بررسی ارتباط شدت سندرم پای بی‌قرار با نوع دیالیز و شاخص‌های خونی کلسیم، فسفر، هورمون پاراتیروئید و ویتامین D

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشجوی تخصص رشته‌ی داخلی، دانشگاه علوم پزشکی اصفهان، ایران

2 استادیار بیماری‌های کلیه (بالغین)، گروه داخلی، دانشگاه علوم پزشکی اصفهان، ایران

چکیده

مقاله پژوهشی




مقدمه: سندرم پای بی‌قرار (Restless leg syndrome) RLS یک عارضه‌ی شایع در در بیماری مزمن کلیه (Chronic kidney disease) CKD است. با توجه به مبهم بودن پاتوفیزیولوژی این عارضه، تأثیر روش دیالیز و ارتباط بین سطح سرمی پارامترهای خونی در شدت بروز RLS به خوبی مشخص نشده است. در این مطالعه ارتباط بین روش دیالیز و همچنین تأثیر شاخص‌های خونی کلسیم، فسفر، هورمون پاراتیروئید و ویتامین D برشدت سندرم پای بی‌قرار بررسی شد.
روش‌ها: در این مطلعه‌ی مقطعی، با مراجعه به بخش دیالیز بیمارستان الزهرا(س) و خورشید اصفهان تعداد 165 نفر بیمار همودیالیز و 110 نفر بیمار دیالیز صفاقی وارد مطالعه شدند. تشخیص و رتبه‌بندی سندرم پای بی‌قرار با استفاده از معیارهای بین‌المللی انجام شد، سپس پارامترهای میزان ویتامین D، کلسیم و فسفر و هورمون پاراتیروئید بر اساس نتایج آزمایشات ثبت و تحلیل گردید.
یافته‌ها: نتایج پژوهش حاضر بیانگر عدم تأثیر روش دیالیز در فراوانی و شدت بروز سندرم پای بی‌قرار می‌باشد. در این تحقیق مدل رگرسیون چندگانه در گروه همودیالیز و دیالیز صفاقی برازش مناسبی نداشت. بر اساس نتایج مقادیر همبستگی در در دو گروه میان متغیرهای کلسیم، PTH و فسفر سرم مثبت بود و رابطه‌ی ویتامین D با نمره‌ی سندرم پای بی‌قرار منفی معنی‌دار بود (0/05 > P).
نتیجه‌گیری: مدیریت و اندازه‌گیری‌های مکرر نشانگرهای بیوشیمیایی از جمله ویتامین D، P، Ca و PTH سرم خون، در بیماران مزمن کلیوی‐ اختلال معدنی و استخوان (CKD-MBD) نقش مؤثری در کاهش بروز سندرم پای بی‌قرار در بیماران CKD داشت.

تازه های تحقیق

الهام بابایی: Google Scholar, PubMed

سحر وحدت: Google Scholar, PubMed

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Investigating the Relationship between the Severity of Restless Leg Syndrome and the Type of Dialysis and Blood Parameters of Calcium, Phosphorus, Parathyroid Hormone, and Vitamin D

نویسندگان [English]

  • Elham Babaei 1
  • Sahar Vahdat 2
1 Medical Student Specializing in Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor of Kidney Diseases (Adults), Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Restless leg syndrome (RLS) is a common complication of chronic kidney disease (CKD). Due to the ambiguity of the pathophysiology of this condition, the effect of the dialysis method and the relationship between the serum level of blood parameters and the severity of RLS incidence have not been well defined. In this study; the relationship between the dialysis method and the effect of blood calcium, phosphorus, parathyroid hormone, and vitamin D on the severity of restless leg syndrome has been investigated.
Methods: In this cross-sectional study, 165 hemodialysis patients and 110 peritoneal dialysis patients were included by referring to the dialysis department of Al-Zahra and Khurshid Hospital in Isfahan. Restless leg syndrome was diagnosed and ranked using international criteria, then the parameters of vitamin D, calcium, phosphorus, and parathyroid hormone were recorded and analyzed based on the results of the tests.
Findings: The results of the present study show that the dialysis method does not affect the frequency and severity of restless leg syndrome. In this research, the multiple regression model did not fit well in the hemodialysis and peritoneal dialysis groups. Based on the results, the correlation values between calcium, PTH, and serum phosphorus variables in the two groups were positive, and the relationship between vitamin D and restless legs syndrome score was negative (P < 0.05).
Conclusion: Regularly monitoring biochemical markers such as vitamin D, phosphorus, calcium, and PTH levels in the blood serum of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) patients plays a crucial role in reducing the occurrence of restless leg syndrome in CKD patients.

کلیدواژه‌ها [English]

  • Restless legs syndrome
  • Hemodialysis
  • Peritoneal dialysis
  • Blood indicators
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