اساس ژنتیک سندرم متابولیک

نوع مقاله : مقاله مروری

نویسندگان

1 کارشناس ارشد، گروه ژنتیک، دانشکد‌ه‌ی علوم، دانشگاه شهرکرد، شهرکرد، ایران

2 -استادیار، مرکز تحقیقات فیزیولوژی کاربردی و مرکز تحقیقات رشد و نمو کودکان و پژوهشکده ی پیشگیری اولیه از بیماری های غیرواگیر و گروه ژنتیک و بیولوژی مولکولی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 استادیار، گروه ژنتیک، دانشکده‌ی علوم و پژوهشکده‌ی زیست فناوری، دانشگاه شهرکرد، شهرکرد، ایران

4 استاد، مرکز تحقیقات رشد و نمو کودکان و پژوهشکده ی پیشگیری اولیه از بیماری های غیرواگیر و گروه کودکان، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

سندرم متابولیک یکی از اختلالات رایج در کودکان است که با مجموعه‌ای از فاکتورهای خطر از قبیل چاقی، افزایش قند خون، تری‌گلیسرید و فشار خون و کاهش لیپوپروتئین با چگالی بالا (High-density lipoprotein یا HDL) همراه است. این اختلال چند عاملی به علت افزایش خطر ابتلا به دیابت نوع 2 و بیماری‌های قلبی- عروقی در بزرگ‌سالی، یکی از علل اصلی مرگ و میر در سراسر جهان است. مطالعات اخیر نشان داده است که این سندرم، شیوع بالایی در کودکان و نوجوانان چاق دارد. اتیولوژی سندرم متابولیک پیچیده است و نتیجه‌ای از برهم‌کنش عوامل ژنتیک و محیطی است که در پیشرفت چاقی، مقاومت به انسولین و چندین فرآیند التهابی تأثیر می‌گذارد. مطالعه روی جوانان ایرانی، شیوع نزدیک به 23 درصد سندرم متابولیک را نشان می‌دهد. در این مقاله‌ی مروری، به تعریف سندرم متابولیک، شیوع، علل ابتلا و مهم‌ترین ژن‌های درگیر در این اختلال اشاره می‌شود.

کلیدواژه‌ها

عنوان مقاله [English]

Genetic Basis of the Metabolic Syndrome

نویسندگان [English]

  • Hajar Miranzadeh-Mahabadi 1
  • Sayedeh Ghazaleh Fatemi 1
  • Parvaneh Nikpour 2
  • Modjtaba Emadi-Baygi 3
  • Roya Kelishadi 4
1 Department of Genetics, School of Basic Sciences, Shahrekord University, Shahrekord, Iran
2 Assistant Professor, Applied Physiology Research Center AND Child Growth and Development Research Center AND Research Institute for Primordial Prevention of Non-communicable Disease AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Assistant Professor, Department of Genetics, School of Basic Sciences AND Research Institute of Biotechnology, Shahrekord University, Shahrekord, Iran
4 Professor, Child Growth and Development Research Center AND Research Institute for Primordial Prevention of Non-communicable Disease AND Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Metabolic syndrome (MetS) is a prevalent disorder in children and it is described as a group of risk factors including obesity, increased fasting blood sugar, increased triglyceride, high blood pressure and decreased high-density lipoprotein (HDL) levels. This multifactorial disorder has been considered as one of the leading causes of mortality throughout the world and has been considered as a major risk factor for type 2 diabetes mellitus and atherosclerotic cardiovascular diseases. Recent studies have shown that the syndrome is highly prevalent among overweight children and adolescents. The etiology of the metabolic syndrome is complex, and is determined by the interaction between genetic and environmental factors and their influence on the development of obesity, insulin resistance and various inflammatory processes. Recent findings on Iranian children and adolescents show the prevalent of 23%. In this review, we looked at the definition, prevalence etiology and the main determinant genes in the development of this disorder.

کلیدواژه‌ها [English]

  • Metabolic Syndrome
  • Insulin Resistance
  • Obesity
  • Genetics

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مجله دانشکده پزشکی اصفهان
دوره 33، شماره 327 - شماره پیاپی 327
فروردین و اردیبهشت 1394
صفحه 355-367

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  • تاریخ دریافت: 13 مرداد 1393
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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