تأثیر تمرین هوازی تداومی و تناوبی بر سطوح سرمی گالکتین 3 و مقاومت به انسولین در رت‌های صحرایی نژاد ویستار مبتلا به دیابت بارداری

نوع مقاله : Original Article(s)

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران

2 استاد، گروه علوم ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران

3 دانشیار، گروه فیزیولوژی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران

4 استادیار، گروه علوم ورزشی، دانشکده‌ی ادبیات و علوم انسانی، دانشگاه زابل، زابل، ایران

چکیده

مقاله پژوهشی




مقدمه: دیابت بارداری (Gestational diabetes mellitus) GDM، یکی از شایع‌ترین بیماری‌های متابولیک در زنان باردار است. به نظر می‌رسد تشخیص زودهنگام آن تأثیر قابل توجهی بر رشد جنین، زایمان و دوره‌ی نوزادی دارد. هدف از این مطالعه، تأثیر تمرین هوازی تداومی و تناوبی بر سطوح سرمی گالکتین 3 و مقاومت به انسولین در رت‌های صحرایی مبتلا به دیابت بارداری بود.
روش‌ها: 60 سر رت صحرایی ماده‌ی ویستار (با وزن 10 ± 220 گرم) به طور تصادفی در 6 گروه شاهد (Ctr)، گروه شاهد+تمرین هوازی تداومی (Ctr+CON)، گروه شاهد+تمرین هوازی تناوبی (Ctr+INT)، گروه دیابت بارداری (GDM)، گروه دیابت بارداری+تمرین هوازی تداومی (GDM+CON)، گروه دیابت بارداری+تمرین هوازی تناوبی (GDM+INT) قرار گرفتند. گروه‌های تمرین در دوران بارداری تحت تمرینات با تردمیل قرار گرفتند. سطوح مقاومت به انسولین و گالکتین 3 اندازه‌گیری شد. از آزمون آماری ANOVA یک راهه برای تجزیه و تحلیل آماری استفاده شد.
یافته‌ها: غلظت گالکتین 3 سرم در گروه GDM به طور معنی‌داری بیشتر از گروه Ctr بود، از طرفی سطح گالکتین3 در گروه‌های GDM+CON و GDM+INT بطور معنی‌داری کمتر از گروه GDM بود. وزن گروه GDM بطور معنی‌داری بیشتر از گروه Ctr و گروه‌های تمرین در روز بیستم بارداری بود. سطوح مقاومت به انسولین در گروه‌های GDM+CON و GDM+INT بطور معنی‌داری کمتر از گروه GDM بود.
نتیجه‌گیری: نتایج این مطالعه نشان داد که هر دو نوع تمرین هوازی تداومی و تناوبی در بهبود دیابت بارداری مؤثر بودند، اما تفاوت معنی‌داری بین دو مدل تمرین وجود نداشت. علاوه بر این همبستگی مثبت و معنی‌داری بین گالکتین3 و GDM یافت شد که ممکن است به عنوان یک عامل بالقوه برای پیش‌بینی پیشرفت GDM استفاده شود.

تازه های تحقیق

احمد اربابی: Google Scholar, PubMed

مهدی مقرنسی: Google Scholar, PubMed

کلیدواژه‌ها

عنوان مقاله [English]

Effect of Continuous and Intermittent Aerobic Training on Serum Galectin3 and Insulin Resistance in Wistar Rats with Gestational Diabetes Mellitus

نویسندگان [English]

  • Ahmad Arbabi 1
  • Mehdi Mogharnasi 2
  • Hamed Fanaei 3
  • Javad Nakhzari Khodakheir 4
1 PhD Student of Exercise Physiology, Department of Sport Sciences, University of Birjand, Iran
2 Professor of Exercise Physiology, Department of Sport Sciences, University of Birjand, Iran
3 Associate Professor, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran
4 Assistant Professor, Department of Physical Education and Sport Sciences, School of Human Sciences, University of Zabol, Zabol, Iran
چکیده [English]

Background: Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. This study aims to present the potential and significance of Galectin3 (GAL3) in the pathogenesis of GDM.
Methods: Sixty female Wistar rats (weighting 220 ± 10g) were randomly assigned into six groups: control (Ctr) group, control+continuous aerobic training (Ctr+CON) group, control+intermittent aerobic training (Ctr+INT) group, gestational diabetes mellitus (GDM) group, GDM+continuous aerobic training (GDM+CON) group, GDM+intermittent aerobic training (GDM+INT) group. Exercise groups underwent treadmill exercise during pregnancy. Levels of insulin resistance and galectin3 were measured.
Findings: Serum galectin3 concentration in the GDM group was significantly higher than Ctr. On the other hand, the galectin3 level in the GDM+CON and GDM+INT groups was considerably lower than in the GDM group. The weight of the GDM group was significantly higher than the Ctr and training groups on the 20th day of gestation. Insulin resistance levels in the GDM+CON and GDM+INT groups were significantly lower than in the GDM group.
Conclusion: The study results demonstrate that both continuous and intermittent training effectively improved GDM. However, there was no statistically significant difference between the two training models. In addition, a significant positive correlation was found between galectin3 and GDM. It may be used as a potential factor to predict the development of GDM.

کلیدواژه‌ها [English]

  • Diabetes
  • Gestational
  • Galectin 3
  • Insulin resistance
  • Aerobic exercise

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مجله دانشکده پزشکی اصفهان
دوره 42، شماره 764
هفته 4، خرداد
خرداد و تیر 1403
صفحه 317-324

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سابقه مقاله

  • تاریخ دریافت: 02 تیر 1403
  • تاریخ پذیرش: 01 مرداد 1403

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