Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 42 762 2024 05 21 Comparison of the Effect of Running and Swimming on Some Liver Enzymes of Male Rats Induced by Doxorubicin Comparison of the Effect of Running and Swimming on Some Liver Enzymes of Male Rats Induced by Doxorubicin 248 255 31228 10.48305/jims.v42.i762.0248 FA Gholamhasan Jafarzadeh Faculty Member of Behbahan Khatam Alanbia University of Technology, Behbahan, Iran 0000-0002-6060-5808 Azadeh Zamani Behbahani Behbahan Faculty of Medical Science, Behbahan, Iran 0009-0008-4575-1816 Mehdi Yaghmaei Behbahan Khatam Alanbia University of Technology, Behabahan, Iran Mohammad Salehi Veisi Department of Statistics, Faculty of Data and Energy Sciences Behbahan Khatam Alanbia University of Technology, Behabahan, Iran 0000-0002-2065-9553 Journal Article 2024 07 03 Background: Various exercises have been studied to reduce the complications caused by the use of doxorubicin and other chemotherapy drugs on healthy body organs; But a limited number of these studies have compared the effect of different sports programs; Therefore, the aim of this study is to compare running and swimming on some liver enzymes of rats induced by doxorubicin. Methods: 36 adult male desert mice weighing 230 to 280 grams were randomly divided into 6 groups of 6: resting sham (SH), treadmill sham (SHT), swimming sham (SHS), doxorubicin rest (D), doxorubicin treadmill (DT), doxorubicin swimming (DS) were divided. The sports groups did the exercise program 5 sessions a week for 6 weeks. 24 hours after the last exercise session, blood was taken from the left ventricle of the animal with a syringe. To analyze the data, descriptive analysis and one-way analysis of variance, ANOVA and Tukey's post hoc test at a significance level of 0.05. Findings: Doxorubicin injection caused a significant increase in ALP, SGPT, and SGOT enzymes, both running and swimming exercises caused a significant decrease in ALP, SGPT, and SGOT enzymes, but there was no significant difference between the running and swimming groups on the reduction of the studied enzymes. Conclusion: Based on the results of the present study, it seems that endurance sports activities are a good way to reduce hepatotoxicity caused by doxorubicin injection in cancer patients, and none of the swimming and running exercises are preferable to the other. Background: Various exercises have been studied to reduce the complications caused by the use of doxorubicin and other chemotherapy drugs on healthy body organs; But a limited number of these studies have compared the effect of different sports programs; Therefore, the aim of this study is to compare running and swimming on some liver enzymes of rats induced by doxorubicin. Methods: 36 adult male desert mice weighing 230 to 280 grams were randomly divided into 6 groups of 6: resting sham (SH), treadmill sham (SHT), swimming sham (SHS), doxorubicin rest (D), doxorubicin treadmill (DT), doxorubicin swimming (DS) were divided. The sports groups did the exercise program 5 sessions a week for 6 weeks. 24 hours after the last exercise session, blood was taken from the left ventricle of the animal with a syringe. To analyze the data, descriptive analysis and one-way analysis of variance, ANOVA and Tukey's post hoc test at a significance level of 0.05. Findings: Doxorubicin injection caused a significant increase in ALP, SGPT, and SGOT enzymes, both running and swimming exercises caused a significant decrease in ALP, SGPT, and SGOT enzymes, but there was no significant difference between the running and swimming groups on the reduction of the studied enzymes. Conclusion: Based on the results of the present study, it seems that endurance sports activities are a good way to reduce hepatotoxicity caused by doxorubicin injection in cancer patients, and none of the swimming and running exercises are preferable to the other.

https://jims.mui.ac.ir/article_31228_e5654b80531b9a7338900193f90fbba5.pdf