The Comparison of the Effect of Handmade Del Nido and St. Thomas Cardioplegia Solutions on Quantitative Levels of Troponin I and Creatine Kinase-Myocardial Band (CPK-MB) in Repair of Pediatric Ventricular Septal Defect

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 MSc Student of Perfusion Science, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The most common cardioplegic solutions in pediatric cardiac surgery are Del Nido and St. Thomas. The aim of this study was to compare of the effect of these two solutions on cardiac protection, and prevention of myocardial injury during the aortic clamp time.Methods: This randomize clinical trial study was accomplished on 60 children under 12 years who were candidates for large ventral septal defect (VSD) repair surgery at Shahid Chamran hospital in Isfahan, Iran. One of handmade St. Thomas or Del Nido cardioplegic solutions was used randomly for electromechanical cardiac arrest in each children. Quantitative levels of cardiac troponin I and creatine kinase-myocardial band (CPK-MB) was measured and recorded before and 6 and 12 hours after the surgery.Findings: There was no significant difference between the two markers of troponin I and CPK-MB in both groups (P > 0.050). There was no difference regarding the duration of cardiopulmonary bypass (P = 0.120) and cardiac rhythm return time (P = 0.200) after removal of aortic clamp in both groups. The time of aortic clamp was significantly shorter in Del Nido group (P = 0.009).Conclusion: Due to the lack of statistically significant difference in quantitative levels of troponin I and CPK-MB between the two groups, it seems that efficiency of both solutions are similar.

Keywords

References

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Journal of Isfahan Medical School
Volume 38, Issue 567 - Serial Number 567
January and February 2020
Pages 147-153

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History

  • Receive Date: 15 August 2019
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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