Isfahan University of Medical SciencesJournal of Isfahan Medical School1027-75954278620241121A Comparative Study of Oral and Pharyngeal Adverse Events in Breast Cancer Patients Undergoing Conventional and Hypofractionated RadiotherapyA Comparative Study of Oral and Pharyngeal Adverse Events in Breast Cancer Patients Undergoing Conventional and Hypofractionated Radiotherapy8698753132810.48305/jims.v42.i786.0869FAKoroshSaberPhD, Department of Medical Physics, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran0000-0003-1934-7699SiminHematiAssociate Professor, Department of Radiation Oncology, School of Medicine, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-7517-8987Mohammad MehdiAzizi Bondarabadi3 -MSc Medical Imaging Technology Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran0009-0004-0875-9465SepidehTorabiBachelor of Radiation Therapy, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, IranAhmadShaneiPhD in Medical Physics, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-5999-0932Journal Article20240812<strong>Background:</strong><em> </em>Radiation therapy is one of the primary treatment methods for breast cancer. Oral and pharyngeal complications are significant challenges associated with this treatment. This study aimed to compare the oral and pharyngeal complications in patients receiving radiation therapy using two techniques: conventional and hypofractionated.<br /><strong>Methods:</strong><strong> </strong>In this cross-sectional analytical study, 70 breast cancer patients treated at Seyed-al-Shohada Hospital in Isfahan in 2024 were examined. The patients were divided into two groups: those receiving conventional radiation therapy (5000 cGy in 25 fractions) and those undergoing hypofractionated radiation therapy (4250 cGy in 16 fractions). Oral and pharyngeal complications were assessed and compared during treatment and up to 60 days post-treatment based on the CTCAE V5 criteria in both groups.<br /><strong>Findings:</strong><strong> </strong>The findings of this study demonstrated a significantly higher incidence of acute oral and pharyngeal adverse events in the conventional radiotherapy group compared to the hypofractionated radiotherapy group <br />(P = 0.05). Specifically, the prevalence of moderate (grade 2) and severe (grade 3) adverse events was 17.1% and 8.5% in the conventional group, respectively, compared to 14.2% and 0% in the hypofractionated group. Data analysis indicated that the clinical variables of age, body mass index (BMI), and concurrent chemotherapy also had a significant impact on the severity of oral and pharyngeal adverse events in both treatment groups (P < 0.05).<br /><strong>Conclusion:</strong> This clinical study demonstrated that patients receiving hypofractionated radiation therapy experienced fewer oral and pharyngeal complications than those treated with the conventional technique.<strong>Background:</strong><em> </em>Radiation therapy is one of the primary treatment methods for breast cancer. Oral and pharyngeal complications are significant challenges associated with this treatment. This study aimed to compare the oral and pharyngeal complications in patients receiving radiation therapy using two techniques: conventional and hypofractionated.<br /><strong>Methods:</strong><strong> </strong>In this cross-sectional analytical study, 70 breast cancer patients treated at Seyed-al-Shohada Hospital in Isfahan in 2024 were examined. The patients were divided into two groups: those receiving conventional radiation therapy (5000 cGy in 25 fractions) and those undergoing hypofractionated radiation therapy (4250 cGy in 16 fractions). Oral and pharyngeal complications were assessed and compared during treatment and up to 60 days post-treatment based on the CTCAE V5 criteria in both groups.<br /><strong>Findings:</strong><strong> </strong>The findings of this study demonstrated a significantly higher incidence of acute oral and pharyngeal adverse events in the conventional radiotherapy group compared to the hypofractionated radiotherapy group <br />(P = 0.05). Specifically, the prevalence of moderate (grade 2) and severe (grade 3) adverse events was 17.1% and 8.5% in the conventional group, respectively, compared to 14.2% and 0% in the hypofractionated group. Data analysis indicated that the clinical variables of age, body mass index (BMI), and concurrent chemotherapy also had a significant impact on the severity of oral and pharyngeal adverse events in both treatment groups (P < 0.05).<br /><strong>Conclusion:</strong> This clinical study demonstrated that patients receiving hypofractionated radiation therapy experienced fewer oral and pharyngeal complications than those treated with the conventional technique.https://jims.mui.ac.ir/article_31328_e82be97d50fa31e032f4789c6685ef05.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75954278620241121Blood Lead Levels in Patients with Age-Related Macular Degeneration: A Case-Control StudyBlood Lead Levels in Patients with Age-Related Macular Degeneration: A Case-Control Study8768833128710.48305/jims.v42.i786.0876FAMinaPuladvandIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran0000-0003-2136-085XMostafaFeghhiDepartment of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0002-5644-5143MohammadMalekahmadiIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran0000-0003-3814-8863FerydounFarrahiDepartment of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0002-1604-1240ZahraRamezaniDepartment of Medicinal Chemistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0001-9531-2952AliShahsavariIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-9531-2952PardisTavallaeinejadIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran0009-0007-9968-9758Journal Article20240827<strong>Background:</strong><em> </em>This study aimed to evaluate blood lead levels in patients with age-related macular degeneration (AMD).<br /><strong>Methods:</strong><strong> </strong>This case-control study was conducted on patients with AMD and healthy controls at Ahvaz, Khozestan, Iran. The control group was randomly selected from the general outpatient clinic. Two groups were matched for the following parameters: age, sex, smoking, lipid profiles, past vascular diseases, and history of ophthalmic surgery.<br /><strong>Findings:</strong><strong> </strong>Ninety-five AMD patients (55.8% male, mean age 69.93 ± 10.17 years) and 95 controls (31.6% male, mean age 65.50 ± 7.65 years) were enrolled. The mean blood lead level in the case and control groups was<br /> 25.70 ± 10.08 and 24.25 ± 9.74 µg/dL, respectively (P = 0.46). Also, after adjusting for confounding factors, there was no significant difference between the two groups' blood lead levels (P = 0.4).<br /><strong>Conclusion:</strong> No significant differences were found in the blood lead levels, indicative of short-term exposure, between patients with AMD and the control group.<strong>Background:</strong><em> </em>This study aimed to evaluate blood lead levels in patients with age-related macular degeneration (AMD).<br /><strong>Methods:</strong><strong> </strong>This case-control study was conducted on patients with AMD and healthy controls at Ahvaz, Khozestan, Iran. The control group was randomly selected from the general outpatient clinic. Two groups were matched for the following parameters: age, sex, smoking, lipid profiles, past vascular diseases, and history of ophthalmic surgery.<br /><strong>Findings:</strong><strong> </strong>Ninety-five AMD patients (55.8% male, mean age 69.93 ± 10.17 years) and 95 controls (31.6% male, mean age 65.50 ± 7.65 years) were enrolled. The mean blood lead level in the case and control groups was<br /> 25.70 ± 10.08 and 24.25 ± 9.74 µg/dL, respectively (P = 0.46). Also, after adjusting for confounding factors, there was no significant difference between the two groups' blood lead levels (P = 0.4).<br /><strong>Conclusion:</strong> No significant differences were found in the blood lead levels, indicative of short-term exposure, between patients with AMD and the control group.https://jims.mui.ac.ir/article_31287_0982d54d18a026163f76888c0d226166.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75954278620241121Examining the Contents of Sorche Substance (God Tear) of Abuse and Products Used in Addiction Treatment and Bodybuilding Drugs Available in Isfahan City Market in Terms of Toxicology ClassificationExamining the Contents of Sorche Substance (God Tear) of Abuse and Products Used in Addiction Treatment and Bodybuilding Drugs Available in Isfahan City Market in Terms of Toxicology Classification8848913132410.48305/jims.v42.i786.0884FAArmanOtroshiAssistant Professor, Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-7185-4562MahsaFarhadianMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran0009-0000-7125-9958HasanBadibostanAssistant Professor, Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran0000-0003-0512-9367NastaranEizadi-MoodProfessor, Clinical Toxicology Department, Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-9792-8160Journal Article20231227<strong>Background:</strong> Due to the entry of various bodybuilding and narcotic compounds into the consumption market and the lack of accurate knowledge of their contents, this study aims to determine the contents of the substance of abuse Sorcheh and the products used in addiction treatment and bodybuilding drugs available in the market of Isfahan city in terms of classification. Toxicology was performed.
<strong>Methods:</strong><strong> </strong>In this cross-sectional study, samples of 7 commercial drugs GC, black raspberry, and Mohazal for obesity treatment and Fereshteh, Galaxy, and Gainup brands for slimming treatment and a narcotic compound called Sorche were examined. Their contents were identified by performing keratography tests and compared with the commercial stickers on their packaging.
<strong>Findings:</strong><strong> </strong>Sibutramine, Morphine, and Fluspirlene are the main ingredients in GC slimming, as Pseudoephedrine, Methamphetamine, and Morphine in black raspberry, Carbamazepine, Morphine, Haloperidol, and Diphenoxylate in Gainup, Morphine, Cyproheptadine, Hydroxyprogesterone, Glutamine, Thioridazine, Chlordiazepoxide, Haloperidol, Epitestrone, Methadone and Betamethasone, in Galoxymelatonin, Clonazepam, Haloperidol, Meperidine, Trifluperidol, and Cyproheptadine, in angel, Haloperidol, Cambinol, Oxazepam, Hydrocortisone, Carbamazepine, Diclofenac, Hydrocortisone, and Imipramine were present. The sample of Sorcheh contained 70% Heroin plus caffeine.
<strong>Conclusion:</strong> Medicines that are sold under the claim of herbal medicines for weight loss and obesity treatment have various chemical compounds, including narcotics and sedatives, which can lead to numerous liver and kidney and may lead to digestive complications in the long run, in addition to drug dependence, cardiac, neurological, and psychological.<strong>Background:</strong> Due to the entry of various bodybuilding and narcotic compounds into the consumption market and the lack of accurate knowledge of their contents, this study aims to determine the contents of the substance of abuse Sorcheh and the products used in addiction treatment and bodybuilding drugs available in the market of Isfahan city in terms of classification. Toxicology was performed.
<strong>Methods:</strong><strong> </strong>In this cross-sectional study, samples of 7 commercial drugs GC, black raspberry, and Mohazal for obesity treatment and Fereshteh, Galaxy, and Gainup brands for slimming treatment and a narcotic compound called Sorche were examined. Their contents were identified by performing keratography tests and compared with the commercial stickers on their packaging.
<strong>Findings:</strong><strong> </strong>Sibutramine, Morphine, and Fluspirlene are the main ingredients in GC slimming, as Pseudoephedrine, Methamphetamine, and Morphine in black raspberry, Carbamazepine, Morphine, Haloperidol, and Diphenoxylate in Gainup, Morphine, Cyproheptadine, Hydroxyprogesterone, Glutamine, Thioridazine, Chlordiazepoxide, Haloperidol, Epitestrone, Methadone and Betamethasone, in Galoxymelatonin, Clonazepam, Haloperidol, Meperidine, Trifluperidol, and Cyproheptadine, in angel, Haloperidol, Cambinol, Oxazepam, Hydrocortisone, Carbamazepine, Diclofenac, Hydrocortisone, and Imipramine were present. The sample of Sorcheh contained 70% Heroin plus caffeine.
<strong>Conclusion:</strong> Medicines that are sold under the claim of herbal medicines for weight loss and obesity treatment have various chemical compounds, including narcotics and sedatives, which can lead to numerous liver and kidney and may lead to digestive complications in the long run, in addition to drug dependence, cardiac, neurological, and psychological.https://jims.mui.ac.ir/article_31324_5b347a27844fa303dd8c02b7da1c9206.pdf