التهاب و آنژیوژنز: نقش سلول‌ها و عوامل التهابی

نوع مقاله : Review Article

نویسندگان

1 دانشیار، گروه فارماکولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی زنجان، زنجان، ایران

2 استاد، مرکز تحقیقات التهاب نوروژنیک و گروه فیزیولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

چکیده

التهاب نه تنها جزیی از دفاع بدن در برابر عفونت است؛ بلکه نقش کلیدی در مکانیسم ترمیم بافتی دارد. سیتوکین‌ها و عوامل رشد آزاد شده در محل التهاب، برای ترمیم بافت ضروری هستند و مهم‌ترین عامل رگ‌زایی، عامل رشد اندوتلیال عروق (Vascular endothelial growth factor یا VEGF) است. فرایند آنژیوژنز یا رگ‌زایی، نه تنها سلول‌های اندوتلیال را درگیر می‌کند، بلکه سایر سلول‌ها از جمله سلول‌های التهابی را نیز درگیر می‌کند. کمبود اکسیژن یا هیپوکسی، مهم‌ترین محرک ایجاد این فرایندها می‌باشد که سبب تجمع ماکروفاژها و سلول‌های ایمنی می‌گردد و هم‌زمان، به عنوان اصلی‌ترین عامل محرک رگ‌‌زایی نیز مطرح شده است. تعدادی از عواملی که در ایجاد التهاب نقش دارند، به طور مستقیم یا غیر مستقیم بر رگ‌زایی نیز مؤثرند و از سوی دیگر، تعدادی از عوامل التهابی، اثرات رگ‌زایی و تعدادی دیگر اثرات ضد رگ‌زایی دارند. بنا بر این، به نظر می‌رسد ارتباط نزدیکی بین دو پدیده‌ی التهاب و رگ‌زایی وجود داشته باشد. هدف از انجام این مطالعه، بررسی ارتباط بین پدیده التهاب و رگ‌زایی و نقش سلول‌ها و واسطه‌های التهابی در فرایند رگ‌زایی می‌باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Inflammation and Angiogenesis: Role of Inflammatory Cells and Mediators

نویسندگان [English]

  • Ali Rostami 1
  • Majid Khazaei 2
1 Associate Professor, Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2 Professor, Neurogenic Inflammation Research Center AND Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Inflammation is not only a protective mechanism during tissue injury, but also has a key role in tissue repair. Cytokines and growth factors which are released during inflammation are critical for tissue repair and one of the well-known angiogenic factors is vascular endothelial growth factor. Angiogenesis involves endothelial cells as well as inflammatory cells which release several angiogenic factors. Hypoxia is the most important stimulator for inflammation and angiogenesis. Some of the inflammatory mediators are directly and/or indirectly alter angiogenesis and on the other hand, some of angiogenic factors have inflammatory effects. Therefore, it seems that there is a close relationship between angiogenesis and inflammation. This review evaluated the relationship between inflammation and angiogenesis and the role of inflammatory cells and mediators in angiogenesis process.

کلیدواژه‌ها [English]

  • Inflammation
  • Angiogenesis
  • Inflammatory cells

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مجله دانشکده پزشکی اصفهان
دوره 34، شماره 384 - شماره پیاپی 384
خرداد و تیر 1395
صفحه 612-622

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  • تاریخ دریافت: 22 فروردین 1395
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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