Isfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952915120110923Effect of Exercise on Learning and Memory in Rats after Intracerebroventricular Injection of StreptozotocinEffect of Exercise on Learning and Memory in Rats after Intracerebroventricular Injection of Streptozotocin1142114913497FAMahdiehYosefiStudent of Animal Biology, Department of Basic Sciences, Isfahan Payame Noor University, Isfahan, IranParhamReisiAssistant Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranHojjatallahAlaeiProfessor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAli AsgharPilehvarianAssistant Professor of Animal Physiology, Department of Basic Sciences, Isfahan Payame Noor University, Isfahan.Journal Article20101123Background: Given the positive effects of exercise on the central nervous system, the aim of the present study was to evaluate the effects of treadmill running on learning and memory in rats with induced Alzheimer’s disease and intracerebroventricular injection of streptozotocin (STZ).Methods: Studied rats were divided in 4 groups: the sham-rest, the sham-exercise, the alzheimer-rest and the alzheimer-exercise. To produce rat Alzheimer’s model, STZ was infused in lateral ventricles of the brain. The exercise program was treadmill running with 20 m/min velocity and 0O inclination for 50 min/day, for 4 weeks. For evaluation of learning and memory in rats, passive avoidance learning test was used.Findings: Totally 37 rats in 4 groups were examined. The latency time for the first entrance to dark chamber one day and one week after shock was significantly shorter in Alzheimer–rest group comparing to Alzheimer–exercise and sham–rest groups.Conclusion: These results suggest that exercise probably is effective in prevention and alleviation of cognitive disorders in Alzheimer’s disease.Background: Given the positive effects of exercise on the central nervous system, the aim of the present study was to evaluate the effects of treadmill running on learning and memory in rats with induced Alzheimer’s disease and intracerebroventricular injection of streptozotocin (STZ).Methods: Studied rats were divided in 4 groups: the sham-rest, the sham-exercise, the alzheimer-rest and the alzheimer-exercise. To produce rat Alzheimer’s model, STZ was infused in lateral ventricles of the brain. The exercise program was treadmill running with 20 m/min velocity and 0O inclination for 50 min/day, for 4 weeks. For evaluation of learning and memory in rats, passive avoidance learning test was used.Findings: Totally 37 rats in 4 groups were examined. The latency time for the first entrance to dark chamber one day and one week after shock was significantly shorter in Alzheimer–rest group comparing to Alzheimer–exercise and sham–rest groups.Conclusion: These results suggest that exercise probably is effective in prevention and alleviation of cognitive disorders in Alzheimer’s disease.https://jims.mui.ac.ir/article_13497_e66aed023cb30fdc29ca488de67c02da.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952915120110923Effect of Exercise Therapy and Physiotherapy on Patients with Chronic Low Back PainEffect of Exercise Therapy and Physiotherapy on Patients with Chronic Low Back Pain1150115613498FASomayehNooriSchool of Physical Education, University of Isfahan, Isfahan, Iran0000-0002-8703-9316GholamaliGhasemiAssistant Professor, School of Physical Education, University of Isfahan, Isfahan, IranKhalilKhayambashiAssociate Professor, School of Physical Education, University of Isfahan, Isfahan, IranAbdolkarimKarimiAssistant Professor, School of Rehabilitation, Isfahan University of Medical Sciences, Isfahan, IranVazgenMinasianAssistant Professor, School of Physical Education, University of Isfahan, Isfahan, IranSomayehAlizamaniFaculty Member, Sheikhbahaee University, Isfahan, IranJournal Article20101121Background: The aim of present research is to compare the effects of exercise therapy and physiothe-rapy that are two common treatments for pain and disability in patients with chronic low back pain.Methods: In this research 30 patients with chronic low back pain (history of low back pain for at least 3 months) were selected. Patients allocated in two treatment groups: exercise therapy (n = 17) and physiotherapy (n = 13). Disability was evaluated using oswestry low back pain disability questionnaire (ODQ) and pain intensity was evaluated with the visual analog scale (VAS).Two groups underwent treatment for 6 weeks. Post-test was performed at the end of treatment period. Following collection of primary information and determination of different variable, covariance test with the variety factor (pre-test) in the level of α < 0.05 was used to analyze the data.Findings: Research findings did not show statistical significant difference in pain (P > 0.05) but the difference in functional disability between two groups was significant (P < 0.03).Conclusion: Our results indicate that exercise therapy is better than physiotherapy for disability im-provement in patients with low back pain. Finally, this study recommends that exercise therapy can be an effective modality to management patients with chronic low back pain.Background: The aim of present research is to compare the effects of exercise therapy and physiothe-rapy that are two common treatments for pain and disability in patients with chronic low back pain.Methods: In this research 30 patients with chronic low back pain (history of low back pain for at least 3 months) were selected. Patients allocated in two treatment groups: exercise therapy (n = 17) and physiotherapy (n = 13). Disability was evaluated using oswestry low back pain disability questionnaire (ODQ) and pain intensity was evaluated with the visual analog scale (VAS).Two groups underwent treatment for 6 weeks. Post-test was performed at the end of treatment period. Following collection of primary information and determination of different variable, covariance test with the variety factor (pre-test) in the level of α < 0.05 was used to analyze the data.Findings: Research findings did not show statistical significant difference in pain (P > 0.05) but the difference in functional disability between two groups was significant (P < 0.03).Conclusion: Our results indicate that exercise therapy is better than physiotherapy for disability im-provement in patients with low back pain. Finally, this study recommends that exercise therapy can be an effective modality to management patients with chronic low back pain.https://jims.mui.ac.ir/article_13498_c28cccd4486efb636bd7d753ca52d487.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952915120110923Effect of Supplementary Vitamin D on Improvement of Glycemic Parameters in Patients with Type 2 DiabeticEffect of Supplementary Vitamin D on Improvement of Glycemic Parameters in Patients with Type 2 Diabetic1157116413499FASaeedBehradmaneshAssistant Professor, Department of Internal Medicine, School of Medicine, Shahrekord University of Medical Sciences,
Shahrekord, IranKamranRoudiniResident, Department of Internal Medicine and Endocrinology, School of Medicine, Shahrekord University of Medical Sciences,
Shahrekord, IranAzarBaradaranAssociate Professor, Department of of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-7058-6367Journal Article20110222Background: Type 2 diabetes mellitus (T2DM) and Vitamin D deficiency, are too common disorders in the world. Various investigations argues the association between two diseases, however, findings are contradictory and controversial. The aim of the present study was to examine the effect of complementary vitamin D supplementation on improvement of various glycemic parameters in T2DM.Methods: In a double blind randomized clinical trial, 60 persons of T2DM patients were selected and divided into 2 groups with 30 patients. Group 1 were treated with oral Vitamin D (50,000 unit /week for 12 week), and group 2 were treated with placebo drug.Findings: The age of studied population were between 34 to 76 years and the mean age was 55 ± 10.7 years. Age, sex, BMI and serum levels of HbA1c and 25(OH) vitamin D were not significantly differ-ent between two groups before the study. After 12 weeks treatment intervention, no significant differ-ence was found in serum HbA1c and lipids between two groups.Conclusion: In this study weekly vitamin D supplementation for 12 weeks had not significant decre-mental effect on HbA1c and lipid profiles, however, further studies needs to evaluate clinical useful-ness of our findings.Background: Type 2 diabetes mellitus (T2DM) and Vitamin D deficiency, are too common disorders in the world. Various investigations argues the association between two diseases, however, findings are contradictory and controversial. The aim of the present study was to examine the effect of complementary vitamin D supplementation on improvement of various glycemic parameters in T2DM.Methods: In a double blind randomized clinical trial, 60 persons of T2DM patients were selected and divided into 2 groups with 30 patients. Group 1 were treated with oral Vitamin D (50,000 unit /week for 12 week), and group 2 were treated with placebo drug.Findings: The age of studied population were between 34 to 76 years and the mean age was 55 ± 10.7 years. Age, sex, BMI and serum levels of HbA1c and 25(OH) vitamin D were not significantly differ-ent between two groups before the study. After 12 weeks treatment intervention, no significant differ-ence was found in serum HbA1c and lipids between two groups.Conclusion: In this study weekly vitamin D supplementation for 12 weeks had not significant decre-mental effect on HbA1c and lipid profiles, however, further studies needs to evaluate clinical useful-ness of our findings.https://jims.mui.ac.ir/article_13499_4d230b683bf9840553ae57f4acc96e81.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952915120110923The Relation between Neurologic and Adaptive Capacity Scoring with Maternal, Fetal and Anesthetic Factors. in Cesarean Born NeonatesThe Relation between Neurologic and Adaptive Capacity Scoring with Maternal, Fetal and Anesthetic Factors. in Cesarean Born Neonates1165117413500FAMaryamSharifiStudent of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranSeyed JalalHashemiProfessor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-9848-440XMitraJabalameliAssociate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20110611Background: Neurologic and adaptive capacity scoring (NACS) is considered as a screening test for recognizing the central nervous system depression due to the effects of medications in neonates. This test is able to show the neurologic and behavioral changes even in the presence of normal apgar score. The aim of this study was to determine the relationship between the NACS with maternal, fetal and anesthetic factors. Methods: This descriptive analytical cross sectional study was performed on 100 cesarean born neonates. Data were collected simply and by filling the questionnaire. NACS score ≤ 34 supposed as abnormal and score ≥ 35 supposed as normal.Findings: NACS mean Score in 3 different times (15 min, 2 hours and 24 hours after birth) was more than 35. The correlation between anesthetic method and the used drugs with NACS was significant. There were also a significant relation between NACS and studied fetal factors (gestational age, apgar score in 1.5 minutes, sex) and also some maternal factors (gravity, maternal heart disease, twin or multifetal pregnancies). Conclusion: The normal NACS in 3 different times (15 min, 2 hours and 24 hours after birth) showed a good maternal, fetal and anesthetic conditions in Shahid Beheshti hospital, Isfahan. Spinal anesthesia with lidocaine is recommended for caesarean section instead of general anesthesia for having a better NACS.Background: Neurologic and adaptive capacity scoring (NACS) is considered as a screening test for recognizing the central nervous system depression due to the effects of medications in neonates. This test is able to show the neurologic and behavioral changes even in the presence of normal apgar score. The aim of this study was to determine the relationship between the NACS with maternal, fetal and anesthetic factors. Methods: This descriptive analytical cross sectional study was performed on 100 cesarean born neonates. Data were collected simply and by filling the questionnaire. NACS score ≤ 34 supposed as abnormal and score ≥ 35 supposed as normal.Findings: NACS mean Score in 3 different times (15 min, 2 hours and 24 hours after birth) was more than 35. The correlation between anesthetic method and the used drugs with NACS was significant. There were also a significant relation between NACS and studied fetal factors (gestational age, apgar score in 1.5 minutes, sex) and also some maternal factors (gravity, maternal heart disease, twin or multifetal pregnancies). Conclusion: The normal NACS in 3 different times (15 min, 2 hours and 24 hours after birth) showed a good maternal, fetal and anesthetic conditions in Shahid Beheshti hospital, Isfahan. Spinal anesthesia with lidocaine is recommended for caesarean section instead of general anesthesia for having a better NACS.https://jims.mui.ac.ir/article_13500_357861553d0db7307050a24ce16a8c64.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952915120110923Comparison of the Results of Polymerase Chain Reaction and Oxacillin Agar Dilution Methods in Determining Resistance to Methicillin in Isolated Staphylococcus Aureus at Alzahra Hospital, Isfahan, IranComparison of the Results of Polymerase Chain Reaction and Oxacillin Agar Dilution Methods in Determining Resistance to Methicillin in Isolated Staphylococcus Aureus at Alzahra Hospital, Isfahan, Iran1175118213501FASayed AsgharHavaeiAssociate Professor, Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMohsenKarbalaeizadeh BabakiMSc Student, Student Research Committee, Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranEbtehajPishvaAssociate Professor, Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20111005Background: Staphylococcus aureus is an important infectious bacterium. The pathogenicity of this bacterium is critical in both society and hospital. It is a human normal flora that exists in the upper respiratory tract of 25% of healthy individuals. It causes a wide spectrum of diseases ranging from skin infections to severe infections including septicemia, endocarditis, pneumonia, and skin abscess. S. aureus is a considerable factor of severe infections in both society and hospital. Methicillin resistant S. aureus (MRSA) strains have high mortality rates. Therefore, the rate of MRSA must be quickly identified and controlled with treating measures.Methods: A total number of 114 strains of S. aureus were obtained from the specimens at Alzahra Hospital, Isfahan, Iran. Minimum inhibitory concentration (MIC) of oxacillin for MRSA was performed with agar dilution method and eventually polymerase chain reaction (PCR) for mecA gene.Findings: Out of 114 samples, 35 isolates had mecA gene that were assessed with agar dilution method. According to the Clinical and Laboratory Standards Institute (CLSI), MIC of oxacillin in agar dilution method was 8 µg/ml and results was recorded. MecA gene PCR was conducted for all strains and the results were compared with agar dilution method. From resistant isolates, 4% of the strains had mecA gene but were susceptible to methicillin in phenotypic method. Conclusion: Our study showed agar dilution method to be more sensitive and specific than disk diffusion method. PCR is the best method to indentify susceptible and resistant strains to methicillin. Some strains were susceptible to oxacillin in phenotypic method but their mecA gene was identified with PCR.Background: Staphylococcus aureus is an important infectious bacterium. The pathogenicity of this bacterium is critical in both society and hospital. It is a human normal flora that exists in the upper respiratory tract of 25% of healthy individuals. It causes a wide spectrum of diseases ranging from skin infections to severe infections including septicemia, endocarditis, pneumonia, and skin abscess. S. aureus is a considerable factor of severe infections in both society and hospital. Methicillin resistant S. aureus (MRSA) strains have high mortality rates. Therefore, the rate of MRSA must be quickly identified and controlled with treating measures.Methods: A total number of 114 strains of S. aureus were obtained from the specimens at Alzahra Hospital, Isfahan, Iran. Minimum inhibitory concentration (MIC) of oxacillin for MRSA was performed with agar dilution method and eventually polymerase chain reaction (PCR) for mecA gene.Findings: Out of 114 samples, 35 isolates had mecA gene that were assessed with agar dilution method. According to the Clinical and Laboratory Standards Institute (CLSI), MIC of oxacillin in agar dilution method was 8 µg/ml and results was recorded. MecA gene PCR was conducted for all strains and the results were compared with agar dilution method. From resistant isolates, 4% of the strains had mecA gene but were susceptible to methicillin in phenotypic method. Conclusion: Our study showed agar dilution method to be more sensitive and specific than disk diffusion method. PCR is the best method to indentify susceptible and resistant strains to methicillin. Some strains were susceptible to oxacillin in phenotypic method but their mecA gene was identified with PCR.https://jims.mui.ac.ir/article_13501_e50f835e19789b8995b9bc6f8779f4e2.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952915120110923DNA Repair Capability of MCF-7 after Exposure to Substituted Benzofuran Derivatives with Aromatase Inhibitory EffectsDNA Repair Capability of MCF-7 after Exposure to Substituted Benzofuran Derivatives with Aromatase Inhibitory Effects1183119313502FAMahmoudEtebariAssistant Professor, Department of Pharmacology And Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran0000-0003-2219-0602Ghadam AliKhodarahmiAssociate Professor, Department of Medicinal Chemistry And Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, IranAbbasJafarian DehkordiProfessor, Department of Pharmacology And Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, IranZariNokhodianMSc Student, Department of Pharmacology And Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-8399-7349Journal Article20111012Background: Benzofuran derivatives block the aromatase enzyme and reduce estrogen production. It was shown that although the cytotoxicity of these compounds could be in part due to the aromatase inhibition, DNA damage may also be involved. This study was designed to assess whether these derivatives can induce DNA damage, and to evaluate if such damage could be repaired.Methods: MCF-7 cells were exposed to the compounds at different concentrations to find a concentration sufficient to induce DNA damage. Cells were exposed for 2 hours to genotoxic concentration of compounds and recovered for 17 and 24 hours. The comet assay was used to examine DNA damage. Analysis of variance (ANOVA) followed by Tukey's test were used for statistical analysis at a significance level of P < 0.05.Findings: The genotoxic effects of benzofuran derivatives were observed in 70, 75, and 200 nM for the 4-fluoro, 4-chloro, and 2-methoxy derivatives of benzofuran, respectively. The genotoxic concentration of 2-methyl derivatives and the unsubstituted derivatives of benzofuran were 300 and 1000 nM, respectively. The DNA damages caused by 4-fluoro, 4-chloro and 2-methyl derivatives of benzofuran recovered after 24 hours while those caused by 2-methoxy and unsubstituted derivatives of benzofuran recovered after 17 hours. Conclusion: The benzofuran phenylmethyl imidazole and its 4-fluoro, 4-chloro, 2-methoxy, and 2-methyl derivatives are genotoxic. Moreover, our study showed that the DNA damages caused by these substances were repairable. Therefore, if these compounds are able to pass other safety and clinical tests, they could be used as new therapeutic compounds.Background: Benzofuran derivatives block the aromatase enzyme and reduce estrogen production. It was shown that although the cytotoxicity of these compounds could be in part due to the aromatase inhibition, DNA damage may also be involved. This study was designed to assess whether these derivatives can induce DNA damage, and to evaluate if such damage could be repaired.Methods: MCF-7 cells were exposed to the compounds at different concentrations to find a concentration sufficient to induce DNA damage. Cells were exposed for 2 hours to genotoxic concentration of compounds and recovered for 17 and 24 hours. The comet assay was used to examine DNA damage. Analysis of variance (ANOVA) followed by Tukey's test were used for statistical analysis at a significance level of P < 0.05.Findings: The genotoxic effects of benzofuran derivatives were observed in 70, 75, and 200 nM for the 4-fluoro, 4-chloro, and 2-methoxy derivatives of benzofuran, respectively. The genotoxic concentration of 2-methyl derivatives and the unsubstituted derivatives of benzofuran were 300 and 1000 nM, respectively. The DNA damages caused by 4-fluoro, 4-chloro and 2-methyl derivatives of benzofuran recovered after 24 hours while those caused by 2-methoxy and unsubstituted derivatives of benzofuran recovered after 17 hours. Conclusion: The benzofuran phenylmethyl imidazole and its 4-fluoro, 4-chloro, 2-methoxy, and 2-methyl derivatives are genotoxic. Moreover, our study showed that the DNA damages caused by these substances were repairable. Therefore, if these compounds are able to pass other safety and clinical tests, they could be used as new therapeutic compounds.https://jims.mui.ac.ir/article_13502_13dfe127c6d40641c7ad9fd60ef8701d.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952915120110923Dose Distribution Analysis for Electron Beam Irregular Fields In Treatment of Superficial Tumors: A Monte Carlo StudyDose Distribution Analysis for Electron Beam Irregular Fields In Treatment of Superficial Tumors: A Monte Carlo Study1194120213503FAKhadijehBamneshinMSc Student, Department of Medical Physics and Engineering, School of Medicine And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranParvanehShokraniProfessor, Department of Medical Physics and Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMohammad BagherTavakkoliProfessor, Department of Medical Physics and Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20111015Background: In the superficial treatment with Electron beam, the Irregular radiation fields are produced because of the shield at the end of the applicator or on the surface of the body in the treatment field. In this situation the dispersion amount in irregular fields change in comparison to the regular field and causes dosimeter value changes.Methods: In this study, in order to study the effect of the shield, the simulation code BEAMnrc based on EGSnrc, which is installed on Linux OS, was used for simulating and calculating R90 irregular fields, which were made of shielding square fields of (15´15)(20´20)(25´25) CM. For experimental measurement a type P silicon diode manufactured by Scanditronix was used. R90 simulated irregular fields were compared with dosimetric amounts gained by methods of equivalent open field and open field.Findings: The depth of R90 changed as a result of change in the shielded area and the shape of the field and there was no specific order in its increasing or decreasing. The amount of change in irregular fields with 6 mega electron volt energy compared to an equivalent field are less than 2 millimeters and compared to an open field are less than 1 millimeter.Conclusion: The study proved that using the open field method is better than the equivalent field method in measuring R90.Background: In the superficial treatment with Electron beam, the Irregular radiation fields are produced because of the shield at the end of the applicator or on the surface of the body in the treatment field. In this situation the dispersion amount in irregular fields change in comparison to the regular field and causes dosimeter value changes.Methods: In this study, in order to study the effect of the shield, the simulation code BEAMnrc based on EGSnrc, which is installed on Linux OS, was used for simulating and calculating R90 irregular fields, which were made of shielding square fields of (15´15)(20´20)(25´25) CM. For experimental measurement a type P silicon diode manufactured by Scanditronix was used. R90 simulated irregular fields were compared with dosimetric amounts gained by methods of equivalent open field and open field.Findings: The depth of R90 changed as a result of change in the shielded area and the shape of the field and there was no specific order in its increasing or decreasing. The amount of change in irregular fields with 6 mega electron volt energy compared to an equivalent field are less than 2 millimeters and compared to an open field are less than 1 millimeter.Conclusion: The study proved that using the open field method is better than the equivalent field method in measuring R90.https://jims.mui.ac.ir/article_13503_6ca973f198a5d9b68fb6cf60a53156e8.pdfIsfahan University of Medical SciencesJournal of Isfahan Medical School1027-75952915120110923Can Soy Products Affect on Inflammation Level? A Review on the Current EvidenceCan Soy Products Affect on Inflammation Level? A Review on the Current Evidence1203121513504FAMaryam SadatMiraghajaniDepartment of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan,
IranLeilaAzadbakhtAssociate Professor, Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food
Sciences, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20110706Background: Inflammation has a specific role in the pathology of several diseases. Recently the effects of soy and soy components such as isoflavones have been reported on the inflammatory markers. In this review we aimed to describe the existing evidence on the effect of soybeans and soy components on inflammatory indices. Methods: We searched Scirus and PubMed databases with keywords “soy”, “inflammatory factors”, “oxidative Stress”, “soy isoflavones”, “inflammatory cytokines”. Totally, 30 studies were extracted. Animal, human and in vitro studies with case-control and clinical trial designs related to soy or soy components and inflammatory markers were included in this review.Findings: Laboratory data have been shown that soy isoflavones have anti inflammatory effects significantly. Most animal studies suggest that soy components can reduce inflammatory levels. However, in human studies soy consumption had inconsistent effects on inflammatory factors. Conclusion: Moderate consumption of soy might decrease serum inflammatory markers levels. Meta analysis is needed for further evaluation in this regard.Background: Inflammation has a specific role in the pathology of several diseases. Recently the effects of soy and soy components such as isoflavones have been reported on the inflammatory markers. In this review we aimed to describe the existing evidence on the effect of soybeans and soy components on inflammatory indices. Methods: We searched Scirus and PubMed databases with keywords “soy”, “inflammatory factors”, “oxidative Stress”, “soy isoflavones”, “inflammatory cytokines”. Totally, 30 studies were extracted. Animal, human and in vitro studies with case-control and clinical trial designs related to soy or soy components and inflammatory markers were included in this review.Findings: Laboratory data have been shown that soy isoflavones have anti inflammatory effects significantly. Most animal studies suggest that soy components can reduce inflammatory levels. However, in human studies soy consumption had inconsistent effects on inflammatory factors. Conclusion: Moderate consumption of soy might decrease serum inflammatory markers levels. Meta analysis is needed for further evaluation in this regard.https://jims.mui.ac.ir/article_13504_f18374bf891c9af64c8570448824202d.pdf