Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 42 764 2024 05 21 Effect of Continuous and Intermittent Aerobic Training on Serum Galectin3 and Insulin Resistance in Wistar Rats with Gestational Diabetes Mellitus Effect of Continuous and Intermittent Aerobic Training on Serum Galectin3 and Insulin Resistance in Wistar Rats with Gestational Diabetes Mellitus 317 324 31232 10.48305/jims.v42.i764.0317 FA Ahmad Arbabi PhD Student of Exercise Physiology, Department of Sport Sciences, University of Birjand, Iran 0009-0005-0303-1405 Mehdi Mogharnasi Professor of Exercise Physiology, Department of Sport Sciences, University of Birjand, Iran 0000-0002-9351-5948 Hamed Fanaei Associate Professor, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran 0000-0002-1345-2052 Javad Nakhzari Khodakheir Assistant Professor, Department of Physical Education and Sport Sciences, School of Human Sciences, University of Zabol, Zabol, Iran 0000-0002-9628-2676 Journal Article 2024 06 22 <strong>Background:</strong><em> </em>Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. This study aims to present the potential and significance of Galectin3 (GAL3) in the pathogenesis of GDM. <strong>Methods:</strong><strong> </strong>Sixty female Wistar rats (weighting 220 ± 10g) were randomly assigned into six groups: control (Ctr) group, control+continuous aerobic training (Ctr+CON) group, control+intermittent aerobic training (Ctr+INT) group, gestational diabetes mellitus (GDM) group, GDM+continuous aerobic training (GDM+CON) group, GDM+intermittent aerobic training (GDM+INT) group. Exercise groups underwent treadmill exercise during pregnancy. Levels of insulin resistance and galectin3 were measured. <strong>Findings:</strong><strong> </strong>Serum galectin3 concentration in the GDM group was significantly higher than Ctr. On the other hand, the galectin3 level in the GDM+CON and GDM+INT groups was considerably lower than in the GDM group. The weight of the GDM group was significantly higher than the Ctr and training groups on the 20^th day of gestation. Insulin resistance levels in the GDM+CON and GDM+INT groups were significantly lower than in the GDM group. <strong>Conclusion:</strong> The study results demonstrate that both continuous and intermittent training effectively improved GDM. However, there was no statistically significant difference between the two training models. In addition, a significant positive correlation was found between galectin3 and GDM. It may be used as a potential factor to predict the development of GDM. <strong>Background:</strong><em> </em>Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. This study aims to present the potential and significance of Galectin3 (GAL3) in the pathogenesis of GDM. <strong>Methods:</strong><strong> </strong>Sixty female Wistar rats (weighting 220 ± 10g) were randomly assigned into six groups: control (Ctr) group, control+continuous aerobic training (Ctr+CON) group, control+intermittent aerobic training (Ctr+INT) group, gestational diabetes mellitus (GDM) group, GDM+continuous aerobic training (GDM+CON) group, GDM+intermittent aerobic training (GDM+INT) group. Exercise groups underwent treadmill exercise during pregnancy. Levels of insulin resistance and galectin3 were measured. <strong>Findings:</strong><strong> </strong>Serum galectin3 concentration in the GDM group was significantly higher than Ctr. On the other hand, the galectin3 level in the GDM+CON and GDM+INT groups was considerably lower than in the GDM group. The weight of the GDM group was significantly higher than the Ctr and training groups on the 20^th day of gestation. Insulin resistance levels in the GDM+CON and GDM+INT groups were significantly lower than in the GDM group. <strong>Conclusion:</strong> The study results demonstrate that both continuous and intermittent training effectively improved GDM. However, there was no statistically significant difference between the two training models. In addition, a significant positive correlation was found between galectin3 and GDM. It may be used as a potential factor to predict the development of GDM. https://jims.mui.ac.ir/article_31232_2d1838bd5b731e64a54439dac82b3a4e.pdf