تأثیرات بیولوژیک و ضد سرطانی کورکومین (Curcumin)

نوع مقاله : مقاله مروری

نویسندگان

1 کارشناس ارشد، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه اصفهان، اصفهان، ایران

2 دانشیار، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه اصفهان و گروه زیست فن‌آوری سلولی، مرکز تحقیقات علوم سلولی، پژوهشکده‌ی زیست فن‌آوری جهاد دانشگاهی، پژوهشگاه رویان، اصفهان، ایران

3 دانشیار، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه اصفهان، اصفهان، ایران

چکیده

زردچوبه، نام عامیانه‌ی گیاه Curcuma longa، یک ادویه‌ی هندی متعلق به خانواده‌ی زنجبیل است. زردچوبه علاوه ‌بر استفاده به عنوان ادویه و رنگ‌ دهنده به غذا، به طور سنتی برای درمان بیماری‌های مختلف از جمله التهاب مفاصل، زخم معده، زردی، ترمیم زخم، تب، تروما و بیماری‌های پوستی نیز کاربرد داشته است. خواص دارویی و اثرات بیولوژیک زردچوبه در اصل با جزء اصلی موجود در ریزوم آن یعنی Curcumin مرتبط است. در این مقاله مکانیسم‌هایی که به واسطه‌ی آن، کورکومین خواص ضد سرطانی خود را القا می‌کند، مورد بررسی قرار گرفت. کورکومین دارای خواص آنتی ‌اکسیدانی، ضد ‌باکترایی، ضد ‌قارچی، ضد ‌ویروسی، ضد ‌التهابی، ضد ‌رشدی و پروآپوپتوتیک است و پتانسیل درمانی فوق‌العاده‌ای در برابر انواعی از سرطان‌ها دارد. کورکومین فعالیت ضد سرطانی خود را از طریق مهار مسیرهای التهابی، توقف سیکل سلولی، القای آپوپتوز و مهار آنژیوژنز و متاستاز در سلول‌های سرطانی، القا می‌کند. 

کلیدواژه‌ها

عنوان مقاله [English]

Biological and Anticancer Effects of Curcumin

نویسندگان [English]

  • Elaheh Kamali 1
  • Kamran Ghaedi 2
  • Padideh Karimi 1
  • Parisa Kheradmand 1
  • Manoochehr Tavassoli 3
1 Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran
2 Associate Professor, Department of Biology, School of Sciences, University of Isfahan AND Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, Isfahan, Iran
3 Associate Professor, Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran
چکیده [English]

Turmeric is the general name for Curcuma Longa, an Indian spice belonging to the ginger family. Due to its various applications as a spice, coloring agent etc., turmeric has been used widely for the treatment of various illnesses such as arthritis, ulcers, jaundice, wounds, fever, trauma and skin diseases. The medicinal properties of turmeric are mainly due to presence of a component in the rhizome termed curcumin. The mechanisms by which curcumin exerts its anticancer effects are discussed in this paper. Curcumin has antioxidant, antibacterial, antifungal, antiviral, anti-inflammatory, antiproliferative, and proapoptotic effects. Especially, it has therapeutic applications against different cancers and could be used as a preventive agent. Curcumin induces anticancer activities by prevention of inflammation and proliferation of cancerous cells. Furthermore, it induces apoptosis and prevents metastasis. 

کلیدواژه‌ها [English]

  • Curcumin
  • Cancer
  • Inflammation
  • Bioavailability

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مجله دانشکده پزشکی اصفهان
دوره 31، شماره 265 - شماره پیاپی 265
بهمن و اسفند 1392
صفحه 2097-2112

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  • تاریخ دریافت: 20 مرداد 1392
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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