Bone mineral density in patients with Beta-Thalassemia Major in Qazvin

Document Type : Original Article(s)

Authors

1 Pediatric Endocrinologist, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

2 Professor of Pediatrics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

Abstract

Abstract Thalassemia is the most common hereditary anemia and beta thalassemia major is the most severe form of this syndrome. Patients' surveillance will be increase by the use of desferal, blood transfusion, and bone marrow transplantation, but simoultaneously the mineral bone density can be decreased. Background: In this cross- sectional study 63 patients with ß- thalassemia major   (12-36 years old) were enrolled. Physical examination, laboratory tests, bone radiography and bone density measurements done for every one. Then, datas analyzed with SPSS software, and Chi- square test. Methods: 34 (56%) out of 63 patients were male. Patients mean age was        20/89 ± 5/01 years old, 11 ones (18%) were 12-17 and 52 patients (82%) were 17-36 years old. Mean of weight, height and BMI were 45/56 ± 9/2 Kg, 157 ± 10/43 cm and 19/87 ± 2/8 kg/m2 respectively. Impaired puberty observed in 27 ones (32/9%) and 40 (77%) had Low bone mineral density. The relationship between low bone mineral density and puberty status was significant (P < 0/05). Findings: This study shows a significant relation between low bone density (osteopenia, Osteoporosis) and impaired puberty in B. thalassemia major patients. Conclusion: Major thalassemia, Bone mineral density, Osteopenia, Osteoporosis, puberty. Key words:

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History

  • Receive Date: 07 November 2010
  • Revise Date:
  • Accept Date: 06 April 2022

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