The Effects of 12 Weeks of Caloric Restriction with and without Aerobic Exercise Training on Peroxidant and Antioxidants Indicators in Postmenopausal Women with Type 2 Diabetes

Document Type : Original Article (s)

Authors

1 Department of Physical Education and Sport Sciences, Islamic Azad University, Najafabad Branch, Isfahan, Iran

2 Assistant Professor, Department of Physical Education and Sport Sciences, Islamic Azad University, Najafabad Branch, Isfahan, Iran

3 Assistant Professor, Department of Community and Preventive Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran

Abstract

Background: Obese and sedentary lifestyles are associated with increased oxidative stress. The purpose of the present study was to assess the effects of 12 weeks of caloric-restricted diet with and without aerobic exercise training on peroxidant and antioxidants indicators in overweight or obese postmenopausal women with type 2 diabetes.Methods: In a randomized, controlled trial study, 72 overweight or obese, postmenopausal, sedentary women with type 2 diabetes (age: 53.7 ± 1.2 years and body mass index: 33.9 ± 1.7 kg/m2) were randomized to a diet only group (n = 37) with moderate energy-restricted high-protein diet (include ~5500 kJ/day), or to a diet plus exercise group (n = 35). In addition to the moderate energy-restricted diet program for the planned weight loss of 8-14 kg), subjects in diet only group performed an exercise training program included 30-55 minutes of aerobic exercise, 5 times in week with 50-75% of observed maximal heart rate for 12 weeks. Body weight, body mass index (BMI), waist to hip ratio (WHR), body fat (%), cardiorespiratory fitness, peroxidant and antioxidants indicators including malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were measured before and after intervention. Repeated measures ANOVA were used for data analysis.Findings: After 12 weeks, significant reductions in body weight, BMI, WHR, body fat (%), MDA levels and significant increases in VO2 peak, SOD and CAT levels were observed in both groups (P < 0.050 for all). However, these changes were different in body weight, BMI and VO2 peak between the two groups (P < 0.050 for all).Conclusion: The results of the present study showed that moderate energy-restricted diet program combined with regular aerobic exercise can improve peroxidant and antioxidant balance in overweight or obese postmenopausal women with type 2 diabetes and can prevent exercise-induced oxidative stress.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 322 - Serial Number 322
January and February 2015
Pages 100-113

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History

  • Receive Date: 16 November 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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