Isfahan University of Medical SciencesJournal of Isfahan Medical School1027-75954276420240521Evaluation of the Therapeutic Outcomes of Patients Poisoned with Paraquat Poison Treated with New Treatment Instructions in the Poisoning Department of Khurshid Hospital in Isfahan from 2018 to 2020Evaluation of the Therapeutic Outcomes of Patients Poisoned with Paraquat Poison Treated with New Treatment Instructions in the Poisoning Department of Khurshid Hospital in Isfahan from 2018 to 20202973073123610.48305/jims.v42.i764.0297FAGholamaliDorooshiAssociate Professor, Department of Clinical Toxicology, School of Medicine, Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran0000-0003-2552-0961NavidFereidaniGeneral Practitioner, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-4341-4348Mohammad RasoulZohour SoleimaniGeneral Practitioner, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-1965-291XShafea JafarZoofaghariClinical Toxicology Fellowship, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-8764-2847NastaranEizadi-MoodProfessor, Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-9792-8160Journal Article20220826<strong>Background:</strong><em> </em>Considering the high prevalence of paraquat poisoning with the intention of suicide and its extremely deadly effects on the major organs of the body, choosing the best treatment can play a significant role in reducing the mortality rate of these patients. For this purpose, this study was conducted to evaluate the therapeutic outcomes of paraquat-poisoned patients treated with a new treatment protocol.<br /><strong>Methods:</strong><strong> </strong>The current retrospective study was conducted on 39 paraquat-poisoned patients treated with a new protocol. In the new protocol, in addition to the standard protocol, treatment with curcuma, pirfenidone, selenium plus, and silymarin is prescribed by gavage. By referring to the archive, basic and clinical information of these patients was extracted and recorded.<br /><strong>Findings:</strong><strong> </strong>In this study, 18 (46.2%) recovered and 21 (53.8%) died. The prevalence of mortality was significantly related to the frequency distribution of gender and age of patients. Hence, the percentage of mortality was higher in men and in those over 35 years of age. In addition, in the new treatment protocol, it was found that although the administration of selenium, curcumin, and silymarin increased the chances of patients' recovery to an insignificant extent (P > 0.05), the administration of pirfenidone can significantly increase the recovery of patients (OR = 3.14 and P = 0.028).<br /><strong>Conclusion:</strong> According to the results of the present study, the administration of pirfenidone and other antioxidants can increase the recovery rate. Although the administration of silymarin, selenium, and curcumin did not show a significant relationship in terms of reducing mortality or increasing recovery, it seems that the treatment regimen based on these drugs results in a higher recovery rate.<strong>Background:</strong><em> </em>Considering the high prevalence of paraquat poisoning with the intention of suicide and its extremely deadly effects on the major organs of the body, choosing the best treatment can play a significant role in reducing the mortality rate of these patients. For this purpose, this study was conducted to evaluate the therapeutic outcomes of paraquat-poisoned patients treated with a new treatment protocol.<br /><strong>Methods:</strong><strong> </strong>The current retrospective study was conducted on 39 paraquat-poisoned patients treated with a new protocol. In the new protocol, in addition to the standard protocol, treatment with curcuma, pirfenidone, selenium plus, and silymarin is prescribed by gavage. By referring to the archive, basic and clinical information of these patients was extracted and recorded.<br /><strong>Findings:</strong><strong> </strong>In this study, 18 (46.2%) recovered and 21 (53.8%) died. The prevalence of mortality was significantly related to the frequency distribution of gender and age of patients. Hence, the percentage of mortality was higher in men and in those over 35 years of age. In addition, in the new treatment protocol, it was found that although the administration of selenium, curcumin, and silymarin increased the chances of patients' recovery to an insignificant extent (P > 0.05), the administration of pirfenidone can significantly increase the recovery of patients (OR = 3.14 and P = 0.028).<br /><strong>Conclusion:</strong> According to the results of the present study, the administration of pirfenidone and other antioxidants can increase the recovery rate. Although the administration of silymarin, selenium, and curcumin did not show a significant relationship in terms of reducing mortality or increasing recovery, it seems that the treatment regimen based on these drugs results in a higher recovery rate.https://jims.mui.ac.ir/article_31236_07c3f887cc69caf06f342a367cfe6304.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75954276420240521The Impacts of Online Prenatal Education Classes on the Mental Health Indicators of Pregnant WomenThe Impacts of Online Prenatal Education Classes on the Mental Health Indicators of Pregnant Women3083163122710.48305/jims.v42.i764.0308FAAshrafSaberMSc, Department of Nursing, School of Medical Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran0000-0003-1887-9140Seyedeh MahboobehRezaeeanInstructor, Master of Midwifery, Department. of Midwifery, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, IranRahmanPanahiAssistant Professor, Department of Public Health, Qaen School of Medical Sciences, Birjand University of Medical Sciences, Birjand, IranFereshtehEidyPhD Student of Biostatistics, School of Medical Sciences, Tarbiat Modares University, Tehran, IranZohrehDastbandBS in nursing, Department of Nursing, School of Medical Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran0000-0002-6621-0495AhmadrezaShamsabadiAssistant Professor, PhD in Health Information Management, Department of Health Information Management, School of Medical Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran0000-0001-9336-1590FatemehAkhawanBS in Midwifery, Deputy health, School of Medical Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran0000-0002-3217-3235ElhamNameniBS in Midwifery, Deputy health, School of Medical Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran0000-0001-6824-5344ShivaPouraliroudbanehPhD Student, Psychosocial Health and Wellbeing research (emPoweR) Unit, Department of Obstetrics and Gynaecology, University of Melbourne, Australia0000-0001-8198-0247Journal Article20231231<strong>Background:</strong><em> </em>This study aims to investigate the impacts of online prenatal education classes on the Mental health indicators of pregnant women.
<strong>Methods:</strong><strong> </strong>This is a randomized quasi-experimental intervention study (one-group pretest-post test). Among the pregnant women referring to the health centers of Esfarayen City, 28 women at 16 to 20 weeks gestation with a low-risk pregnancy were selected by multistage cluster sampling. Six sessions of Skyroom software-based online prenatal classes were conducted for these women in the second trimester. The Depression Anxiety and Stress Scale 21 (DASS-21), a self-report scale, was used to measure anxiety, stress, and depression. Participants complete the questionnaire before the intervention and one month after the last session.
<strong>Findings:</strong><strong> </strong>The results showed that the average scores of depression (P < 0.01) and stress (P = 0.02) in pregnant women significantly decreased one month after the Online prenatal education classes. However, no significant change was observed in the average score of anxiety (P > 0.05). There was no significant relationship between demographic and mental health indicators before and after the intervention (P > 0.05).
<strong>Conclusion:</strong> Online prenatal education classes were successful in lowering pregnant women's levels of stress and depression<em>.</em> Although more study needs to concentrate on pregnant women’s mental health by providing a more diverse population, the results from this study clearly show the importance of online support for pregnant women.<strong>Background:</strong><em> </em>This study aims to investigate the impacts of online prenatal education classes on the Mental health indicators of pregnant women.
<strong>Methods:</strong><strong> </strong>This is a randomized quasi-experimental intervention study (one-group pretest-post test). Among the pregnant women referring to the health centers of Esfarayen City, 28 women at 16 to 20 weeks gestation with a low-risk pregnancy were selected by multistage cluster sampling. Six sessions of Skyroom software-based online prenatal classes were conducted for these women in the second trimester. The Depression Anxiety and Stress Scale 21 (DASS-21), a self-report scale, was used to measure anxiety, stress, and depression. Participants complete the questionnaire before the intervention and one month after the last session.
<strong>Findings:</strong><strong> </strong>The results showed that the average scores of depression (P < 0.01) and stress (P = 0.02) in pregnant women significantly decreased one month after the Online prenatal education classes. However, no significant change was observed in the average score of anxiety (P > 0.05). There was no significant relationship between demographic and mental health indicators before and after the intervention (P > 0.05).
<strong>Conclusion:</strong> Online prenatal education classes were successful in lowering pregnant women's levels of stress and depression<em>.</em> Although more study needs to concentrate on pregnant women’s mental health by providing a more diverse population, the results from this study clearly show the importance of online support for pregnant women.https://jims.mui.ac.ir/article_31227_047213fe37bcee03c915839cffd2024b.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75954276420240521Effect of Continuous and Intermittent Aerobic Training on Serum Galectin3 and Insulin Resistance in Wistar Rats with Gestational Diabetes MellitusEffect of Continuous and Intermittent Aerobic Training on Serum Galectin3 and Insulin Resistance in Wistar Rats with Gestational Diabetes Mellitus3173243123210.48305/jims.v42.i764.0317FAAhmadArbabiPhD Student of Exercise Physiology, Department of Sport Sciences, University of Birjand, Iran0009-0005-0303-1405MehdiMogharnasiProfessor of Exercise Physiology, Department of Sport Sciences, University of Birjand, Iran0000-0002-9351-5948HamedFanaeiAssociate Professor, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran0000-0002-1345-2052JavadNakhzari KhodakheirAssistant Professor, Department of Physical Education and Sport Sciences, School of Human Sciences, University of Zabol, Zabol, Iran0000-0002-9628-2676Journal Article20240622<strong>Background:</strong><em> </em>Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. This study aims to present the potential and significance of Galectin3 (GAL3) in the pathogenesis of GDM.
<strong>Methods:</strong><strong> </strong>Sixty female Wistar rats (weighting 220 ± 10g) were randomly assigned into six groups: control (Ctr) group, control+continuous aerobic training (Ctr+CON) group, control+intermittent aerobic training (Ctr+INT) group, gestational diabetes mellitus (GDM) group, GDM+continuous aerobic training (GDM+CON) group, GDM+intermittent aerobic training (GDM+INT) group. Exercise groups underwent treadmill exercise during pregnancy. Levels of insulin resistance and galectin3 were measured.
<strong>Findings:</strong><strong> </strong>Serum galectin3 concentration in the GDM group was significantly higher than Ctr. On the other hand, the galectin3 level in the GDM+CON and GDM+INT groups was considerably lower than in the GDM group. The weight of the GDM group was significantly higher than the Ctr and training groups on the 20<sup>th</sup> day of gestation. Insulin resistance levels in the GDM+CON and GDM+INT groups were significantly lower than in the GDM group.
<strong>Conclusion:</strong> The study results demonstrate that both continuous and intermittent training effectively improved GDM. However, there was no statistically significant difference between the two training models. In addition, a significant positive correlation was found between galectin3 and GDM. It may be used as a potential factor to predict the development of GDM.<strong>Background:</strong><em> </em>Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. This study aims to present the potential and significance of Galectin3 (GAL3) in the pathogenesis of GDM.
<strong>Methods:</strong><strong> </strong>Sixty female Wistar rats (weighting 220 ± 10g) were randomly assigned into six groups: control (Ctr) group, control+continuous aerobic training (Ctr+CON) group, control+intermittent aerobic training (Ctr+INT) group, gestational diabetes mellitus (GDM) group, GDM+continuous aerobic training (GDM+CON) group, GDM+intermittent aerobic training (GDM+INT) group. Exercise groups underwent treadmill exercise during pregnancy. Levels of insulin resistance and galectin3 were measured.
<strong>Findings:</strong><strong> </strong>Serum galectin3 concentration in the GDM group was significantly higher than Ctr. On the other hand, the galectin3 level in the GDM+CON and GDM+INT groups was considerably lower than in the GDM group. The weight of the GDM group was significantly higher than the Ctr and training groups on the 20<sup>th</sup> day of gestation. Insulin resistance levels in the GDM+CON and GDM+INT groups were significantly lower than in the GDM group.
<strong>Conclusion:</strong> The study results demonstrate that both continuous and intermittent training effectively improved GDM. However, there was no statistically significant difference between the two training models. In addition, a significant positive correlation was found between galectin3 and GDM. It may be used as a potential factor to predict the development of GDM.https://jims.mui.ac.ir/article_31232_2d1838bd5b731e64a54439dac82b3a4e.pdf