Document Type : Original Article (s)
Authors
1
PhD Student, Department of Biotechnology, School of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran
2
Associate Professor, Department of Biotechnology, School of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran
3
Professor, Department of Chemistry, School of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark
Abstract
Background: Increase in the number of peoples with cancer attract many researchers in the field of medical science to find a safe approach to treat it. The application of nanotechnology in this field is very promising, and has led to the design of nanosystems with the ability of simultaneous diagnose and therapy. Based on this, the aim of this project was the synthesis a system with functionality in multimodal diagnosis and therapy.Methods: Here, iron oxide nanoparticles were synthesized through thermal decomposition method, and were covered by Au during five irritations using Lyon's method. Finally, cyclodextrins were attached, and then polymerized on the system. The successful preparation of the system was evaluated using different characterization tests.Findings: Results showed the prosperous preparation of iron oxide nanoparticles with 15 nm mean diameter which was coated with a gold cover that increased the size to 35 nm. Moreover, the presence of cyclodextrin on the surface of system was confirmed by analytical characterization tests.Conclusion: The nanosystem introduced in this project, due to the presence of iron oxide and Au nanoparticles, has the ability to be used in two diagnostic approaches, magnetic resonance imaging (MRI) and computed tomography (CT) scan. Moreover, the presence of cyclodextrin and iron oxide in its structure allows it to be used as a hydrophobic drug delivery system, as well as in photothermal therapy and hyperthermia.
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