Isfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Evaluation between Fat Distribution in Abdominal CT Scan with Some Physical and Biochemical Variable in Ischemic Patients: GAAMI StudyEvaluation between Fat Distribution in Abdominal CT Scan with Some Physical and Biochemical Variable in Ischemic Patients: GAAMI Study1943195213339FAMasoumeh SadeghiAssociate Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.Hamid SaneiAssociate Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Irana:2:{s:5:"en_US";s:0:"";s:5:"fa_IR";s:0:"";}Ali HekmatniaAssistant Professor, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Babak TavakoliResident, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Maryam BoshtamLaboratory of Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.Mohammad KharkDepartment of Internal Medicine, Emam Hospital, Tehran University of Medical Sciences, Tehran, Iran.Nizal SarrafzadeganProfessor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.0000-0001-9312-6101Journal Article20110319Background: This study aimed to evaluate the relation between fat distribution in subcutaneous and visceral area with other variables in patients suffered for stable angina.Methods: This cross sectional study was done on 40-60 years patients with stable angina. CT scan was determined subcutaneous (deep and superficial) and visceral fat. Body mass index, waist circumference, and blood pressure measurement were calculated by standard protocols. Sugar, triglyceride, total cholesterol, LDL-c, HDL-c, Leptin and apolipoproteins A and B were recorded. Data was entered in SPSS15 and analyzed by Student-t and correlation test.Finding: Sixty-six men and 88 women were studied. The mean of BMI, apo A, Leptin, lipids variables were significantly different in two sexes. Total variable fat accumulation in women was greater than men (P < 0.05). The correlation was significant between weight, BMI, WC and Leptin level in both sexes.Conclusion: Relation of fat distributions and other risk factors was different in both sexes, but BMI and WC had significant correlation with CT scan variables. Background: This study aimed to evaluate the relation between fat distribution in subcutaneous and visceral area with other variables in patients suffered for stable angina.Methods: This cross sectional study was done on 40-60 years patients with stable angina. CT scan was determined subcutaneous (deep and superficial) and visceral fat. Body mass index, waist circumference, and blood pressure measurement were calculated by standard protocols. Sugar, triglyceride, total cholesterol, LDL-c, HDL-c, Leptin and apolipoproteins A and B were recorded. Data was entered in SPSS15 and analyzed by Student-t and correlation test.Finding: Sixty-six men and 88 women were studied. The mean of BMI, apo A, Leptin, lipids variables were significantly different in two sexes. Total variable fat accumulation in women was greater than men (P < 0.05). The correlation was significant between weight, BMI, WC and Leptin level in both sexes.Conclusion: Relation of fat distributions and other risk factors was different in both sexes, but BMI and WC had significant correlation with CT scan variables. https://jims.mui.ac.ir/article_13339_6239a9fbb6f6a2070ec88badac7caea8.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Evaluation of Effects of Acupuncture in Reducing Pain after Wisdom Teeth SurgeryEvaluation of Effects of Acupuncture in Reducing Pain after Wisdom Teeth Surgery1953196013340FANasser KavianiAssistant Professor, Department of Oral & Maxillofacial Surgery, Prof. Torabi Nezhad ReseaAbbas HaghighatAssistant Professor, Department of Oral & Maxillofacial Surgery, Prof. Torabi Nezhad Resea0000-0001-6222-952XSepideh RahmaniDentist, Isfahan, Iran.Journal Article20110319Background: Pain control is important for dentists. NSAID drugs are prevalent and effective analgesic effect, but they have numerous side effects. In this study, an analgesic effect of acupuncture reduces pain and Ibuprofen consumption after surgery was surveyed.Methods: 15 patients that needed two similarly difficult wisdom teeth surgery of both jaws. For study LI4, P6, St7 and St6 acupoints were stimulated by acupuncture needles in one surgery and for placebo acupuncture needles were randomly placed with insufficient depth. After local anesthesia operation was performed. The pain rate, in terms of VAS index, and the numbers of consumed Ibuprofen, at 6, 12, 24 and 48 hours after the surgery were recorded. To do so, we contacted patients by phone and interviewed them.Finding: Regarding the reported post operative pain was lower in study group, but no significant statistical difference was observed. Total amount of consumed Ibuprofen 48 hour after surgery in study group was 2.2 and in placebo group was 3.36 , showed a noticeable decrease in the study group (P = 0.015).Conclusion: Due to an observed reduction in Ibuprofen consumption after the surgery in the study group compared to the placebo group, we conclude that acupuncture is an alternative method in controlling pain for patients with stomach problems.Background: Pain control is important for dentists. NSAID drugs are prevalent and effective analgesic effect, but they have numerous side effects. In this study, an analgesic effect of acupuncture reduces pain and Ibuprofen consumption after surgery was surveyed.Methods: 15 patients that needed two similarly difficult wisdom teeth surgery of both jaws. For study LI4, P6, St7 and St6 acupoints were stimulated by acupuncture needles in one surgery and for placebo acupuncture needles were randomly placed with insufficient depth. After local anesthesia operation was performed. The pain rate, in terms of VAS index, and the numbers of consumed Ibuprofen, at 6, 12, 24 and 48 hours after the surgery were recorded. To do so, we contacted patients by phone and interviewed them.Finding: Regarding the reported post operative pain was lower in study group, but no significant statistical difference was observed. Total amount of consumed Ibuprofen 48 hour after surgery in study group was 2.2 and in placebo group was 3.36 , showed a noticeable decrease in the study group (P = 0.015).Conclusion: Due to an observed reduction in Ibuprofen consumption after the surgery in the study group compared to the placebo group, we conclude that acupuncture is an alternative method in controlling pain for patients with stomach problems.https://jims.mui.ac.ir/article_13340_4df9d129eb5ab7cbf73b26377aec98af.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Prepration of Flexible Plastinated Sheets of Human Brain by P87 PolyesterPrepration of Flexible Plastinated Sheets of Human Brain by P87 Polyester1961196613341FAAbbas Ali RabieiAssistant Professor, Department of Anatomic Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Mohammd Hossein AsadiAssociate Professor, School of Medicine, Baghiatallah University of Medical Sciences, Tehran, Iran.Ebrahim EsfandiariProfessor, Department of Anatomic Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Monir TaghipourMSc Student, School of Medicine, Baghiatallah University of Medical Sciences, Tehran, Iran.Hossein BahadoranAssistant Professor, School of Medicine, Baghiatallah University of Medical Sciences, Tehran, Iran.Mohsen SetayeshChemist, Isfahan University of Medical Sciences, Isfahan, Iran.Atefeh ShamoosiAnatimist, Isfahan University of Medical Sciences, Isfahan, Iran.Mohammad MardaniAssociate Professor, Department of Anatomic Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Bahman RashidiAssistant Professor, Department of Anatomic Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.0000-0003-1133-9571Ataollah FathollahpourAnatimist, Isfahan University of Medical Sciences, Isfahan, Iran.Journal Article20110319Background: Plastination is an excellent technique which helps preserve biological specimens in a dry, odorless, and state. In this technique, water and fat are extracted from tissues and are replaced with curable polyester. Previously prepared plastinated sheets of human brain were fragile and heavy (standard method). The aim of this study was to prepare flexible and light plastinated sheets of human brains.Methods: Two intact human brains were prepared and fixed in 10% formalin for 3 months. After. They were sliced into 3 mm thickness sheets and were dehydrated by acetone in -250C for 4 weeks. Then, the slices were impregnated by P88 flexible polyester in the vacuum chamber. Finally, each slice was cast in an individual flat chamber consisting of 2 standard glass plates by P87 flexible polyester. The transparency, weight, flexibility, bubbling and Gross fragility of the prepared sheets were compared with those of the standard method. The transparency was measured by photometer machine. Their weight was assessed by digital scale; Gross fragility and bubbling were assessed by direct observation. Flexibility of samples was investigated by the degree of bending zero to 45, 45 to 90, 90 to 135 and 135 to 180 degrees of bending were scaled 1, 2, 3 and 4, respectively.Finding: Average light passing, flexible sheets was 85%, while in standard method was 90%. The weights of flexible sheets were 200-400 gr, and in standard method were 600-800 gr. Bubbling and gross fragility were observed in standard method, while no bubbling and gross fragility were observed in flexible sheets. The average flexibility of flexible sheets was, while in standard method was 1.Conclusion: P87 polyester seems to provide lighter and more flexible brain sheets compared with the standard method. Background: Plastination is an excellent technique which helps preserve biological specimens in a dry, odorless, and state. In this technique, water and fat are extracted from tissues and are replaced with curable polyester. Previously prepared plastinated sheets of human brain were fragile and heavy (standard method). The aim of this study was to prepare flexible and light plastinated sheets of human brains.Methods: Two intact human brains were prepared and fixed in 10% formalin for 3 months. After. They were sliced into 3 mm thickness sheets and were dehydrated by acetone in -250C for 4 weeks. Then, the slices were impregnated by P88 flexible polyester in the vacuum chamber. Finally, each slice was cast in an individual flat chamber consisting of 2 standard glass plates by P87 flexible polyester. The transparency, weight, flexibility, bubbling and Gross fragility of the prepared sheets were compared with those of the standard method. The transparency was measured by photometer machine. Their weight was assessed by digital scale; Gross fragility and bubbling were assessed by direct observation. Flexibility of samples was investigated by the degree of bending zero to 45, 45 to 90, 90 to 135 and 135 to 180 degrees of bending were scaled 1, 2, 3 and 4, respectively.Finding: Average light passing, flexible sheets was 85%, while in standard method was 90%. The weights of flexible sheets were 200-400 gr, and in standard method were 600-800 gr. Bubbling and gross fragility were observed in standard method, while no bubbling and gross fragility were observed in flexible sheets. The average flexibility of flexible sheets was, while in standard method was 1.Conclusion: P87 polyester seems to provide lighter and more flexible brain sheets compared with the standard method. https://jims.mui.ac.ir/article_13341_2ca83992dc860744a562322a91b1017f.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Association of Apolipoprotein-A, B and Trans Fatty Acids with Cardiovascular Events: Isfahan Cohort StudyAssociation of Apolipoprotein-A, B and Trans Fatty Acids with Cardiovascular Events: Isfahan Cohort Study1967197713342FANizal SarrafzadeganProfessor, Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.Sedigheh AsgariPharmacognosist, Basic Sciences, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfa-han, Iran.Nafiseh ToghianifarGeneral Practitioner, Quality Control Unit, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.Mohammad TalaeiGeneral Practitioner, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.Aliakbar TavassoliCardiologist, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Maryam BoshtamMSc in Physiology, Laboratory of Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.Masoumeh SadeghiAssociate Professor, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.Journal Article20110319Background: Various studies have shown that the risk of apolipoprotein-A (apo-A), B (apo-B), and trans fatty acids may be different for cardiovascular disease (CVD) events in different populations. This study aimed to estimate the relative risk of apo-A, apo-B, and trans fatty acids for the occurrence of cardiovascular disease events in a cohort study.Methods: A cohort study was performed on 5375 subjects aged ≥ 35 years old participating in the Isfahan Healthy Heart Program (IHHP) that had been recruited with multistage cluster random sampling method. Apo-A and apo-B were measured in all subjects while trans fatty acids were measured on a random sample of 238 subjects. The relative risk of these factors for CVD events was defined in a 6-year period. T-test was used to compare means. Logistic regression and Cox regression were used to calculate Hazard ratio of cardiovascular disease events.Finding: After adjustment for age and sex, the relative risk for cardiovascular disease events was 2.393 (95%CI 1.155-4.961) for apo-B/A, 1.007 (95%CI 1.004-1.009) for total cholesterol, 1.002 (95%CI 1.001-1.003) for triglycerides, and 1.008 (95%CI 1.005-1.010) for LDL-cholesterol. After adjustment for smoking, diabetes, hypertension, and obesity, the relative risk for total cholesterol (1.006, 95%CI 1.003-1.008) and LDL-cholesterol 1.007, 95%CI 1.004-1.010) was significant while insignificant for trans fatty acids.Conclusion: This study showed that relative risk of apo-B/A for cardiovascular disease events is similar to total cholesterol and LDL-cholesterol. However, after adjustment for other risk factors, the association remained significant only for total cholesterol and LDL-cholesterol. Trans fatty acids did not show significant risk for cardiovascular disease event. Background: Various studies have shown that the risk of apolipoprotein-A (apo-A), B (apo-B), and trans fatty acids may be different for cardiovascular disease (CVD) events in different populations. This study aimed to estimate the relative risk of apo-A, apo-B, and trans fatty acids for the occurrence of cardiovascular disease events in a cohort study.Methods: A cohort study was performed on 5375 subjects aged ≥ 35 years old participating in the Isfahan Healthy Heart Program (IHHP) that had been recruited with multistage cluster random sampling method. Apo-A and apo-B were measured in all subjects while trans fatty acids were measured on a random sample of 238 subjects. The relative risk of these factors for CVD events was defined in a 6-year period. T-test was used to compare means. Logistic regression and Cox regression were used to calculate Hazard ratio of cardiovascular disease events.Finding: After adjustment for age and sex, the relative risk for cardiovascular disease events was 2.393 (95%CI 1.155-4.961) for apo-B/A, 1.007 (95%CI 1.004-1.009) for total cholesterol, 1.002 (95%CI 1.001-1.003) for triglycerides, and 1.008 (95%CI 1.005-1.010) for LDL-cholesterol. After adjustment for smoking, diabetes, hypertension, and obesity, the relative risk for total cholesterol (1.006, 95%CI 1.003-1.008) and LDL-cholesterol 1.007, 95%CI 1.004-1.010) was significant while insignificant for trans fatty acids.Conclusion: This study showed that relative risk of apo-B/A for cardiovascular disease events is similar to total cholesterol and LDL-cholesterol. However, after adjustment for other risk factors, the association remained significant only for total cholesterol and LDL-cholesterol. Trans fatty acids did not show significant risk for cardiovascular disease event. https://jims.mui.ac.ir/article_13342_f43e57473e75034e616956ed0ef9d80f.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Comparison the Effect of Intermittent Low Dose Ketamine and Marcaine Infusion through the Sub-pleural Catheter in the Post-Thoracotomy PainComparison the Effect of Intermittent Low Dose Ketamine and Marcaine Infusion through the Sub-pleural Catheter in the Post-Thoracotomy Pain1978198813343FASeyyed Mozafar HashemiAsociate Professor, Deartment of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Seyyed Abass TabatabaieAsociate Professor, Deartment of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Fatemeh NiliMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Golshan TaghipourMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Journal Article20110404Background: Lack of adequate relief of pain after thoracotomy can cause many complications. In this study the effect of using low dose ketamine through sub pleural catheter for pain relief after thoracotomy were compared with marcaine.Methods: In this prospective clinical trial study, patients undergoing elective thoracotomy were included. After thoracotomy, for pain relief the patients in case and control groups received 0.5 mg/kg/hr ketamine and 5 cc marcaine 0.5% through sub pleural catheter, respectively. Vital signs, arterial oxygen saturation, and pain level of patients in both groups were recorded and compared at 1 hour after the surgery in recovery and at 8, 16, and 24 hours after surgeryFindings: In ketamine and marcaine groups, 41 and 51 patients were studied, respectively. Mean pain level before intervention and 8, 16, and 24 hours after it was higher in ketamine group (P < 0.05). One hour after local injection of local anesthetic drugs, the level of pain relief was similar in two studied groups (P > 0.05). Systemic analgesic dose used after thoracotomy was significantly lower in marcaine group than ketamine group (P < 0.05). Mean difference of pain before and after injection of local anesthetic drugs in the two groups did not different significantly (P > 0.05).Conclusion: Low-dose ketamine likewise marcaine could be used as a known local anesthetic for post-operative pain relief but this pain reduction is less due to the short half-life of ketamine. Background: Lack of adequate relief of pain after thoracotomy can cause many complications. In this study the effect of using low dose ketamine through sub pleural catheter for pain relief after thoracotomy were compared with marcaine.Methods: In this prospective clinical trial study, patients undergoing elective thoracotomy were included. After thoracotomy, for pain relief the patients in case and control groups received 0.5 mg/kg/hr ketamine and 5 cc marcaine 0.5% through sub pleural catheter, respectively. Vital signs, arterial oxygen saturation, and pain level of patients in both groups were recorded and compared at 1 hour after the surgery in recovery and at 8, 16, and 24 hours after surgeryFindings: In ketamine and marcaine groups, 41 and 51 patients were studied, respectively. Mean pain level before intervention and 8, 16, and 24 hours after it was higher in ketamine group (P < 0.05). One hour after local injection of local anesthetic drugs, the level of pain relief was similar in two studied groups (P > 0.05). Systemic analgesic dose used after thoracotomy was significantly lower in marcaine group than ketamine group (P < 0.05). Mean difference of pain before and after injection of local anesthetic drugs in the two groups did not different significantly (P > 0.05).Conclusion: Low-dose ketamine likewise marcaine could be used as a known local anesthetic for post-operative pain relief but this pain reduction is less due to the short half-life of ketamine. https://jims.mui.ac.ir/article_13343_ecdb11f0ad44351fb80f01e1151fa3c2.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Asociate Professor, Deartment of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Asociate Professor, Deartment of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.1989199613344FASayyed Morteza HeidariAsociate Professor, Deartment of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.a:2:{s:5:"en_US";s:0:"";s:5:"fa_IR";s:0:"";}Zahra YaraghiMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Journal Article20110404Background: Nausea and vomiting are common post operative complications which prevalence defere due to kind of surgery, kind of anesthesia drug, age, and sex between 20-80%. These complications can make problems such as increasing intracranial pressure, increasing intraoccular pressure, opening operation sutures, aspiration, etc. In some researches, the effect of midazolam in decreasing of vomiting and nausea is proved but there is not any research about the effect of combinating this drug with other drugs. This study aimed to compare the effect of midazolam alone and combination of midazolam and dexamethasone on decreasing postoperative nausea and vomiting.Methods: This clinical trial was done on 2 groups of 33 patient condidated of mastoidectomy at Azahra and Kashani hospitals in Isfahan, Iran. Men and women in ASA classes I and II were divided randomly to 2 groups. Group A recieved 0.075 mg/kg midazolam and group B received 0.075 mg/kg midazolam with 0/05 mg/kg dexamethasone after induction. The severity of nausea by visual analogue scale and number of vomiting were assessed at recovery ward and during 24 hours and were analyzed by t-test.Finding: In recovery ward, the mean score of nausea was 0.88 and 0.48 (P = 0.22) and the mean number of vomiting was 0.09 and 0 (P = 0.039) in groups A anb B, respectively. In first 6 hours, the mean score of nausea was 3.15 and 2.15 (P = 0.14) and the mean number of vomiting was 0.85 and 0.6 (P = 0.26) in groups A anb B, respectively. In second 6 hours, the mean score of nausea was 2.24 and 1.7 (P = 0.3) and the mean number of vomiting was 1.09 and 0.3 (P = 0.04) in groups A anb B, respectively. In second 12 hours, the mean score of nausea was 1.39 and 0.42 (P = 0.049) and the mean number of vomiting was 0.42 and 0.03 P = 0.047) in groups A anb B, respectively. The mean dose of metoclopramid used was 0.51 and 0.51 (P = 0.5) and 12.9 and 6.48 (P = 0.075) at recovery ward and during 24 hours, respectively. The mean time recovery ward hospitalization was 67.8 and 61.3 minutes in groups A anb B, respectively (P = 0.003).Conclusion: Nausea and vomiting in group received midazolam and dexamethasone was less than the group received midazolam alone, particularly in long time.Background: Nausea and vomiting are common post operative complications which prevalence defere due to kind of surgery, kind of anesthesia drug, age, and sex between 20-80%. These complications can make problems such as increasing intracranial pressure, increasing intraoccular pressure, opening operation sutures, aspiration, etc. In some researches, the effect of midazolam in decreasing of vomiting and nausea is proved but there is not any research about the effect of combinating this drug with other drugs. This study aimed to compare the effect of midazolam alone and combination of midazolam and dexamethasone on decreasing postoperative nausea and vomiting.Methods: This clinical trial was done on 2 groups of 33 patient condidated of mastoidectomy at Azahra and Kashani hospitals in Isfahan, Iran. Men and women in ASA classes I and II were divided randomly to 2 groups. Group A recieved 0.075 mg/kg midazolam and group B received 0.075 mg/kg midazolam with 0/05 mg/kg dexamethasone after induction. The severity of nausea by visual analogue scale and number of vomiting were assessed at recovery ward and during 24 hours and were analyzed by t-test.Finding: In recovery ward, the mean score of nausea was 0.88 and 0.48 (P = 0.22) and the mean number of vomiting was 0.09 and 0 (P = 0.039) in groups A anb B, respectively. In first 6 hours, the mean score of nausea was 3.15 and 2.15 (P = 0.14) and the mean number of vomiting was 0.85 and 0.6 (P = 0.26) in groups A anb B, respectively. In second 6 hours, the mean score of nausea was 2.24 and 1.7 (P = 0.3) and the mean number of vomiting was 1.09 and 0.3 (P = 0.04) in groups A anb B, respectively. In second 12 hours, the mean score of nausea was 1.39 and 0.42 (P = 0.049) and the mean number of vomiting was 0.42 and 0.03 P = 0.047) in groups A anb B, respectively. The mean dose of metoclopramid used was 0.51 and 0.51 (P = 0.5) and 12.9 and 6.48 (P = 0.075) at recovery ward and during 24 hours, respectively. The mean time recovery ward hospitalization was 67.8 and 61.3 minutes in groups A anb B, respectively (P = 0.003).Conclusion: Nausea and vomiting in group received midazolam and dexamethasone was less than the group received midazolam alone, particularly in long time.https://jims.mui.ac.ir/article_13344_f30aa03b280b814d1721055f9883292a.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220The Effect of Milk Thistle Extract in the Treatment of Diabetic NephropathyThe Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy1997201013345FAHassan RezvanianAsociate Professor, Deartment of Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAli KachueiAsociate Professor, Deartment of Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAli MirzapourMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Journal Article20110404Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy.Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were analyzed by t and paired-t tests. P < 0.05 was regarded as significant level.Finding: The groups were well matched for age, sex, and duration of diabetes. The mean age was 55.9 ± 6.5 and 57.7 ± 7.7 years in case and control groups, respectively. There was not any significant difference between A/C ratio in case and control groups after intervention (P > 0.05); but in case group, after intervention A/C ratio was worse than before it (P < 0.05).Conclusion: The results suggest that Milk thistle did not improve the renal performance in patients with type II diabetes mellitus. Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy.Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were analyzed by t and paired-t tests. P < 0.05 was regarded as significant level.Finding: The groups were well matched for age, sex, and duration of diabetes. The mean age was 55.9 ± 6.5 and 57.7 ± 7.7 years in case and control groups, respectively. There was not any significant difference between A/C ratio in case and control groups after intervention (P > 0.05); but in case group, after intervention A/C ratio was worse than before it (P < 0.05).Conclusion: The results suggest that Milk thistle did not improve the renal performance in patients with type II diabetes mellitus. https://jims.mui.ac.ir/article_13345_bb88839786efc79b4282b2992d64760d.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Comparison the First and Second Generation Intense Pulsed Light Devices (IPL) Effect on HirsutismComparison the First and Second Generation Intense Pulsed Light Devices (IPL) Effect on Hirsutism2011201513346FAAli AsilianProfessor, Deartment of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.a:2:{s:5:"en_US";s:0:"";s:5:"fa_IR";s:0:"";}Hesam Hassanzade KashaniMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAli MomeniDermatologist Isfahan University of Medical Sciences, Isfahan, Iran.Journal Article20110404Background: Hirsutism is one of the pravalent problems of human and so far many procedures have been suggested to treat it. Intense pulsed light (IPL) considered as one of the procedures with fewer side effects. This study aimed to compare the effect of the first generation of IPL (Lumina) with its second generation (Ellipse) on hirsutism.Methods: In this retrospective study, medical files of the patients who refered to Isfahan Espadana Lasers Center for hair removal were evaluated. Patients were divided into two groups: those treated with Lumina and those treated with Ellipse. The patients’ treatment satisfaction was evaluated during 6 months follow-up period.Finding: Medical files of 235 women were studied; 107 treated with Lumina and 128 with Ellipse. Mean satisfaction of patients in Ellipse and Lumina groups were 78.11 ± 44.49 and 71.13 ± 36.78 respectively (P < 0.05).Conclusion: Hair removal and hirsutism treatment using second generation intense pulsed light (Ellipse) is more effective than the first generation of it (Lumina). Background: Hirsutism is one of the pravalent problems of human and so far many procedures have been suggested to treat it. Intense pulsed light (IPL) considered as one of the procedures with fewer side effects. This study aimed to compare the effect of the first generation of IPL (Lumina) with its second generation (Ellipse) on hirsutism.Methods: In this retrospective study, medical files of the patients who refered to Isfahan Espadana Lasers Center for hair removal were evaluated. Patients were divided into two groups: those treated with Lumina and those treated with Ellipse. The patients’ treatment satisfaction was evaluated during 6 months follow-up period.Finding: Medical files of 235 women were studied; 107 treated with Lumina and 128 with Ellipse. Mean satisfaction of patients in Ellipse and Lumina groups were 78.11 ± 44.49 and 71.13 ± 36.78 respectively (P < 0.05).Conclusion: Hair removal and hirsutism treatment using second generation intense pulsed light (Ellipse) is more effective than the first generation of it (Lumina). https://jims.mui.ac.ir/article_13346_a8ac4113cc2dfa417f67081ae52cfc05.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220The Relation between Serum Levels of Oxidants and Antioxidants with Asthma SeverityThe Relation between Serum Levels of Oxidants and Antioxidants with Asthma Severity2016202213347FATouraj RoshanzamirAsociate Professor, Deartment of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Sahar VahdatResident, Deartment of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Journal Article20110404Background: Asthma considered as an inflammatory disease and the role of systemic and local oxidative stress in the pathogenesis of the disease has been suggested. The imbalance between oxidants and antioxidants has a significant role in the creation and control of asthma symptoms. The aim of this research was to study the relation between serum levels of oxidants and antioxidants with the severity of asthma. Methods: In this observational-analytic cross-sectional study, 59 known asthmatic patients were included. The severity of asthma as mild, moderate, and severe was determined in studied patients based on their medical history, clinical symptoms, and pulmonary function tests. Serum levels of hydrogen superoxide, specific activity of superoxide dismutase enzymes and catalase, and total capacity of antioxidant levels in serum samples were evaluated.Findings: Mild, moderate, and severe asthma was presented among 21 (35.6%), 22 (37.3%), and 16 (27.1%) patients. There was significant positive relationship between the severity of asthma and specific activity of superoxide dismutase (P = 0.04; r = 0.21), mean of serum superoxide hydrogen (P < 0.01; r = 0.23), and the total capacity of antioxidants (P < 0.01; r = 0.31). There was significant negative relationship between the severity of asthma and specific activity of plasma catalase (P = 0.01; r = 0.28).Conclusion: The findings of current study confirmed the role of oxidant/antioxidant balance in asthma severity. To determine the more precise mechanisms of these compounds on pulmonary disease, especially asthma, further interventional studies on the effect of balance modification of oxidant/antioxidant on the severity, control, and the molecular basis of the disease is needed. Background: Asthma considered as an inflammatory disease and the role of systemic and local oxidative stress in the pathogenesis of the disease has been suggested. The imbalance between oxidants and antioxidants has a significant role in the creation and control of asthma symptoms. The aim of this research was to study the relation between serum levels of oxidants and antioxidants with the severity of asthma. Methods: In this observational-analytic cross-sectional study, 59 known asthmatic patients were included. The severity of asthma as mild, moderate, and severe was determined in studied patients based on their medical history, clinical symptoms, and pulmonary function tests. Serum levels of hydrogen superoxide, specific activity of superoxide dismutase enzymes and catalase, and total capacity of antioxidant levels in serum samples were evaluated.Findings: Mild, moderate, and severe asthma was presented among 21 (35.6%), 22 (37.3%), and 16 (27.1%) patients. There was significant positive relationship between the severity of asthma and specific activity of superoxide dismutase (P = 0.04; r = 0.21), mean of serum superoxide hydrogen (P < 0.01; r = 0.23), and the total capacity of antioxidants (P < 0.01; r = 0.31). There was significant negative relationship between the severity of asthma and specific activity of plasma catalase (P = 0.01; r = 0.28).Conclusion: The findings of current study confirmed the role of oxidant/antioxidant balance in asthma severity. To determine the more precise mechanisms of these compounds on pulmonary disease, especially asthma, further interventional studies on the effect of balance modification of oxidant/antioxidant on the severity, control, and the molecular basis of the disease is needed. https://jims.mui.ac.ir/article_13347_ef6631ee9edd8e8b4e9368de71609fd8.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Complication of Abdominolpasty; A Six Years SurveyComplication of Abdominolpasty; A Six Years Survey2023203113348FAMahmood OmranifardAssociate Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-9312-6101Elaheh KheirkhahMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAli Mehrabi KooshkiMSc of Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-5864-4683Journal Article20110404Background: Abdominoplasty is going to be performed in combination with other procedures and it is suggested that such combined procedures may raise the risk of postoperative complications. The purpose of this study was to determine the prevalence of complications in patients underwent abdominoplasty operation.Methods: In a descriptive study, a total of 100 patients who underwent abdominoplasty in hospitals in Isfahan, Iran during 6 years were assessed.Finding: The mean age of petients was 34.3 ± 8.5 years and 77% of them were women. 37% of the patients had one and more complication after the surgery. Wound infection was 2 patients (2%), ischemia in 3, hematoma in 3, seroma in 35, decreased sensation at the site of surgery in 26 and scar in 20 patients were seen. There was not any case of emboli or thromboemboli.Conclusion: According to increasing use of abdominoplasty in recent decades, we encountered too many complications of this kind of surgery. Thus, the patient must be educated about serious complications of this surgery before accepting it. Background: Abdominoplasty is going to be performed in combination with other procedures and it is suggested that such combined procedures may raise the risk of postoperative complications. The purpose of this study was to determine the prevalence of complications in patients underwent abdominoplasty operation.Methods: In a descriptive study, a total of 100 patients who underwent abdominoplasty in hospitals in Isfahan, Iran during 6 years were assessed.Finding: The mean age of petients was 34.3 ± 8.5 years and 77% of them were women. 37% of the patients had one and more complication after the surgery. Wound infection was 2 patients (2%), ischemia in 3, hematoma in 3, seroma in 35, decreased sensation at the site of surgery in 26 and scar in 20 patients were seen. There was not any case of emboli or thromboemboli.Conclusion: According to increasing use of abdominoplasty in recent decades, we encountered too many complications of this kind of surgery. Thus, the patient must be educated about serious complications of this surgery before accepting it. https://jims.mui.ac.ir/article_13348_304da77375299be58a17d6f2222692da.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Comparing the Serum Level of Testosterone and the Relative Frequency of Premature Ejaculation in Patients with Varicocele and Normal PopulationComparing the Serum Level of Testosterone and the Relative Frequency of Premature Ejaculation in Patients with Varicocele and Normal Population2032203813349FAFarhad TadayyonAssistant Professor, Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran .Mehdi MellatResident, Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMohammad Hatef KhorramiAssistant Professor, Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran .Amir Abbas ShahdoostResident, Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranFatemeh Sadat HaghdoostMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20110405Background: Varicocele is defined as elongation and enlargement of of veins leaving the testis which join to form the pampiniform plexusis in the scrotum and can influence the testicular function. Testis is the main source of testosterone that any effect on it can affect this hormone too. Premature ejaculation is defined as to reach orgasm before the desired time or ejaculation before or immediately after sex and is determined by proximity and ejaculation before two minutes after intercourse. This study aimed to investigate the effect of varicocele on serum testosterone levels and premature ejaculation.Methods: In this case-control study, 38 patients with varicocele and 38 healthy individuals, as controls, were selected and their testosterone levels (blood sample before 11 AM), frequency of ejaculation, despite testicular atrophy, and grade of varicocele were assessed and compared.Finding: In patients group 28.9% and in control group 10.5% were suffering from premature ejaculation (P < 0.05). Mean testosterone level was 6.5 ± 1.9 and 7.8 ± 2.1 ng/ml in patients and control groups, respectively. Varicocele grade and testicular atrophy was correlated (05 / 0> P). Despite the testosterone level was lower in patients with varicocele, no significant correlation between testosterone levels and varicocele grade was observed.Conclusion: This study shows a significant relationship between varicocele and premature ejaculation; it seems that in patients with varicocele, testosterone serum level should be measured regularly and And if reduced, to be corrected.Background: Varicocele is defined as elongation and enlargement of of veins leaving the testis which join to form the pampiniform plexusis in the scrotum and can influence the testicular function. Testis is the main source of testosterone that any effect on it can affect this hormone too. Premature ejaculation is defined as to reach orgasm before the desired time or ejaculation before or immediately after sex and is determined by proximity and ejaculation before two minutes after intercourse. This study aimed to investigate the effect of varicocele on serum testosterone levels and premature ejaculation.Methods: In this case-control study, 38 patients with varicocele and 38 healthy individuals, as controls, were selected and their testosterone levels (blood sample before 11 AM), frequency of ejaculation, despite testicular atrophy, and grade of varicocele were assessed and compared.Finding: In patients group 28.9% and in control group 10.5% were suffering from premature ejaculation (P < 0.05). Mean testosterone level was 6.5 ± 1.9 and 7.8 ± 2.1 ng/ml in patients and control groups, respectively. Varicocele grade and testicular atrophy was correlated (05 / 0> P). Despite the testosterone level was lower in patients with varicocele, no significant correlation between testosterone levels and varicocele grade was observed.Conclusion: This study shows a significant relationship between varicocele and premature ejaculation; it seems that in patients with varicocele, testosterone serum level should be measured regularly and And if reduced, to be corrected.https://jims.mui.ac.ir/article_13349_29e1d680456cc4691fe3e06d4f4d1897.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Prognostic Factor and Survival of Patients with Colorectal Cancer after Resection of Pulmonary MetastasePrognostic Factor and Survival of Patients with Colorectal Cancer after Resection of Pulmonary Metastase2039204413350FASeyyed Abass TabatabaieAsociate Professor, Deartment of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranSeyyed Mozafar HashemiAsociate Professor, Deartment of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAmin AhmadMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20110405Background:5-year survival rate of patients undergoing surgical resection of pulmonary metastases from colorectal cancer have been reported variable. Nowadays, there is not a standard guide for selecting patients for lung metastases resection. This study aimed to identify prognostic factors determining overall survival rate of patients after resection of lung metastases in colorectal cancer.Methods: In this cross-sectional study, all the patients underwent resection of lung metastases resulting from colorectal cancer in Alzahra hospital, Isfahan in a ten year period were assessed. Information about age, sex, number of pulmonary metastases, type of metastatectomy, location of surgery, lymph node involvement and its location, size of metastases during surgery, postoperative mortality, survival, history of previous induced liver metastatectomy, pathological findings, and interval of surgery to death were gathered by a checklist referring to the patient records, telephone records, and laboratory and pathological records. The data were analyzed by Kaplan-Meier and Log-rank tests.Findings:In this study, 26 patients with a mean age of 56.00 ± 15.26 years were enrolled. 53.8 percent were men and the rest were women. Number of metastases was between two and three. No deaths due to surgery (within 30 days after surgery) occured. After resection of pulmonary metastases, one-year patient survival rate was 48 percent percent; three-year survival was not obsereved in our patients (maximum 900 days). History of hepatectomy because of previous liver metastases and pathologic findings of primary colorectal cancer had no effect on survival rate. Among the factors related to lung metastasis, only the existence of multiple metastases was related significantly with reduction of survival rate (P = 0.049).Conclusion:Colorectal cancer patients with resectionable pulmonary metastasis can be of relatively high survival rate; but one-year survival rate is lower in patients with more metastases.Background:5-year survival rate of patients undergoing surgical resection of pulmonary metastases from colorectal cancer have been reported variable. Nowadays, there is not a standard guide for selecting patients for lung metastases resection. This study aimed to identify prognostic factors determining overall survival rate of patients after resection of lung metastases in colorectal cancer.Methods: In this cross-sectional study, all the patients underwent resection of lung metastases resulting from colorectal cancer in Alzahra hospital, Isfahan in a ten year period were assessed. Information about age, sex, number of pulmonary metastases, type of metastatectomy, location of surgery, lymph node involvement and its location, size of metastases during surgery, postoperative mortality, survival, history of previous induced liver metastatectomy, pathological findings, and interval of surgery to death were gathered by a checklist referring to the patient records, telephone records, and laboratory and pathological records. The data were analyzed by Kaplan-Meier and Log-rank tests.Findings:In this study, 26 patients with a mean age of 56.00 ± 15.26 years were enrolled. 53.8 percent were men and the rest were women. Number of metastases was between two and three. No deaths due to surgery (within 30 days after surgery) occured. After resection of pulmonary metastases, one-year patient survival rate was 48 percent percent; three-year survival was not obsereved in our patients (maximum 900 days). History of hepatectomy because of previous liver metastases and pathologic findings of primary colorectal cancer had no effect on survival rate. Among the factors related to lung metastasis, only the existence of multiple metastases was related significantly with reduction of survival rate (P = 0.049).Conclusion:Colorectal cancer patients with resectionable pulmonary metastasis can be of relatively high survival rate; but one-year survival rate is lower in patients with more metastases.https://jims.mui.ac.ir/article_13350_58c9447937aa4e4c8b08a29273647713.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220The Effect of Different Ventilation Methods During Cardiopulmonary Bypass on Peri-Operative Lung Function in Patients Undergoing Cardiac SurgeryThe Effect of Different Ventilation Methods During Cardiopulmonary Bypass on Peri-Operative Lung Function in Patients Undergoing Cardiac Surgery2045205113351FAOmid AghadavoudiAssociate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.0000-0002-2251-1800Yahya AsadiMedical Student, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.Journal Article20110626Background: Cardiopulmonary bypass (CPB) during cardiac surgery has some adverse effects on pulmonary physiology by different mechanisms. This study was designed to compare the effect of different modes of ventilation applied during cardiopulmonary bypass on peri-operative respiratory parameters of the patients.Methods: After approval of Research Committee and obtaining informed consent, this randomized, double-blinded clinical trial study was conducted. 150 patients undergoing coronary artery bypass graft surgery in Chamran Heart Hospital, in Isfahan, were randomly allocated into three groups (50 patients in each group). Group 1 received CPAP with PEEP=10cmH2O, FiO2=20%. Group 2 received CPAP with PEEP=10cmH2O, FiO2=100%. Group 3 received no ventilation during bypass surgery. PaO2, PaCo2 and pH were recorded at 9 steps in 3 groups. In addition, static compliance and dynamic compliance were measured at 3 points in the 3 groups. All the data were analyzed by SPSS 17 using appropriate tests including Repeated Measures of ANOVA.Finding: The PaO2 measures were significantly higher in group (2) than the other 2 groups (p<0.001). PaO2 was lower in group (1) in comparison to other groups (p<0.001). Static Compliance and Dynamic Compliance were remarkably higher in patients of group (1) (p<0.001). There was no difference in the length of ventilation in ICU among the groups.Conclusion: This study shows that administration of PEEP with a mixture of air and oxygen during CPB in cardiac surgery has beneficial effects on peri-operative respiratory parameters in patients.Background: Cardiopulmonary bypass (CPB) during cardiac surgery has some adverse effects on pulmonary physiology by different mechanisms. This study was designed to compare the effect of different modes of ventilation applied during cardiopulmonary bypass on peri-operative respiratory parameters of the patients.Methods: After approval of Research Committee and obtaining informed consent, this randomized, double-blinded clinical trial study was conducted. 150 patients undergoing coronary artery bypass graft surgery in Chamran Heart Hospital, in Isfahan, were randomly allocated into three groups (50 patients in each group). Group 1 received CPAP with PEEP=10cmH2O, FiO2=20%. Group 2 received CPAP with PEEP=10cmH2O, FiO2=100%. Group 3 received no ventilation during bypass surgery. PaO2, PaCo2 and pH were recorded at 9 steps in 3 groups. In addition, static compliance and dynamic compliance were measured at 3 points in the 3 groups. All the data were analyzed by SPSS 17 using appropriate tests including Repeated Measures of ANOVA.Finding: The PaO2 measures were significantly higher in group (2) than the other 2 groups (p<0.001). PaO2 was lower in group (1) in comparison to other groups (p<0.001). Static Compliance and Dynamic Compliance were remarkably higher in patients of group (1) (p<0.001). There was no difference in the length of ventilation in ICU among the groups.Conclusion: This study shows that administration of PEEP with a mixture of air and oxygen during CPB in cardiac surgery has beneficial effects on peri-operative respiratory parameters in patients.https://jims.mui.ac.ir/article_13351_4d80bbc54bbd1b3beefef3e1fe1c51b6.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952812420110220Maxillary Sinus Mycetoma Due to Aspergillosis: Case ReportMaxillary Sinus Mycetoma Due to Aspergillosis: Case Report2052205713352FAMohsen MeidaniAssistant Professor, Department of infectious diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.a:2:{s:5:"en_US";s:0:"";s:5:"fa_IR";s:0:"";}Hamidreza AbtahiAssistant Professor, Department of Otolaringology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Nooshin AfsharmoghadamAssociate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.a:2:{s:5:"en_US";s:0:"";s:5:"fa_IR";s:0:"";}Nooshin AhmadiResident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Mohammad Hasan RikhtegarMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Mohammad Javad RikhtegarMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Journal Article20110319Background: Paranasal sinus aspergilloma is a rare disease of sinus which is sometimes considered as mycetoma. In this condition, there is gathering of fungal mycelium in sinus cavity without bone or vessels invasion. It presented as a chronic sinusitis with headache, nasal discharge and obstruction. Diagnosis of aspergillosis infection has often dependent on clinical judgment combined with radiologic evaluation and demonstration of the fungus in tissue specimens obtained from the presumed site of infection.Case Report: A 53-year-old man with uncontrolled insulin dependent diabetes mellitus presented with six month history of headache. He had used various drug prescribed by different physicians in the past six months without any effect. Because of progressive headache, he was admitted in the department of otolaringology and surgical debridement was done. Histopathological examination was suggestive of maxillary sinusitis with fungal ball of aspergilluma. The patient treated with itraconazole and after 6 months, he felt better with no clinical and paraclinical signs.Conclusion: Since fungal sinusitis presentation is similar to chronic sinusitis and in the other hand, the incidence of aspergillosis is increasing, the early diagnosis and treatment is important especially when the clinical and paraclinical signs are suggestive. Background: Paranasal sinus aspergilloma is a rare disease of sinus which is sometimes considered as mycetoma. In this condition, there is gathering of fungal mycelium in sinus cavity without bone or vessels invasion. It presented as a chronic sinusitis with headache, nasal discharge and obstruction. Diagnosis of aspergillosis infection has often dependent on clinical judgment combined with radiologic evaluation and demonstration of the fungus in tissue specimens obtained from the presumed site of infection.Case Report: A 53-year-old man with uncontrolled insulin dependent diabetes mellitus presented with six month history of headache. He had used various drug prescribed by different physicians in the past six months without any effect. Because of progressive headache, he was admitted in the department of otolaringology and surgical debridement was done. Histopathological examination was suggestive of maxillary sinusitis with fungal ball of aspergilluma. The patient treated with itraconazole and after 6 months, he felt better with no clinical and paraclinical signs.Conclusion: Since fungal sinusitis presentation is similar to chronic sinusitis and in the other hand, the incidence of aspergillosis is increasing, the early diagnosis and treatment is important especially when the clinical and paraclinical signs are suggestive. https://jims.mui.ac.ir/article_13352_79a29dc3f7b743e9e8934b5fb40f4d47.pdf