Efficacy of Adding Topical Simvastatin to Topical Calcipotriol On Improvement of Cutaneous Plaque Psoriasis

Document Type : Original Article (s)

Authors

1 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran AND Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran

4 Assistant Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Psoriasis is a common dermatologic disorder, with fluctuating response to treatment. Considering the proven immunomodulatory effects of oral simvastatin in psoriasis, this study aimed to determine whether the topical form has also antipsoriatic effects. Vitamin D analogs known to be effective and are considered the first line of therapy in mild to moderate cases. In this study, the efficacy of topical calcipotriol 0.005% ointment (as a standard method of treatment for psoriasis), versus combination of calcipotriol plus topical simvastatin was compared in the treatment of psoriasis.Methods: 80 patients with symmetric psoriasis who had body surface involvement up to 20% were divided randomly into 2 groups. Group A were treated with calcipotriol 0.005% ointment twice daily and group B with calcipotriol 0.005% ointment twice daily and simvastatin 3% ointment twice daily, for 12 weeks. The results were evaluated by a blind dermatologist using psoriasis area severity index (PASI) score at baseline, 4th, 8th and 12th weeks of treatment. In a similar way, a subjective assessment performed by patients based on photo-evaluation at the end of the study.Findings: Despite a continuous reduction in PASI score in both groups, according to both physician (P = 0.603) and patient (P = 0.243) assessments, topical simvastatin was not statistically more effective than conventional treatment of psoriasis.Conclusion: This study indicates that topical simvastatin is not associated with significant impacts in the treatment of psoriasis as compared to oral form. This study indicates that psoriasis is a systemic disorder with variable skin manifestations. 

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 318 - Serial Number 318
November and December 2015
Pages 2378-2386

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History

  • Receive Date: 09 November 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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