نقش فعالیت بدنی در تنظیم عوامل رشد عصبی (Brain-Derived Neurotrophic Factor یا BDNF و Nerve Growth Factor یا NGF) در مبتلایان به Multiple Sclerosis: مرور نظام‌مند

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه شهید چمران، اهواز، ایران

2 استادیار، گروه فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه شهید چمران، اهواز، ایران

3 دانشیار، گروه نورولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی جندی‌شاپور، اهواز، ایران

4 دانشجوی دکتری تخصصی، گروه فیزیولوژی ورزشی، دانشکده‌ی علوم انسانی، دانشگاه تربیت مدرس، تهران، ایران

چکیده

مقدمه: Multiple Sclerosis (MS) یک عامل ناتوانی عصبی شایع در بزرگ‌سالان و یک بیماری خود ایمن با مکانیسم ناشناخته و پیچیده است که با آسیب آکسونی و دمیلینه شدن نورون‌های سیستم عصبی مرکزی مشخص می‌شود. یکی از مکانیسم‌های مطرح در بیماری‌زایی MS، عوامل رشد عصبی هستند. از طرفی، فعالیت بدنی می‌تواند یکی از مکانیسم‌های مؤثر در تنظیم عوامل رشد عصبی در افراد مبتلا به MS باشد. هدف از انجام این مطالعه‌ی مروری، بررسی نظام‌مند تأثیر فعالیت بدنی بر عوامل رشد عصبی در افراد مبتلا به MS است.روش‌ها: مطالعه‌ی مروری نظام‌مند، بر اساس واژه‌های سیستم Medical subject headings در پایگاه‌های اطلاعاتی Pubmed، Googlescholar، Sciencedirect و Springer به زبان انگلیسی و پایگاه‌های اطلاعاتی Magiran و SID به زبان فارسی انجام شد. معیارهای انتخاب مطالعه، شامل فارسی یا انگلیسی بودن زبان مقاله، بازه‌ی زمانی 15 سال اخیر، تمرکز صرف مطالعه بر روی مبتلایان به MS، مداخله‌ی ورزشی یا فعالیت بدنی در مبتلایان به MS به همراه ارزیابی عوامل رشد عصبی بود. روش کار مطالعات، با استفاده از مقیاس Physiotherapy evidence database ارزیابی شد.یافته‌ها: از بین 161 مطالعه‌ی مورد بررسی، 9 مطالعه شرایط مورد نظر را داشتند. میانگین شاخص Physiotherapy evidence database مطالعات مرور شده 55/6 بود. مطالعات اغلب از Brain-derived neurotrophic factor (8 مطالعه) و Nerve growth factor (4 مطالعه) استفاده کرده بودند. نتایج اغلب مطالعات نشان داد که فعالیت بدنی منجر به افزایش Brain-derived neurotrophic factor می‌شود، اما تغییرات معنی‌دار Nerve growth factor را به دنبال ندارد.نتیجه‌گیری: فعالیت بدنی منظم، می‌تواند به عنوان یک روش درمانی کمکی در بیماری MS مورد توجه باشد و از طریق تنظیم عوامل رشد عصبی و به خصوص Brain-derived neurotrophic factor، بر روند بیماری MS مؤثر باشد؛ هر چند برای اثبات قطعی این یافته، انجام مطالعات بیشتری مورد نیاز است.

کلیدواژه‌ها

عنوان مقاله [English]

The Role of Physical Activity on Modulation of Nerve Growth Factors [Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF)] in Patients with Multiple Sclerosis: A Systematic Review

نویسندگان [English]

  • Motahareh Mokhtarzadeh 1
  • Rohollah Ranjbar 2
  • Nastaran Majdinasab 3
  • Raoof Negaresh 4
1 MSc Student, Department of Sport Physiology, School of Sport Sciences, Shahid Chamran University, Ahvaz, Iran
2 Assistant Professor, Department of Sport Physiology, School of Sport Sciences, Shahid Chamran University, Ahvaz, Iran
3 Associate Professor, Department of Neurology, School of Medicine, Jundishapour University of Medical Sciences, Ahvaz, Iran
4 PhD Student, Department of Sport Physiology, School of Humanity, Tarbiat Modares University, Tehran, Iran
چکیده [English]

Background: Multiple sclerosis is a common cause of neurological disability in adults and a disease with largely unknown and complex etiology that characterizes with axonal damage and central nervous system demyelination. One of the mechanisms involved in the pathogenesis of multiple sclerosis is nerve growth factors. On the other hand, physical activity can be one of the effective mechanisms in modulation of neural growth factors in patients with multiple sclerosis. The purpose of this review was the systematic investigation of the effect of physical activity on nerve growth factors in ppatients with multiple sclerosis.Methods: A systematic review was made based on Medical Subject Headings system word on the databases of Pubmed, Googlescholar, Sciencedirect and Springer in English and the databases of Magiran and (SID) in Persian. The inclusion criteria were studies published in English or Persian, during a 15-year period, only in patients with multiple sclerosis, with sport or physical activity intervention, and assessment of nerve growth factors. Methodology assessed through Physiotherapy Evidence Database scale.Findings: Between 161 reviewed studies, 9 that had the criteria were selected. Physiotherapy Evidence Database scale mean was 6.55. Studies had mostly assessed brain-derived neurotrophic factor (BDNF) (8 studies) and nerve growth factor (NGF) (4 studies). Most of the results indicated that physical activity lead to an increase in brain-derived neurotrophic factor but is not associated with significant changes in nerve growth factor.Conclusion: Although further studies are needed, regular physical activity can be considered as an adjuvant therapy in multiple sclerosis. It can affect multiple sclerosis disease process through regulation of nerve growth factors.

کلیدواژه‌ها [English]

  • Physical Activity
  • Multiple Sclerosis
  • Brain-derived neurotrophic factor
  • Nerve growth factor

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مجله دانشکده پزشکی اصفهان
دوره 35، شماره 438
مرداد و شهریور 1396
صفحه 842-854

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  • تاریخ دریافت: 20 فروردین 1396
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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