تأثیر تمرین تناوبی با شدت بالا بر سطوح سرمی آدیپولین و آیریزین موش‌های نر چاق مبتلا به کبد چرب غیرالکلی

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 کارشناسی ارشد، گروه فیزیولوژی ورزش، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران

2 استادیار، گروه تربیت‌بدنی، واحد پردیس، دانشگاه آزاد اسلامی، پردیس، ایران

چکیده

مقاله پژوهشی




مقدمه: مطالعات بسیاری در مورد اثرات مفید تمرینات اینتروال شدید (High-intensity interval training) HIIT بر چاقی و کبد چرب غیرالکلی اتفاق نظر دارند. پژوهش حاضر به بررسی اثر هشت هفته تمرین تناوبی با شدت بالا بر سطوح سرمی آدیپولین و آیریزین موش‌های نر چاق مبتلا به کبد چرب غیرالکلی می‌پردازد.
روش‌ها: 24 سر موش صحرایی نر نژاد ویستار به‌صورت تصادفی به سه گروه کنترل سالم؛ کنترل کبد چرب؛ HIIT کبد چرب تقسیم شدند. برای القای چاقی/کبدچرب، موش‌های صحرایی به مدت 10 هفته با رژیم غذایی پرچرب تیمار شدند. برای اطمینان از القاء بیماری از شاخص لی (Lee index) استفاده شد. موش‌های گروه تمرین، برنامه HIIT را روی تردمیل مخصوص جوندگان انجام دادند (8 هفته و 5 جلسه در هفته). 48 ساعت پس از آخرین جلسه تمرینی خونگیری انجام شد و تحلیل‌های سرمی از طریق روش الایزا انجام گرفت.
یافته‌ها: کاهش سطوح آیریزین و آدیپولین سرم در گروه کنترل کبد چرب نسبت به کنترل سالم مشاهده شد (0/001 = P). نتایج حاکی از افزایش معنی‌دار سطوح سرمی آیریزین در گروه HIIT-کبد چرب نسبت به کنترل کبد چرب بود (0/001 = P). همچنین بین گروه HIIT-کبد چرب و گروه کنترل سالم تفاوت معنی‌داری مشاهده نشد (0/05 < P).
نتیجه‌گیری: افزایش آیریزین و آدیپولین به‌عنوان مکانیسم‌هایی از اثرگذاری HIIT به‌عنوان راهی برای مقابله با اثرات مضر چاقی و کبد چرب مطرح هستند.

تازه های تحقیق

صالح رحمتی: PubMed ,Google Scholar

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of High-Intensity Interval Training on the Serum Levels of Adipulin and Irisin in Obese Male Rats with Non-Alcoholic Fatty Liver Disease

نویسندگان [English]

  • Marjan Shojaee 1
  • Saleh Rahmati 2
1 MSc, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2 Assistant Professor, Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran
چکیده [English]

Background: Many studies agree on the beneficial effects of high-intensity interval training (HIIT) on obesity and non-alcoholic fatty liver disease. The present study investigates the effect of eight weeks of high-intensity interval training on the serum levels of adipulin and irisin in obese male rats with non-alcoholic fatty liver disease.
Methods: 24 male Wistar rats were randomly divided into groups including healthy control, control fatty liver, and HIIT fatty liver. To induce obesity/fatty liver, rats were treated with a high-fat diet for 10 weeks. Lee index was used to ensure disease induction. Rats in the training group performed the HIIT program on a rodent treadmill (8 weeks and 5 sessions per week). 48 hours after the last training session, blood was taken, and serum analysis was done by ELISA method.
Findings: A decrease was seen in serum irisin and adipulin levels in the fatty liver control group compared to healthy control (P = 0.001). The results indicated a significant increase in irisin serum levels in the HIIT-fatty liver group compared to the fatty liver control (P = 0.001). Also, no significant difference was observed between the HIIT-fatty liver and the healthy control groups (P < 0.05).
Conclusion: Irisin and adipulin increase are proposed as mechanisms of HIIT effect as a way to counter the harmful effects of obesity and fatty liver.

کلیدواژه‌ها [English]

  • High-intensity interval training
  • Non-alcoholic fatty liver disease
  • Irisin
  • Obesity

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مجله دانشکده پزشکی اصفهان
دوره 41، شماره 742
هفته 2، دی
آذر و دی 1402
صفحه 971-979

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سابقه مقاله

  • تاریخ دریافت: 21 شهریور 1402
  • تاریخ بازنگری: 15 دی 1402
  • تاریخ پذیرش: 16 دی 1402

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