تأثیر عصاره‌ی گیاهان دارویی بر روی کرم‌های انگلی: یک مطالعه‌ی مروری نظام‌مند

نوع مقاله : مقاله مروری

نویسندگان

1 استادیار، مرکز تحقیقات داروهای گیاهی رازی، دانشگاه علوم پزشکی لرستان، خرم‌آباد، ایران

2 استادیار، گروه ژنتیک و بیولوژی مولکولی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی دزفول، دزفول، ایران

3 دانشیار، گروه ژنتیک و بیولوژی مولکولی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

4 استادیار، مرکز تحقیقات علوم بهداشتی و گروه علوم آزمایشگاهی، دانشکده‌ی پیراپزشکی، دانشگاه علوم پزشکی تربت حیدریه، تربت حیدریه، ایران

5 استادیار، مرکز تحقیقات هپاتیت و گروه ویروس‌شناسی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی لرستان، خرم‌آباد، ایران

6 گروه پاتوبیولوژی، دانشکده‌ی دام‌پزشکی، دانشگاه شهید چمران، اهواز، ایران

7 استادیار، مرکز تحقیقات بیماری‌های عفونی، دانشگاه علوم پزشکی گلستان، گرگان، ایران

چکیده

مقدمه: امروزه، عفونت‌های انگلی کرمی، یکی از مهم‌ترین مشکلات بهداشتی جهانی هستند. آلودگی‌های کرمی، سبب خسارت‌های جدی به صنعت دامداری می‌شود و همچنین، می‌تواند صدمات جبران ناپذیری به افراد دارای نقص ایمنی وارد نماید. بنابراین، هدف از انجام مطالعه‌ی حاضر، بررسی و مرور تحقیقات انجام شده بر روی درمان بیماری کرمی با استفاده از عصاره‌ی گیاهان دارویی بود.روش‌ها: در این مطالعه، جستجوی منابع در ۷ پایگاه داده شامل ۴ پایگاه داده‌ی انگلیسی (Scopus، PubMed، SienceDirect و Embase) و ۳ پایگاه داده‌ی فارسی (Scientific information database، Islamic World Science Citation Center و Magiran) بین سال‌های 2018-۲۰۰۸ و به زبان‌های فارسی و انگلیسی به منظور بررسی مطالعات صورت گرفته در رابطه با هدف مطالعه‌ی حاضر انجام شد.یافته‌ها: بیشتر مطالعات بر روی گیاه Balanites aegyptiaca (71/10 درصد) متمرکز بودند. همچنین، بیشترین روش مورد استفاده برای عصاره‌گیری، روش Maceration (57/78 درصد) و پس از آن، روش Sonication (14/7 درصد) بود. متانول، بیشترین (71/35 درصد) حلال مورد استفاده برای عصاره‌گیری و پس از آن، آب (85/17 درصد) بود. بیشترین انگل مطالعه شده، Haemonchus contortus (57/28 درصد) و پس از آن Schistosoma mansoni (71/10 درصد) بود.نتیجه‌گیری: مطالعات نشان دادند عصاره‌های گیاهان نسبت به داروهای سنتتیک می‌توانند جایگزین مناسبی برای کاهش اثرات کرمی در میزبان باشند و عصاره‌های گیاهی را می‌توان برای تولید داروهای مبتنی بر ترکیبات طبیعی و مؤثر بر علیه کرم‌ها با عوارض جانبی کمتر نسبت به داروهای سنتتیک مورد استفاده قرار داد.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Medicinal Plant Extracts on Helminthes: A Systematic Review

نویسندگان [English]

  • Kourosh Cheraghipour 1
  • Abbas Moridnia 2
  • Mohammadreza Sharifi 3
  • Mohammad Ali Mohaghegh 4
  • Sayyad Khanizadeh 5
  • Morteza Nourmohammadi 6
  • Hamed Kalani 7
1 Assistant Professor, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Assistant Professor, Department of Genetics and Molecular Biology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran
3 Associate Professor, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Assistant Professor, Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
5 Assistant Professor, Hepatitis Research Center AND Department of Virology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
6 Department of Pathobiology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
7 Assistant Professor, Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
چکیده [English]

Background: Currently, parasitic infections are the most important global health problems. Helminthic infections cause serious damage to the livestock industry. Most importantly, it can cause severe damage in immunocompromised individuals. The aim of this systematic review study was to assess the research on the treatment of helminthic diseases using medicinal plant extracts.Methods: The search was carried out in 7 databases including 4 English databases (Scopus, PubMed, SienceDirect, and Embase) and 3 Persian databases (Scientific Information Database, Islamic World Science Citation Center, and Magiran) in order to find the studies carried out in relation to the purpose of the current study between 2008 and 2018 in Persian and English languages.Findings: Most studies focused on Balanites aegyptiaca (10.71%). The most commonly used extraction method was maceration (78.57%) and then sonication (7.14%). Methanol (35.71%) was the most solvent used for extraction, followed by water (17.85%). The most studied parasite was Haemonchus contortus (28.57%), followed by Schistosoma mansoni (10.71%).Conclusion: Studies have shown that plant extracts can be a good alternative to synthetic drugs in reducing helminthic disease signs; and plant extracts can be used to produce drugs based on natural and effective compounds against helminthes with fewer side effects than synthetic drugs.

کلیدواژه‌ها [English]

  • Anthelmintics
  • Medicinal herbs
  • Systematic Review

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مجله دانشکده پزشکی اصفهان
دوره 37، شماره 525 - شماره پیاپی 525
خرداد و تیر 1398
صفحه 462-474

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  • تاریخ دریافت: 07 اردیبهشت 1398
  • تاریخ بازنگری: 12 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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