مروری بر شواهد موجود: بررسی ارتباط رزوراترول و دیابت

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی دکتری، مرکز تحقیقات امنیت غذایی، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 دانشیار، گروه تغذیه‌ی جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: رزوراترول به گروه بزرگی از ترکیبات بیولوژیک به نام فیتواستروژن‌ها تعلق دارد که فواید متعددی برای آن در بیماری‌های قلبی– عروقی، سرطان و بیماری‌های التهابی ذکر شده است. همچنین شواهد متناقضی هم در رابطه با اثرات مفید رزوراترول در درمان و پیشگیری از عوارض دیابت و چگونگی این اثر وجود دارد که در این مقاله‌ی مروری آن‌ها را بررسی می‌کنیم.روش‌ها: مقالات مربوط از بانک‏های اطلاعاتی Google scholar، PubMed، Scopus از سال 2000 تا سال 2010 مورد جستجو قرار گرفتند.نتیجه‌گیری: در اکثر مطالعات، اثرات مفید متعددی از رزوراترول در زمینه‌ی پیشگیری و درمان دیابت عنوان شده بود؛ اما احتمال‌ می‌رود همه‌ی مطالعات در حیوانات انجام شده است که پیشنهاد می‌گردد با توجه به اثرات احتمالی مشابه، مطالعات در انسان هم انجام شود. 

کلیدواژه‌ها

عنوان مقاله [English]

The Relationship between Resveratrol and Diabetes Mellitus

نویسندگان [English]

  • Omolbanin Kafeshani 1
  • Reza Ghiasvand 2
1 PhD Candidate, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran
2 Associate Professor, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran
چکیده [English]

Background: Resveratrol belongs to a large group of biologically active substances found in plants which are classified as phytoestrogen because of their ability to interact with estrogen receptors. Several beneficial effects of resveratrol are described in the literature such as cardioprotective, anti-cancer, anti-inflammatory and antioxidant actiosn. There are Conflicting evidence about the beneficial effects of resveratrol in treatment and prevention of diabetic complications. So, we decided to explore them in this review.Methods: Related articles from Google scholar, PubMed, Scopus databases from 2000 to 2010 were searched.Conclusion: Several useful effects of resveratrol in prevention and treatment of diabetes mellitus were recorded. However, almost all of the studies were conducted in animals that regarding the possible effects in human, similar studies should be proposed in them.

کلیدواژه‌ها [English]

  • Resveratrol
  • Diabetes
  • Insulin Resistance
  • Glucose metabolism
  • Insulin action

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مجله دانشکده پزشکی اصفهان
دوره 32، شماره 310 - شماره پیاپی 310
آذر و دی 1393
صفحه 1993-2005

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سابقه مقاله

  • تاریخ دریافت: 17 دی 1392
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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