Anti-MCV Changes in the Treatment of Rheumatoid Arthritis and its Relation to Disease Activity

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Resident, Department of Internal Medicine, School of Medicine And Student Research Committee , Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Department of Community and Preventive Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Associate Professor, Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: In some studies Anti-mutated citrullinated vimentin antibodies (Anti-MCV) was known as a specific marker to diagnose and evaluate the process of rheumatoid arthritis (RA). In this study our aim was to evaluate the relationship between the disease activity score (DAS28) and serum titer of Anti-MCV in patients with rheumatoid arthritis.Methods: This study was a clinical trial in which 80 patients with RA were enrolled. All patients were treated for 3 months. ESR, Anti-MCV and DAS28 were measured before and after the treatment. Data was analyzed be Paired t-test and χ2.Findings: Anti-MCV titer was decreased significantly after treatment (P < 0.001). Pearson test showed a significant correlation between DAS28 and Anti-MCV titer (P < 0.05).Conclusion: Our findings suggested that Anti-MCV should be one of the serelogic tests for evaluating DAS28 in patients with rheumatoid arthritis.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 153 - Serial Number 153
July and August 2011
Pages 1270-1276

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History

  • Receive Date: 27 March 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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