اثر درمانی پلاسمای غنی از پلاکت (PRP) در جوان‌سازی پوست: مزایا و معایب

نکویی مارنانی, نیوشا; جعفری, فریبا; نیلفروش‌زاده, محمدعلی

اثر درمانی پلاسمای غنی از پلاکت (PRP) در جوان‌سازی پوست: مزایا و معایب

نوع مقاله : مقاله مروری

نویسندگان

¹ مرکز تحقیقات پوست و سلول‌های بنیادی، دانشگاه علوم پزشکی تهران، تهران، ایران

² استاد، مرکز تحقیقات بیماری‌های پوستی و سالک، دانشگاه علوم پزشکی اصفهان، اصفهان و مرکز تحقیقات پوست و سلول‌های بنیادی، دانشگاه علوم پزشکی تهران، تهران، ایران

³ دانشیار، مرکزتحقیقات پوست و سلول‌های بنیادی، دانشگاه علوم پزشکی تهران، تهران، ایران

چکیده

هدف اصلی اغلب روش‌های زیبایی، یافتن روشی مطمئن با کمترین عوارض جانبی برای رفع پیری و جوان‌سازی پوست می‌باشد. به دلیل شباهت مسیر بهبود زخم و جوان‌سازی پوست، روش‌های متنوعی مانند لیزر Ablative وNon-ablative در همین راستا برای جوان‌سازی پوست به کار رفته‌اند. یکی از روش‌هایی که در سال‌های اخیر مورد توجه عموم و متخصصین قرار گرفته است، تزریق پلاسمای غنی از پلاکت (PRP یا Platelet-rich plasma) می‌باشد. در این مطالعه، با مروری بر مکانیسم‌های مولکولی فرایند پیری و جوان‌سازی پوست، شواهد و مستندات اثربخشی پلاسمای غنی از پلاکت بر این فرایند، به همراه عوارض جانبی و خطرهای احتمالی آن مورد بررسی قرار می‌گیرد. از آن‌جایی که پلاسمای غنی از پلاکت، حاوی غلظت بالایی از عوامل رشد می‌باشد، می‌تواند فرایند بهبود زخم را تسریع کند. با این وجود، غلظت بالای عوامل رشد، می‌تواند مسیرهای سیگنالی ایجاد تومورهای پوستی را القا نماید. از این نظر، تزریق پلاسمای غنی از پلاکت می‌تواند با خطر احتمالی ایجاد تومورهای پوستی همراه باشد و لازم است، آثار و عوارض دراز مدت آن در مطالعات آینده‌نگر گسترده مورد ارزیابی قرار گیرد.

کلیدواژه‌ها

عنوان مقاله [English]

Platelet-Rich Plasma (PRP) Therapy in Skin Rejuvenation: Benefits and Adverse Influences

نویسندگان [English]

Nioosha Nekooie-Marnany ¹
Fariba Jaffary ²
Mohammad Ali Nilforoushzadeh ³

¹ Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

² Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan AND Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

³ Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

چکیده [English]

A safe and effective rejuvenation method with few side effects is one of the main purposes of most of the aesthetic procedures. As wound healing process is similar to rejuvenation mechanisms, diverse methods such as ablative and non-ablative laser have been applied to meet this target. A recent method that has remarkably taken experts' and technicians’ attention is platelet-rich plasma (PRP) injection. This article reviews molecular mechanisms of aging and rejuvenation. It also evaluates clinical documents regarding the effects of platelet-rich plasma in rejuvenation beside its possible side effects. Because of high concentration of growth factors in platelet-rich plasma, it potentially can accelerate wound healing. However, there is a concern about the relation between the high level of growth factors and induction of signaling cascades of tumors. Long-term platelet-rich plasma outcomes need to be more investigated in cohort studies.

کلیدواژه‌ها [English]

Platelet-rich plasma
Rejuvenation
Wound healing
Growth factors
Cancer

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