Effect of Vitamin D Supplementation on the Treatment of Pulmonary

Document Type : Original Article(s)

Authors

1 Associate Professor, Department of Infection Diseases, School of Medicine and Infection Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Infection Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Isfahan Provice Health Center, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Resident, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

5 Research Assistant, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Tuberculosis (TB) is an infective and important disease in the world. TB is controlled in developed countries but it is one of the important problems in developing countries like Iran. Various researches have linked lack of vitamin D to be the main cause of TB in many individuals. Therefore, theory of the effect of vitamin D supplements in treatment of TB has been made that if confirmed, it helps to treatment of TB and decrease in costs. This clinical trial and accidental double-blind study was performed to clear the controversies on this issue.Methods: A clinical trial study was performed on 90 cases with TB (up than 21 age) referred to 5 centers of health in Isfahan with no history of treatment for the disease. They were selected by method of simple-non probable; then they divided into two groups, one under routine standard drugs and the other, under vitamin D supplement and routine standard drugs. The data consisted of name, age, sex, date, and results of gathered sputum smears in a questionnaire. Consequently, sputum smears were obtained at the end of the weeks 2nd, 4th, 6th and 8th.Finding: There was no significant difference between the two groups in amount of getting negative sputum smear in the weeks 2nd, 4th, 6th and 8th.Conclusion: The role of vitamin D is confirmed in cure of pulmonary TB in cellular and molecular level. However, more studies are necessary to confirm effects of vitamin D supplement in treatment of TB.

Keywords

References

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Journal of Isfahan Medical School
Volume 28, Issue 113 - Serial Number 113
September and October 2011
Pages 781-786

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History

  • Receive Date: 02 March 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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