The Correlation between Allergic Rhinitis and Migraine

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Neurology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

2 Associate Professor, Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

3 Assistant Professor, Department of Biostatistics, Otolaryngology-Head and Neck Surgery Research Center, School of Nursing, Guilan University of Medical Sciences, Rasht, Iran

4 Assistant Professor, Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

5 Student of Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Abstract

Background: Migraine and allergic rhinitis (AR) are two common causes of headache and facial pain in which inflammatory mediators with vasoactive function play important roles. This study aimed to determine the frequency of migraine in AR patients.Methods: In a case-control study performed from June to December 2010 in patients referred to ear, nose and throat (ENT) clinic of a university hospital in Rasht, Iran, 46 AR patients with positive skin prick tests were compared with 60 subjects without AR signs and symptoms and negative skin tests. In both groups, history of migraine was assessed according to IHS (International Headache Society) criteria. Data was analyzed by chi-square and Fisher's exact tests in SPSS17.Findings: The case group included 14 male and 32 female patients with a mean age of 31.17 ± 8.31 years. In addition, 23 male and 37 female individuals with a mean age of 37.58 ± 12.63 years constituted the control group. The prevalence of migraine in the case and control groups was 37% and 5%, respectively. The differences in the prevalence of migraine and migraine without aura between cases and controls were significant (P = 0.001 for both conditions, odds ratio for migraine = 11.244, 95% CI: 2.428-53.76). In contrast to individuals over 40 years old, in subjects younger than 30 and those between 30-39 years old, the difference in the prevalence of migraine (with and without aura) was not significant. Conclusion: The prevalence of migraine, especially without aura, in allergic patients is higher than non-allergic subjects and this correlation is more significant with increasing age.

Keywords

References

  1. Boes CJ, Capobianco DJ, Ctrer FM, Dodick DW, Garza I, Swanson JW. Headache and Other craniofacial pain. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J, editors. Neurology in Clinical Practice. 5th ed. Oxford: Butterworth-Heinemann; 2007. p. 2026-42.
  2. Mehle ME. Allergy and migraine: is there a connection? Curr Opin Otolaryngol Head Neck Surg 2008; 16(3): 265-9.
  3. Silberstein SD, Lipton RB, Goadsby PJ. Headach in Clinical Practice. 2nd ed. Informa Healthcare; 2002.
  4. Richard L, MabryBradley F. Allergic rhinitis. In: Cummings CW, Haughey BH, Thomas JR, Harker LA, Flint PW, editors. Otolaryngology Head & Neck Surgery. 4th ed. New York: Mosby; 2004. p. 981-9.
  5. Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008; 122(Suppl 2): S1-84.
  6. Abbasi Ranjbar Z. Prevalence of allergic rhinitis among children in Rasht. Journal of Guilan university of medical sciences, 2004; 14(53): 56-62.
  7. Eross E, Dodick D, Eross M. The Sinus, Allergy and Migraine Study (SAMS). Headache 2007; 47(2): 213-24.
  8. Tepper SJ. New thoughts on sinus headache. Allergy Asthma Proc 2004; 25(2): 95-6.
  9. Davey G, Sedgwick P, Maier W, Visick G, Strachan DP, Anderson HR. Association between migraine and asthma: matched case-control study. Br J Gen Pract 2002; 52(482): 723-7.
  10. Mortimer MJ, Kay J, Gawkrodger DJ, Jaron A, Barker DC. The prevalence of headache and migraine in atopic children: an epidemiological study in general practice. Headache 1993; 33(8): 427-31.
  11. Aamodt AH, Stovner LJ, Langhammer A, Hagen K, Zwart JA. Is headache related to asthma, hay fever, and chronic bronchitis? The Head-HUNT Study. Headache 2007; 47(2): 204-12.
  12. Gurkan F, Ece A, Haspolat K, Dikici B. Parental history of migraine and bronchial asthma in children. Allergol Immunopathol (Madr ) 2000; 28(1): 15-7.
  13. Mehle ME, Kremer PS. Sinus CT scan findings in "sinus headache" migraineurs. Headache 2008; 48(1): 67-71.
  14. Perry BF, Login IS, Kountakis SE. Nonrhinologic headache in a tertiary rhinology practice. Otolaryngol Head Neck Surg 2004; 130(4): 449-52.
  15. de Souza CD, Fragoso YD, Coelho FM, Pereira MM. Asthma plus migraine in childhood and adolescence: prophylactic benefits with leukotriene receptor antagonist. Headache 2002; 42(10): 1044-7.
  16. Riccioni G, Bucciarelli T, Mancini B, Di IC, D'Orazio N. Antileukotriene drugs: clinical application, effectiveness and safety. Curr Med Chem 2007; 14(18): 1966-77.
  17. Ku M, Silverman B, Prifti N, Ying W, Persaud Y, Schneider A. Prevalence of migraine headaches in patients with allergic rhinitis. Ann Allergy Asthma Immunol 2006; 97(2): 226-30.
  18. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. Cephalalgia 1988; 8(Suppl 7): 1-96.
  19. Gazerani P, Pourpak Z, Ahmadiani A, Hemmati A, Kazemnejad A. A correlation between migraine, histamine and immunoglobulin e. Scand J Immunol 2003; 57(3): 286-90.
  20. Kemper RH, Meijler WJ, Korf J, Ter Horst GJ. Migraine and function of the immune system: a meta-analysis of clinical literature published between 1966 and 1999. Cephalalgia 2001; 21(5): 549-57.
  21. Bellamy JL, Cady RK, Durham PL. Salivary levels of CGRP and VIP in rhinosinusitis and migraine patients. Headache 2006; 46(1): 24-33.
  22. Schuller DE, Cadman TE, Jeffreys WH. Recurrent headaches: what every allergist should know. Ann Allergy Asthma Immunol 1996; 76(3): 219-26.
  23. Levy D, Burstein R, Strassman AM. Mast cell involvement in the pathophysiology of migraine headache: A hypothesis. Headache 2006; 46(Suppl 1): S13-S18.
  24. Jackson A, Dial A. Sinus headache in an ENT setting. Proceedings of the Amer Acad Neurology, Annual Meeting; 2004 Apr 9-16,. Miami, Florid.
  25. Cady RK, Schreiber CP. Sinus headache: a clinical conundrum. Otolaryngol Clin North Am 2004; 37(2): 267-88.
  26. Dadgarnia MH, Atighechi S, Baradaranfar MH. The response to sodium valproate of patients with sinus headaches with normal endoscopic and CT findings. Eur Arch Otorhinolaryngol 2010; 267(3): 375-9.
  27. Martin VT, Taylor F, Gebhardt B, Tomaszewski M, Ellison JS, Martin GV, et al. Allergy and immunotherapy: are they related to migraine headache? Headache 2011; 51(1): 8-20.
Journal of Isfahan Medical School
Volume 29, Issue 161 - Serial Number 161
September and October 2011
Pages 1822-1830

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History

  • Receive Date: 05 April 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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