The Effect of Hydroalcoholic Extract of Capparis Spinosa on Quality of Sperm and Rate of Testosterone Following Induction of Diabetes in Rats

Document Type : Original Article (s)

Authors

1 Assistant Professor, Herbal Medicine Research Center, Yasouj University of Medical Sciences, Yasouj, Iran

2 Department of Physiology, Islamic Azad University, Fars Science and Research Branch, Shiraz, Iran

3 Associate Professor, Cellular and Molecular Research Centre, Yasouj University of Medical Sciences, Yasouj, Iran

Abstract

Background: It has been shown that reproductive system is affected by diabetes mellitus. The aim of this research was assessing the effect of Capparis spinosa on reproductive parameters and the rate of testosterone after induction of diabetes in rats.Methods: 48 Wistar rats (200-250 g) were divided into 6 groups of 8. The shame and diabetic control groups received distilled water. The shame and two diabetic treatment groups received 20, 20 and 30 mg/kg hydroalcohoic extract of Capparis spinosa, respectively. The sixth group received 100 mg/kg of vitamin E. All groups treated for 21 days; then, the rate of testosterone hormone and qualities of sperm were measured.Findings: The mean values of fast mobility and normal morphology of sperm increased significantly (64.25 ± 15.31 and 70.38 ± 19.78 percent, respectively) in diabetic treatment rats received 30 mg/kg of Capparis spinosa compared to control diabetic group. Although, the rate of testosterone increased in diabetic treatment groups, but was not significant.Conclusion: The hydroalcohoic extract of Capparis spinosa could improve the reproductive parameters in diabetic rats.

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 264 - Serial Number 264
November and December 2014
Pages 2042-2057

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History

  • Receive Date: 15 September 2013
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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