اثر پیش‌درمان تمرین هوازی بر برخی از شاخص‌های استرسی ریه در برابر سمیت ناشی از دوکسوروبیسین

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 استادیار، گروه تربیت بدنی، دانشگاه پیام نور، تهران، ایران

2 استاد، گروه فیزیولوژی ورزشی، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

چکیده

مقدمه: هدف از انجام پژوهش حاضر، تعیین تأثیر پیش‌درمان تمرین هوازی بر شاخص‌های استرسی و التهابی (Heat shock protein یا HSP70، Superoxide dismutase یا SOD، Malondialdehyde یا MDA و C-reactive protein یا CRP) ناشی از القای دوکسوروبیسین در بافت ریه‌ی موش‌های صحرایی نر سالمند بود.روش‌ها: 16 سر موش صحرایی نر به طور تصادفی به دو گروه شاهد (سالمند + دوکسوروبیسین) و مورد (سالمند + دوکسوروبیسین + تمرین) تقسیم شدند. گروه تمرین به مدت سه هفته با سرعت 17-15 متر/دقیقه و زمان 39-25 دقیقه و پنج جلسه در هفته روی نوار گردان دویدند. آزمودنی‌ها 24 ساعت پس از آخرین جلسه‌ی تمرین، محلول دوکسوروبیسین (20 میلی‌گرم/کیلوگرم) دریافت کردند. 48 ساعت بعد، بافت‌برداری انجام شد. برای تحلیل داده‌ها، از نرم‌افزار SPSS و آزمون One- way ANOVA و آزمون تعقیبی Scheffe استفاده شد.یافته‌ها: سه هفته تمرین هوازی فقط موجب افزایش معنی‌دار HSP70 و SOD و کاهش معنی‌دار MDA بافت ریه‌ی گروه مورد نسبت به گروه شاهد گردید.نتیجه‌گیری: به نظر می‌رسد تمرینات ورزشی قبل از درمان با دوکسوروبیسین در سالمندان، به احتمال زیاد تأثیر خود را از طریق تغییرات پروتئین‌های حفاظتی سلول در مهار یا کاهش آسیب‌های اکسایشی ایفا می‌کنند.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Pretreatment of Aerobic Training on Some of the Pulmonary Stress Indices against the Toxicity of Doxorubicin

نویسندگان [English]

  • Seyedeh Zolaikha Hashemi-Chashmi 1
  • Valiolla Dabidiroshan 2
1 Assistant Professor, Department of Sport Physiology, Payame Noor University, Tehran, Iran
2 Professor, Department of Sport Physiology, School of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran
چکیده [English]

Background: The purpose of this study was to determine the effect of pretreatment of aerobic training on stress and inflammatory indices [heat shock protein-70 (HSP70), superoxide dismutase (SOD), malondialdehyde (MDA) and C-reactive protein (CRP)] induced by doxorubicin in lung tissue of aging male rats.Methods: 16 male rats were randomly divided into aging + doxorubicin (AD) and aging + doxorubicin + training (ADT) groups. The training group ran on a treadmill for three weeks at speeds of 15-17 m/minute for 25-39 minutes and five sessions a week. Subjects received doxorubicin (20 mg/kg) 24 hours after the last training session. The biopsy was taken 48 hours later. Data were analyzed using one-way ANOVA and Scheffe post hoc test via SPSS software.Findings: Three weeks of the aerobic training only resulted in a significant increase of HSP70 and SOD, and decrease of MDA in the lung tissue in the training group compared to the control group.Conclusion: Doing exercises before treatment with doxorubicin appear to be effective in elderly people, probably due to changes in the protective proteins of the cell in inhibiting or reducing oxidative damage.

کلیدواژه‌ها [English]

  • Pretreatment
  • Aerobic training
  • Pulmonary oxidative stress
  • Aging

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مجله دانشکده پزشکی اصفهان
دوره 37، شماره 559 - شماره پیاپی 559
بهمن و اسفند 1398
صفحه 1422-1427

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سابقه مقاله

  • تاریخ دریافت: 11 خرداد 1398
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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