The Effects of Hydroalcoholic Extract of Dracocephalum Kotschyi on Biochemical Blood Parameters in Diabetic Male Rats

Document Type : Original Article (s)

Authors

1 Associate Professor, Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran

2 Department of Physiology, School of Basic Sciences, Islamic Azad University, Fars Science and Research Branch, Shiraz, Iran

3 Assistant Professor, Department of Pediatrics, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

4 Student of Medicine, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

5 Associate Professor, Medicinal Plants Research Center AND Department of Physiology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

Abstract

Background: Diabetes mellitus is one of the most common endocrine diseases that impair the function of other body systems. This study conducted to determine the effect of hydro-alcoholic extract of Dracocephalum kotschyi on biochemical blood parameters of diabetic rats.Methods: In this experimental study, 48 male Wistar rats (215 ± 35 g) randomly were divided into 6 equal groups. Normal control and diabetic control groups received distilled water, and the control group receivedhydroalcoholic extract of Dracocephalum kotschyi (120 mg/Kg). Three treatment diabetic groups received 40, 80 and 120 mg/Kg of a hydroalcoholic extract of Dracocephalum kotschyi respectively. All groups were treated orally by gavage which continued for 21 days. The level of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), albumin, creatinine and urea nitrogen in blood was measured at the end of the study in different groups.Findings: The Mean blood glucose in the treatment groups with extract of Dracocephalum kotschyi decreased significantly compared to the diabetic control (P < 0.05). The mean of AST, ALT and ALP was significantly reduced in treating diabetic groups in comparison to the diabetic control (P < 0.05). The mean of albumin and urea nitrogen in the treatment groups with 80 and 120 mg/Kg of the extract were reduced significantly compared to the diabetic control (P < 0.05).Conclusion: The dosage of 80 and 120 mg/Kg extract of Dracocephalum kotschyi improve liver and kidney function in diabetic rat.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 379 - Serial Number 379
March and April 2016
Pages 401-407

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History

  • Receive Date: 18 January 2016
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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