The Effects of Oral Lactocare® Administration on Gastrointestinal Disorders Caused by Chemotherapy in Children

Document Type : Original Article(s)

Authors

1 Instructor, Student Research Committee, Khomein University of Medical Sciences, AND Instructor, Department of Basic Sciences, Khomein University of Medical Sciences, Khomein, Iran

2 Associate Professor, Department of Pediatrics, Iran University of Medical Sciences, Tehran, Iran

3 Assistant Professor, Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran

4 Medical Student, Department of Pediatrics, Iran University of Medical Sciences, Tehran, Iran

5 Assistant Professor, Department of Biochemistry and Genetics, Semnan University of Medical Sciences, Semnan, Iran

Abstract

Background: Chemotherapy is one of the most common treatments for children with cancer, which is associated with gastrointestinal diseases. Synbiotics are supplements containing probiotics and prebiotics that potentially have a significant effect in modulating the intestinal microbiota.
Methods: This double-blind clinical trial was conducted on 88 children with non-hematological neoplasms. Patients were randomly divided into two groups to receive Lactocare® and placebo (46 patients in the Lactocare group and 42 patients in the placebo group). Patients receive the drugs twice a day for 14 days. The number of times diarrhea, vomiting, nausea, and constipation caused by chemotherapy were evaluated after the start of receiving Lactocare and placebo until the end of the study.
Findings: In the Lactocare® group, the duration of diarrhea and constipation (in days) after the first week was significantly less than in the placebo group (P < 0.05). There was no significant difference between the two groups in terms of the severity of nausea and vomiting (P > 0.05). The placebo group in our study was 1.37 times more likely to have diarrhea compared to the LactoCare®-treatment group (P = 0.041, odds ratio: 1.37; confidence interval: 1.05-3.31).
Conclusion: In this study, the use of Lactocare® reduced diarrhea and constipation caused by chemotherapy in patients. It seems that the use of Lactocare® synbiotic supplement is an easy and effective way to reduce diarrhea and constipation caused by chemotherapy in patients with neoplasms.

Highlights

Kazem Ghaffari: Google Scholar, PubMed

Aziz Eghbali: Google Scholar, PubMed

Atefeh Khalilpour: PubMed

Aygin Eghbali: PubMed

Ali Ghasemi: Google Scholar, PubMed

Keywords

Main Subjects

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Journal of Isfahan Medical School
Volume 41, Issue 748
4th Week, February
January and February 2024
Pages 1109-1117

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History

  • Receive Date: 23 August 2023
  • Accept Date: 26 February 2024

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