تأثیر فعالیت هوازی با شدت متوسط بر رفتار تشنجی القا شده با پنتیلن تترازول در موش‌های باردار

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشجوی دکتری تخصصی رفتار حرکتی، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه رازی، کرمانشاه، ایران

2 استادیار، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه رازی، کرمانشاه، ایران

3 استادیار، مرکز تحقیقات علوم دارویی، دانشکده‌ی داروسازی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران

4 استادیار، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه رازی کرمانشاه، کرمانشاه، ایران

چکیده

مقدمه: صرع، یکی از اختلالات نورولوژیکی عمده و معمول می‌باشد. مشاهده شده است که فعالیت بدنی می‌تواند یک درمان مکمل برای درمان تشنج باشد. با این وجود، بیشتر تحقیقات تجربی در ارتباط با فعالیت بدنی و صرع بر روی حیوانات نر انجام شده و نیاز است که در حیوانات ماده و به خصوص در دوران بارداری به واسطه‌ی عوارض نامطلوب تشنج در دوران بارداری بر موالید، تأثیرات فعالیت بدنی بر میزان تشنج بررسی شود. به همین منظور، مطالعه‌ی حاضر جهت بررسی تأثیر تمرین هوازی در دوران بارداری بر میزان تشنج القا شده با پنتیلن‌تترازول (Pentylenetetrazol یا PTZ) طراحی شد.روش‌ها: موش‌های ماده‌ی کیندل‌ شده به 4 گروه شامل 1) موش‌های باردار تحت درمان با PTZ در روزهای 19-14 بارداری هر 48 ساعت یک‌بار و بدون فعالیت جسمانی در بارداری، 2) موش‌های باردار تحت درمان با PTZ در روزهای 19-14 بارداری و هر 48 ساعت یک بار با فعالیت هوازی با شدت متوسط از ساعت 3-1 بعدازظهر، 3) موش‌های‌ غیر باردار تحت درمان با PTZ در روزهای جفت شده با گروه موش‌های باردار و بدون فعالیت جسمانی و 4) موش‌های غیر باردار تحت درمان با PTZ در روزهای جفت شده با گروه موش‌های باردار با فعالیت هوازی با شدت متوسط از ساعت 3-1 بعدازظهر تقسیم شدند. شدت فعالیت تشنجی به مدت 30 دقیقه پس از تزریق PTZ اندازه‌گیری شد.یافته‌ها: تمرین هوازی، سبب کاهش شدت تشنج در موش‌های ماده می‌شود و تفاوتی میان شدت تشنج در موش‌های ماده‌ی باردار و غیر باردار مشاهده نشد.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Moderate-Intensity Aerobic Activity on Pentylenetetrazol-Induced Epileptic Behaviors in Pregnant Mice

نویسندگان [English]

  • Ayoob َُSabaghi 1
  • Ali Heirani 2
  • Amir Kiani 3
  • Namdar Yousofvand 4
1 PhD Student in Motor Behavior, School of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran
2 Assistant Professor, School of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran
3 Assistant Professor, Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Assistant Professor, Department of Biology, School of Sciences, Razi University, Kermanshah, Iran
چکیده [English]

Background: Epilepsy is one of the major and common neurological disorders. It has been observed that physical activity can be a complementary therapy to treat seizures. Nevertheless, studies regarding the effects of physical activity on epilepsy are largely performed on males, and there is little information on the extent of these effects in females, especially during pregnancy; since it appears that seizures during pregnancy have adverse effects on development of the offspring. The present study was designed to investigate the effect of aerobic training during pregnancy on pentylenetetrazol (PTZ)-induced seizure in mice.Methods: The kindled female mice were divided into 4 groups; 1. the pregnant mice treated with pentylenetetrazol between the fourteenth and nineteenth days of pregnancy once in 48 hours, without physical training during the pregnancy; 2. the pregnant mice treated with pentylenetetrazol between the fourteenth and nineteenth days of pregnancy once in 48 hours, with moderate-intensity aerobic training during pregnancy between 1:00 and 3:00 p.m.; 3. the non-pregnant mice treated with pentylenetetrazol in yoked days with pregnant mice group and without physical training; and 4. the non-pregnant mice treated with pentylenetetrazol in yoked days with pregnant mice group with moderate-intensity aerobic training between 1:00 and 3:00 p.m. The seizure activity was measured for half an hour after pentylenetetrazol injection.Findings: The aerobic training reduced seizure severity in female mice; and there was no difference in seizure severity between pregnant and non-pregnant mice.Conclusion: These findings revealed that middle-intensity aerobic training could be a complementary therapeutic strategy to reduce the severity of seizure, especially in pregnancy.

کلیدواژه‌ها [English]

  • Seizure
  • Pregnancy
  • Aerobic Exercise
  • Mouse

مراجع

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مجله دانشکده پزشکی اصفهان
دوره 36، شماره 480 - شماره پیاپی 480
خرداد و تیر 1397
صفحه 535-541

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سابقه مقاله

  • تاریخ دریافت: 03 اردیبهشت 1397
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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