بروسلا: بیماری‌زایی، واکنش سیستم ایمنی و واکسن

نوع مقاله : مقاله مروری

نویسندگان

1 استادیار، گروه میکروب‌شناسی و ایمنی‌شناسی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی کاشان، کاشان، ایران

2 دانشیار، مرکز تحقیقات بیولوژی مولکولی، دانشگاه علوم پزشکی بقیه‌اله (عج)، تهران، ایران

چکیده

باکتری‌های جنس بروسلا، پاتوژن‌هایی داخل سلولی هستند که می‌توانند در داخل ماکروفاژهای بدن میزبان خود، تکثیر و به بقای خود ادامه دهند که حاصل آن مشکلات بسیاری برای میزبان به وجود خواهد آورد. نتایج مطالعات اخیر پیشرفت‌هایی در زمینه‌ی چگونگی بقا و تکثیر داخل سلولی این باکتری را نشان می‌دهد. در این مقاله، آخرین یافته‌ها در این زمینه مورد مرور و بررسی قرار می‌گیرد. همچنین واکنش ایمنی بدن میزبان به این پاتوژن و استراتژی‌های جدید به کار رفته به منظور ساخت واکسن علیه این باکتری، بررسی می‌شود. 

کلیدواژه‌ها

عنوان مقاله [English]

Brucella: Pathogenesis, Immune System Response and Vaccine

نویسندگان [English]

  • Amir Ghasemi 1
  • Reza Ranjbar 2
1 Assistant Professor, Department of Microbiology and Immunology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
2 Associate Professor, Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
چکیده [English]

Bacteria of the genus Brucella are intracellular pathogens capable of surviving and replicating within macrophages of mammalian hosts and are resistance to killing in professional phagocytic cells which control survival and chronic infection. Recent advances have shed light on virulence factors and host functions involved at various stages of the Brucella intracellular life cycle. This review focuses on how this pathogen uses multiple strategies to circumvent macrophage defense mechanisms and generate an organelle permissive for replication. In addition, we discuss about host immune responses to Brucella and new strategies used to produce an efficient vaccine against Brucella infection.

کلیدواژه‌ها [English]

  • Brucella
  • Vaccine
  • Pathogenesis
  • Macrophage

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مجله دانشکده پزشکی اصفهان
دوره 32، شماره 295 - شماره پیاپی 295
مرداد و شهریور 1393
صفحه 1197-1215

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  • تاریخ دریافت: 25 آبان 1392
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