased significantly in the cognitive rehabilitation intervention group from 11 to 9. However, no significant difference was observed in the transcranial alternating current stimulation (tACS) and combination of CRT and tACS and vitamin D groups. Conclusion: According to the present study, CRT decreased depression scores in MCI, and it is more effective in reducing depression compared to tACS, CRT+tACS, and vitamin D.

https://jims.mui.ac.ir/article_31130_319b4401f81f42d06aec44e1fd6edd9a.pdf