بررسی توصیفی روند رشد کودکان مبتلا به کم کاری مادرزادی تیرویید مراجعه کننده به مرکز تحقیقات غدد و متابولیسم دانشگاه علوم پزشکی اصفهان

نوع مقاله : Original Article(s)

نویسندگان

1 استادیار، گروه اپیدمیولوژی و آمار زیستی، دانشکده‌ی بهداشت، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استاد، مرکز تحقیقات غدد و متابولیسم، مرکز تحقیقات ارتقای سلامت کودکان، گروه کودکان، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 پزشک عمومی، پژوهشگر، مرکز تحقیقات ارتقای سلامت کودکان، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

4 دانشجوی پزشکی، کمیته‌ی تحقیقات دانشجویی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

5 استاد، مرکز تحقیقات ارتقای سلامت کودکان، گروه کودکان، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

6 مرکز بهداشت استان اصفهان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

7 استاد، گروه داخلی، مرکز تحقیقات غدد و متابولیسم، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: با توجه به این که تاکنون در ایران، مطالعه‌ای جهت بررسی روند رشد کودکان مبتلا به کم کاری مادرزادی تیرویید انجام نگرفته است، همچنین با توجه به شیوع بالای این بیماری در کودکان ایران به خصوص شهر اصفهان و اجرای چند ساله‌ی برنامه‌ی غربال‌گری نوزادی و درمان این بیماران پس از تشخیص، مطالعه‌ی حاضر با هدف بررسی توصیفی روند رشد کودکان مبتلا به کم کاری مادرزادی تیرویید انجام گرفت.روش‌ها: در این مطالعه‌ی آینده نگر توصیفی 760 کودک (متولدین سال‌های 1381 تا 1388) مبتلا به کم کاری مادرزادی تیرویید مراجعه کننده به مرکز تحقیقات غدد و متابولیسم اصفهان به روش نمونه‌گیری در دسترس و با در نظر گرفتن معیارهای ورود و خروج، وارد مطالعه شدند. متغیرهای قد، وزن، دور سر و شاخص توده‌ی بدنی این کودکان مورد بررسی قرار گرفت؛ به این نحو که جهت توصیف اطلاعات موجود، صدک‌های 3، 15، 50، 85 و 97 به تفکیک سن و جنس و در مقاطع سنی مختلف محاسبه شد و با مقادیر مشابه کودکان سالم گزارش شده از سوی سازمان جهانی بهداشت مقایسه گردید.یافته‌ها: در این مطالعه مشاهده شد که اعداد صدک‌های هر یک از متغیرها، در کودکان مبتلا با کودکان طبیعی متفاوت است، اما این تفاوت در صدک‌های بالاتر کمتر بود. از طرفی با افزایش سن اختلاف کاهش می‌یافت.نتیجه‌گیری: می‌توان چنین نتیجه‌گیری کرد که با درمان کودکان مبتلا به کم کاری تیرویید مادرزادی روند رشد این کودکان طبیعی می‌شود. هر چند در مورد وزن دیرتر و در مورد دور سر زودتر چنین اتفاقی می‌افتد.

کلیدواژه‌ها


عنوان مقاله [English]

The Descriptive Findings of Growth Status among Children with Congenital Hypothyroidism Referred to Isfahan Endocrine and Metabolism Research Center

نویسندگان [English]

  • Awat Feizi 1
  • Mahin Hashemipour 2
  • Silva Hovsepian 3
  • Zeynab Amirkhani 4
  • Roya Kelishadi 5
  • Kamal Heydari 6
  • Ali Sajadi 6
  • Massoud Amini 7
1 Assistant Professor, Department of Biostatics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
2 Professor, Endocrine and Metabolism Research Center, Child Health Promotion Research Center, Department of Pediatric, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 General Practitioner, Research Assistant, Child Health Promotion Research Center, Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Student of Medicine, Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
5 Professor, Child Health Promotion Research Center, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
6 Isfahan Health Centre, Isfahan University of Medical Sciences, Isfahan, Iran
7 Professor,Department of Endocrinology, Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Considering the high prevalence of congenital hypothyroidism (CH) in Iran and particularly Isfahan, Iran, and according to the findings of CH screening program which was implemented during recent years and lack of studies evaluating the treatment outcome of diagnosed patients, the aim of this study was to descriptively evaluate the growth status of children with CH.Methods: In this prospective cohort study, 760 CH neonates who were diagnosed and followed up during CH screening program (2002-9) in Isfahan were enrolled. They were selected by convenient sampling method. Height, weight, head circumferences and body mass index (BMI) of the studied patients were measured. In addition, the 3rd, 15th, 50th, 85th and 97th percentiles of the studied variables according to sex and age groups were determined and descriptively compared with corresponding values suggested by the World Health Organization (WHO).Findings: The percentiles of weight, height and head circumferences of the studied children with CH were significantly different from the WHO values. The observed differences were less significant in higher percentiles. The differences reduced during the follow-up and they were lower in older ages. Conclusion: The findings of this study indicated that proper treatment of neonates with CH would improve the growth delay of patients during follow-up. However, normal growth of head circumference would be achieved earlier than weight.

کلیدواژه‌ها [English]

  • Congenital hypothyroidism
  • Head circumference
  • Height
  • Weight
  • Body Mass Index
  • Neonatal screening
  • Growth
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