آنتی‌اکسیدان‌‌ها و بهبود عملکرد سیستم ایمنی در بیماران آلوده به ویروس HIV: یک مقاله‌ی مروری

نوع مقاله : Review Article

نویسندگان

1 کارشناس، گروه تغذیه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استادیار، گروه آمار و اپیدمیولوژی، دانشکده‌ی بهداشت، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 دانشجوی کارشناسی، کمیته‌ی تحقیقات دانشجویی، گروه تغذیه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

4 دانشیار، مرکز تحقیقات امنیت غذایی، گروه تغذیه‌ی جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: آمار جهانی بیانگر رشد سریع شیوع ویروس نقص ایمنی انسانی (Human Immunodeficiency virus یا HIV) در جهان است. مطالعات بسیاری در زمینه‌ی عوامل مرتبط با سندرم نقص ایمنی اکتسابی (Acquired immune deficiency syndrome یا AIDS) و شیوع HIV انجام گرفته است که بخشی از آن‌‌ها به بعد تغذیه‌ای این بیماری اختصاص دارد. ضعف و ناتوانی ناشی از دریافت ناکافی مواد غذایی به دلیل بی‌اشتهایی، عدم جذب مناسب مواد مغذی در سطح روده منجر به تشدید ضعف جسمانی افراد آلوده به HIV شده که این ضعف منجر به پیشرفت علایم بیماری ایدز و حملات بیشتر عفونت‌‌های فرصت‌طلب می‌شود. عوامل تغذیه‌ای و متابولیکی به طور قابل توجهی در ضعف و مرگ و میر بیماران مبتلا به ایدز دخیل هستند. پیشرفت بیماری در بدن انسان منجر به تحریک سیستم ایمنی و افزایش استرس اکسیداتیو و به دنبال آن کاهش سطح آنتی‌اکسیدان‌‌ها‌ی پلاسمای خون می‌شود. بنابراین برخورداری از یک رژیم غذایی مناسب و یا استفاده‌ی از مکمل‌‌های آنتی‌اکسیدانی به عنوان یک درمان مؤثر و کم هزینه در کنار سایر درمان‌‌های دارویی منجر به تقویت سیستم ایمنی و بهبود وضعیت بیماران می‌شود. در مطالعه‌ی مروری حاضر به بررسی مطالعات صورت گرفته در زمینه‌ی اثر آنتی‌اکسیدان‌‌ها بر سیستم ایمنی و در نهایت اثر بر روند پیشرفت بیماری ایدز در افراد آلوده به ویروس HIV پرداخته شده است.

کلیدواژه‌ها

عنوان مقاله [English]

Antioxidants and Improvement of Immune System Function in HIV infected Patients: A Review Article

نویسندگان [English]

  • Narges Jani 1
  • Ghasem Yadegarfar 2
  • Maryam Hajishafiyee 3
  • Leila Azadbakht 4
1 BSc, Department of Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Assistant Professor, Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
3 BSc Student, Student Research Committee, Department of Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
4 Associate Professor, Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
چکیده [English]

Background: World’s statistics show the fast growth of prevalence of Human Immunodeficiency Virus (HIV) in all over the world. A great deal of studies relevant to the all effective factors of HIV/AIDS (Acquired immune deficiency syndrome), some parts of them related to nutrition. Disability to eat and digest foods and to absorb nutrients from food is one of the results of weakness and wasting of all HIV infected patients. This kind of weakness affects to intensification of signs of disease and increase risk of opportunistic infections. Nutritional and metabolic factors significantly affect morbidity and mortality of HIV/AIDS patients. The progression of disease in human body is causing to stimulate the immune system and increase the oxidative stress and also decrease the antioxidants level of plasma.Consequently using diversity diet or antioxidant supplementation as an effective and no expensive treatment is useful along the other clinical treatments to improve immune system and welfare the patient’s status. In this review article we try to examine studies which are related to the effect of antioxidants on the immune system and finally the effects of them on progression of disease in HIV infected patients. 

کلیدواژه‌ها [English]

  • Human Immunodeficiency virus (HIV)
  • Antioxidant
  • Oxidative Stress
  • Immune system

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مجله دانشکده پزشکی اصفهان
دوره 29، شماره 135 - شماره پیاپی 135
خرداد و تیر 1390
صفحه 445-456

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سابقه مقاله

  • تاریخ دریافت: 01 آذر 1389
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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