Isfahan University of Medical SciencesJournal of Isfahan Medical School1027-75954069414011011The Effect of 10 Weeks Combined Training in Water on Immunosenescence
in Elderly RatsThe Effect of 10 Weeks Combined Training in Water on Immunosenescence
in Elderly Rats8908992626710.48305/jims.v40.i694.0890FAMohammadJahanmahinPhD Student of Hakim Sabzevari University, School of Physical Education & Sport Sciences, Department of Exercise Physiology, Sabzevar, Iran0000-0001-8682-9175RoyaAskariAssociate Professor of Exercise Physiology, Department of Exercise Physiology, School of Physical Education & Sport Sciences, University of Hakim Sabzevari, Sabzevar, Iran0000-0003-4331-2293AmirhoseinHaghighiProfessor of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education & Sport Sciences, University of Hakim Sabzevari, Sabzevar, IranTaktomHajjarAssistant Professor of Hakim Sabzevari University, Department of Basic Sciences, School of Biology, Sabzevar, Iran0000-0003-1574-999XJournal Article<strong>Background:</strong><em> </em>A complex of restricted naïve lymphocytes in conjunction with an age-associated accumulation of senescent T cells and/or thymic involution are major contributors to immunosenescence, which can be modulated by exercise training. Therefore, the present study aims to investigate 10 weeks of combined training in water on immunosenescence<strong> </strong>in elderly rats.<br /><strong>Methods:</strong><strong> </strong>16 rats for 24 months with mean weight 320 ± 5gr were randomly distributed into a control group <br />(n = 8) and combined training (n = 8). Combined training was performed in 4 sessions per week (two endurance days and two resistance days) in a container with dimensions of 50×50×100 centimeter with water at 30 ± 1 <sup>º</sup>C. Data were analyzed by one-way ANOVA test.<br /><strong>Findings:</strong><strong> </strong>A significant decrease was observed in training groups than control in thymus weight and indicators related to senescent TCD8+<em> </em>and senescent naïve TCD8+ and TCD4+ (P = 0.01), as well as, there was a significant increase in indicators related to CD4+ and CD8+ and naïve TCD8+ and TCD4+ lymphocytes <br />(P = 0.01). While wasn't observed significant difference between CD4+/CD8+ ratio and indicators related to senescent TCD4+ (P = 0.48 and P = 0.19, respectively).<br /><strong>Conclusion:</strong> The results of this study suggest that combined training in water is a safe activity for the elderly to improve the immune system and reduction of senescence-prone T cells.<strong>Background:</strong><em> </em>A complex of restricted naïve lymphocytes in conjunction with an age-associated accumulation of senescent T cells and/or thymic involution are major contributors to immunosenescence, which can be modulated by exercise training. Therefore, the present study aims to investigate 10 weeks of combined training in water on immunosenescence<strong> </strong>in elderly rats.<br /><strong>Methods:</strong><strong> </strong>16 rats for 24 months with mean weight 320 ± 5gr were randomly distributed into a control group <br />(n = 8) and combined training (n = 8). Combined training was performed in 4 sessions per week (two endurance days and two resistance days) in a container with dimensions of 50×50×100 centimeter with water at 30 ± 1 <sup>º</sup>C. Data were analyzed by one-way ANOVA test.<br /><strong>Findings:</strong><strong> </strong>A significant decrease was observed in training groups than control in thymus weight and indicators related to senescent TCD8+<em> </em>and senescent naïve TCD8+ and TCD4+ (P = 0.01), as well as, there was a significant increase in indicators related to CD4+ and CD8+ and naïve TCD8+ and TCD4+ lymphocytes <br />(P = 0.01). While wasn't observed significant difference between CD4+/CD8+ ratio and indicators related to senescent TCD4+ (P = 0.48 and P = 0.19, respectively).<br /><strong>Conclusion:</strong> The results of this study suggest that combined training in water is a safe activity for the elderly to improve the immune system and reduction of senescence-prone T cells.https://jims.mui.ac.ir/article_26267_ace2ee44526353c15f2122bf0f053b73.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75954069414011011The Effect of Golghand (Rosadamacena) on Cognitive Status of Elderly with Mild Cognitive ImpairmentThe Effect of Golghand (Rosadamacena) on Cognitive Status of Elderly with Mild Cognitive Impairment9009072628010.48305/jims.v40.i694.0900FAFatemehKameliInstructor of Community Health Nursing, School of Nursing, Gonabad University of Medical Sciences, Gonabad, Iran0000-0002-6543-5932HossianMohammadzadeh MoghaddamAssistant Professor of Traditional Medicine, School of Medicine, Social Development and Health Promotion Research Centre, Gonabad University of Medical Sciences, Gonabad, IranMahdiBasiri MoghadamDepartment of Medical-Surgical Nursing, School of Nursing, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran0000-0001-5689-2253LeilaSadegh MoghadamAssistant Professor of Gerontology Department of Gerontology, School of Nursing, Gonabad University of Medical Sciences, Gonabad, Iran0000-0003-1808-7039AliDelshad NoghabiInstructor of Community Health Nursing, School of Nursing, Gonabad University of Medical Sciences, Gonabad, Iran0000-0001-9844-7967Journal Article<strong>Background:</strong><em> </em>Cognitive disorders are one of the most important disorders occurring among the elderly. The present study was designed to evaluate the effect of Golghand consumption on the cognitive status of the elderly people with mild cognitive impairment.<br /><strong>Methods:</strong><strong> </strong>In this randomized clinical trial study, 70 elderly people aged 60-75 years after completing the demographic, elderly depression and brief cognitive status questionnaires in several stages and random allocation were divided into two groups of intervention and control. The intervention group used Golgand potion once a day for one month. At the end of the post-test questionnaire was completed for both groups. The data were analyzed with independent t and paired t statistical tests with significance level of less than 0.05.<br /><strong>Findings:</strong><strong> </strong>The mean and standard deviation of the cognitive status score in the experimental group before and after the intervention was 22.57 and 26.17, respectively. The same in score in the control group was 22.65 and 22.66, respectively. The cognitive status scores increased significantly in the intervention group. (P = 0.027), but no significant difference was observed in the control group (P = 0.865). The results also showed a significant increase in the cognitive status scores in the dimensions of orientation, attention, calculation and recall of the questionnaire in the experimental group in the posttest phase (P < 0.05).<br /><strong>Conclusion:</strong> According to the present study, Golghand increased cognitive status scores in the intervention group, which indicates the improvement of mild cognitive impairment in the elderly people and the prevention of Alzheimer's diseases.<strong>Background:</strong><em> </em>Cognitive disorders are one of the most important disorders occurring among the elderly. The present study was designed to evaluate the effect of Golghand consumption on the cognitive status of the elderly people with mild cognitive impairment.<br /><strong>Methods:</strong><strong> </strong>In this randomized clinical trial study, 70 elderly people aged 60-75 years after completing the demographic, elderly depression and brief cognitive status questionnaires in several stages and random allocation were divided into two groups of intervention and control. The intervention group used Golgand potion once a day for one month. At the end of the post-test questionnaire was completed for both groups. The data were analyzed with independent t and paired t statistical tests with significance level of less than 0.05.<br /><strong>Findings:</strong><strong> </strong>The mean and standard deviation of the cognitive status score in the experimental group before and after the intervention was 22.57 and 26.17, respectively. The same in score in the control group was 22.65 and 22.66, respectively. The cognitive status scores increased significantly in the intervention group. (P = 0.027), but no significant difference was observed in the control group (P = 0.865). The results also showed a significant increase in the cognitive status scores in the dimensions of orientation, attention, calculation and recall of the questionnaire in the experimental group in the posttest phase (P < 0.05).<br /><strong>Conclusion:</strong> According to the present study, Golghand increased cognitive status scores in the intervention group, which indicates the improvement of mild cognitive impairment in the elderly people and the prevention of Alzheimer's diseases.https://jims.mui.ac.ir/article_26280_fd068634f56443e7ef424870db309a61.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75954069420230101The Effect of 12 Weeks of Concurrent Training (Aerobic and Strength) on the Levels of miR-155 and C-reactive Protein in Obese Middle-Aged MenThe Effect of 12 Weeks of Concurrent Training (Aerobic and Strength) on the Levels of miR-155 and C-reactive Protein in Obese Middle-Aged Men9089162629010.48305/jims.v40.i694.0908FAAmirShakibPhD Student in Exercise Physiology, School of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran0000-0002-5886-988XRaminAmirsasanAssociate Professor, Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tabriz, Tabriz ,Iran0000-0002-0329-6973VahidSari-SarrafAssociate Professor, Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tabriz, Tabriz ,Iran0000-0001-8452-7966JavadVakiliAssociate Professor, Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tabriz, Tabriz ,Iran0000-0002-1479-0651Journal Article<strong>Background:</strong><em> </em>Some micro RNAs (miRNA) are secreted by adipose tissue and play a role in intercellular communication and are considered as a valuable target point in order to control obesity and its consequences. The aim of the present study is to determine the effect of two concurrent aerobic and strength training methods on the levels of miR-155 and C-reactive protein (CRP) in obese middle-aged men.
<strong>Methods:</strong><strong> </strong>Thirty middle-aged men with an average age of 44.57 ± 3.54 years and weight 103.79 ± 8.46 kg, randomly and based on fat percentage, aerobic capacity (V̇O<sub>2</sub>max) and one repetition maximum (1-RM) were assigned to three groups: 1) concurrent aerobic and strength training in one day (CAST1), 2) concurrent aerobic and strength training on separate days (CAST2) and 3) control group. Blood samples were collected from the subjects 48 hours before and after 12 weeks of concurrent training, in order to analyse of miR-155, CRP and glucose indices. One-way ANOVA with repeated measures and Bonferroni's post hoc test were used to analyze the data.
<strong>Findings:</strong><strong> </strong>After 12 weeks of training, CAST1 group experienced a significant decrease in miR-155, CRP and glucose indices compared to the control group. Also, in the CAST2 group, miR-155, CRP and glucose indices were significantly decreased compared to the control group.
<strong>Conclusion:</strong> It seems that both CAST training methods reduce obesity-related inflammation by affecting <br />miR-155, and middle-aged men may be able to use both training methods to prevent metabolic diseases.<strong>Background:</strong><em> </em>Some micro RNAs (miRNA) are secreted by adipose tissue and play a role in intercellular communication and are considered as a valuable target point in order to control obesity and its consequences. The aim of the present study is to determine the effect of two concurrent aerobic and strength training methods on the levels of miR-155 and C-reactive protein (CRP) in obese middle-aged men.
<strong>Methods:</strong><strong> </strong>Thirty middle-aged men with an average age of 44.57 ± 3.54 years and weight 103.79 ± 8.46 kg, randomly and based on fat percentage, aerobic capacity (V̇O<sub>2</sub>max) and one repetition maximum (1-RM) were assigned to three groups: 1) concurrent aerobic and strength training in one day (CAST1), 2) concurrent aerobic and strength training on separate days (CAST2) and 3) control group. Blood samples were collected from the subjects 48 hours before and after 12 weeks of concurrent training, in order to analyse of miR-155, CRP and glucose indices. One-way ANOVA with repeated measures and Bonferroni's post hoc test were used to analyze the data.
<strong>Findings:</strong><strong> </strong>After 12 weeks of training, CAST1 group experienced a significant decrease in miR-155, CRP and glucose indices compared to the control group. Also, in the CAST2 group, miR-155, CRP and glucose indices were significantly decreased compared to the control group.
<strong>Conclusion:</strong> It seems that both CAST training methods reduce obesity-related inflammation by affecting <br />miR-155, and middle-aged men may be able to use both training methods to prevent metabolic diseases.https://jims.mui.ac.ir/article_26290_72dee70a8d52e44dd4e2bd463b806ffe.pdf