عوامل مؤثر بر اولین تشنج ناشی از تب در کودکان: مرور ساختار یافته

نوع مقاله : مقاله مروری

نویسندگان

1 دستیار، گروه اعصاب کودکان، بیمارستان مفید، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

2 دانشجوی دکتری، گروه آمار و اپیدمیولوژی، دانشکده‌ی بهداشت، دانشگاه علوم پزشکی مازندران، ساری، ایران

چکیده

مقدمه: تشنج ناشی از تب، شایع‌ترین نوع تشنج است که 5-2 درصد کودکان آن را تجربه می‌نمایند. جستجوها نشان می‌دهد که مطالعات اولیه‌ی زیادی در خصوص عوامل مرتبط با تشنج ناشی از تب صورت گرفته است که در کنار هم قرار دادن نتایج آن‌ها بسیار ارزشمند است. بر همین اساس، در پژوهش حاضر با انجام یک مطالعه‌ی مرور ساختار یافته، عوامل مؤثر بر اولین تشنج ناشی از تب در کودکان ایرانی تعیین شد.روش‌ها: با استفاده از کلید واژه‌های Febrile seizure، Febrile convulsion، Children، Childhood، Fever، Iron deficiency و معادل فارسی آن‌ها و جستجو در پایگاه‌های اطلاعاتی ملی و بین‌المللی، نسبت به انتخاب مقالات اقدام شد. در ادامه با بهره‌گیری از ضوابط مربوط به مطالعات مرور ساختار یافته، مستندات مورد نظر وارد مطالعه شدند.یافته‌ها: از 28 مقاله‌ی وارد شده به این مرور ساختار یافته، 24 مطالعه از نوع مورد- شاهدی و 4 مطالعه از نوع مقطعی (توصیفی-تحلیلی) بود. تمرکز بیشتر مطالعات اولیه به ترتیب بر تعیین ارتباط بین سطح پلاسمای فریتین و کم خونی فقر آهن با تشنج ناشی از تب (8 مطالعه)، تعیین ارتباط بین سطح سرمی روی با تشنج ناشی از تب (7 مورد) و تعیین ارتباط بین سابقه‌ی فامیلی تب و تشنج با تشنج ناشی از تب در کودکان (7 مطالعه) بود.نتیجه‌گیری: بر نقش ژنتیک و سابقه‌ی فامیلی تب و تشنج، سطح سرمی روی و سن ابتلای 6 ماه تا 5 سال در پیش‌آگهی تشنج به دنبال تب، اتفاق نظر وجود داشته است؛ اما در ایجاد تب و تشنج، عوامل اتیولوژیک متعدد دیگری از قبیل عناصر کمیاب، مشکلات پری‌ناتال، سابقه‌ی فامیلی صرع، درجه‌ی حرارت بدن و ... نقش دارند که نیاز به مطالعات بیشتری با روش‌شناسی مناسب می‌باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Factors Cause the First Febrile Seizure in Children: A Systematic Review

نویسندگان [English]

  • Mohammad Mehdi Nasehi 1
  • Mahmood Moosazadeh 2
  • Sasan Saket 1
  • Mohammad kazem Bakhshandeh Bali 1
1 Fellowship, Department of Pediatric Neurology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 PhD Candidate, Department of Biostatistics and Epidemiology, School of Health, Mazandaran University of Medical Sciences, Sari, Iran
چکیده [English]

Background: Febrile seizure is the most common type of seizures which is experienced by 2 to 5 percent of children. Searches show that many primary studies have been performed on factors related to febrile seizure, putting whose results together is invaluable. Hence, the present study aimed to determine influential factors on the first febrile seizure among Iranian children, performing a systematic review.Methods: Primary studies were retrieved via searching national and international databases using relevant keywords of “febrile seizure”, “febrile convulsion”, “iron deficiency”, “fever”, “childhood”, “children” and their Persian equivalents. Following that, relevant documents were entered to the study using systematic review studies criteria.Findings: Twenty four, out of twenty eight, studies entered this systematic review, were case-control and the rest four were cross-sectional (descriptive-analytical) studies. Most of primary studies respectively focused on determining the relationship between serum ferritin level and iron deficiency anemia with the febrile seizure (8 studies), determining the relationship between zing serum level and the febrile seizure (7 studies), and determining the relationship between family history of fever and seizure with the febrile seizure (7 study) in children.Conclusion: There has been consensus on the role of genetics and family history of fever and seizure and age of 6 months to 5 years as the prognosis of seizures following fever. However, multiple etiologic factors, such as trace elements, perinatal complications, family history of epilepsy, body temperature and etc., play role in febrile seizures, which need further studies with appropriate methodology.

کلیدواژه‌ها [English]

  • Febrile seizure
  • Children
  • Trace element
  • Systematic Review

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مجله دانشکده پزشکی اصفهان
دوره 32، شماره 289 - شماره پیاپی 289
مرداد و شهریور 1393
صفحه 911-928

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سابقه مقاله

  • تاریخ دریافت: 18 مهر 1392
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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