عناصر کمیاب خونی و شدت بیماری پارکینسون

معمار, رخساره; چیت‌ساز, احمد; آقای قزوینی, محمدرضا

عناصر کمیاب خونی و شدت بیماری پارکینسون

نوع مقاله : مقاله های پژوهشی

نویسندگان

¹ استادیار، گروه فارماکولوژی، دانشکده‌ی علوم پزشکی، دانشگاه آزاد اسلامی، واحد نجف‌آباد و عضو هیأت علمی پژوهشی، مرکز تحقیقات علوم اعصاب، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

² استاد، مرکز تحقیقات علوم اعصاب و گروه داخلی مغز و اعصاب، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

³ ایستگاه تحقیقات سلامت اصفهان، انستیتو ملی تحقیقات سلامت، دانشگاه علوم پزشکی تهران، تهران، ایران

چکیده

مقدمه: به نظر می‌رسد در پاتوژنز و پیشرفت بیماری پارکینسون که ماهیت تخریب کننده‌ی نورونی دارد، عناصر کمیاب نقش داشته باشند. هدف از این مطالعه بررسی سطح عناصر کمیاب مس، آهن و روی درچهار مرحله‌ی مختلف بیماری پارکینسون بود.روش‌ها: سطح سرمی عناصر کمیاب به روش بیوشیمیایی (902 Hitachi) در 109 بیمار مبتلا به پارکینسون اندازه‌گیری شد. شدت بیماری بر اساس روش HY (Hoehn and Yahr) در چهار مرحله (5/1-1 ،5/2-2 ،3 و 5-4) و همچنین قسمت حرکتی از مقیاس درجه‌بندی دیگری از پارکینسون (UPDRS III یا Unified Parkinson's diseases rating scale III) ارزیابی گردید.یافته‌ها: سطح سرمی تمامی عناصر کمیاب در محدوده‌ی طبیعی قرار داشت و تفاوت قابل ملاحظه‌ای بین مراحل مختلف HY وجود نداشت (آهن 670/0 = P، مس 540/0 = P و روی 340/0 = (P. بیماران با مرحله‌ی بالاتر بیماری، افراد مسن‌تری بودند (026/0 = P). وقتی که شدت بیماری پارکینسون با III UPRDS اندازه گیری شد، تنها ارتباط قابل ملاحظه‌ای بین سن و UPRDS مشاهده شد (024/0 = P).نتیجه‌گیری: تأثیر سن بیمار بر روی شدت بیماری در بیماران مشاهده شد، اما نقش عناصر کمیاب در روند بیماری اثبات نشد. برای یافتن ارتباط مشخص‌تر این عناصر کمیاب با بیماری پارکینسون، انجام مطالعات دقیق‌تری لازم است.

کلیدواژه‌ها

عنوان مقاله [English]

Trace Blood Elements and Severity of Parkinson’s Disease

نویسندگان [English]

Rokhsareh Meamar ¹
Ahmad Chitsaz ²
Mohammad Reza Aghaye-Ghazvini ³

¹ Assistant Professor, Department of Pharmacology, School of Medical Sciences, Islamic Azad University, Najafabad Branch AND Researcher, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

² Professor, Isfahan Neurosciences Research Center AND Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

³ Isfahan Health Research Station, National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran

چکیده [English]

Background: Parkinson's disease (PD) is a degenerative disorder of the nervous system and it seems that disturbances in trace elements homeostasis mediate progression of the disease. This study aimed to compare the levels of trace elements (Fe, Cu and Zn) in various stages of Parkinson's disease and to assess their correlation with the severity of the disease.Methods: Serum concentrations of trace elements were measured via Hitachi 902 biochemistry analysis in 109 patients with Parkinson's disease. Then, the severity of disease was evaluated and scored in four stages of 1-1.5, 2-2.5, 3, and 4-5 according to Hoehn and Yahr (HY) staging and also motor part of the Unified Parkinson’s Disease Rating Scale III (UPDRS III).Findings: All trace elements levels were within normal reference values and did not differ significantly between different Hoehn and Yahr stages (Fe: P = 0.670, Cu: P = 0.540, Zn: P = 0.340). Only patients with higher Hoehn and Yahr stages were older (P = 0.026). When the severity of Parkinson's disease was evaluated using UPDRS III, only there were significant association between age and the scale (P = 0.024).Conclusion: In this study, we confirmed only the age as a factor correlated with severity of Parkinson's disease. To clarify actual role of trace elements in this disease, more precise examination should be designed.

کلیدواژه‌ها [English]

Trace elements
Parkinson disease
Movement disorder
Severity

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