The Effect of Pseudocatalase/Superoxide Dismutase in Treatment of Vitiligo: A Pilot Study

Document Type : Original Article (s)

Authors

1 Associate Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran AND Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Pseudocatalase/superoxide dismutase (PSD) is a topical gel considered having therapeutic effects in vitiligo. This study was designed to evaluate the efficacy of this combination in vitiligo.Methods: This was a pilot randomized, double‑blind, placebo‑controlled trial on 46 symmetrical vitiligo lesions of limbs in 23 patients referring to dermatology clinics in Isfahan, Iran, in 2010. Patients were received this formula or placebo gels for the right and left lesions. Lesion area and degree of pigmentation were assessed at baseline and 2, 4, and 6 months later.Findings: There were no significant changes in lesion area and perifollicular pigmentation in each group (P =0.05).Conclusion: The results indicated no significant therapeutic effect for pseudocatalase/superoxide dismutase in vitiligo.

Keywords

References

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Journal of Isfahan Medical School
Volume 31, Issue 269 - Serial Number 269
November and December 2014
Pages 2309-2314

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History

  • Receive Date: 22 January 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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