چاقی و التهاب: نقش آدیپوکین‌ها

نوع مقاله : مقاله مروری

نویسندگان

1 دانشیار، مرکز تحقیقات التهاب نوروژنیک و گروه فیزیولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

2 استادیار، گروه پزشکی اجتماعی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

 با توجه به شیوع چاقی و افزایش عوارض ناشی از آن، شناخت عملکرد بافت چربی و عوامل مترشحه‌ی آن و اثرات آن‌ها بر بافت‌های مختلف بدن، بسیار ضروری به نظر می‌رسد. مطالعات اخیر نشان داده‌اند در چاقی یک التهاب مزمن خفیف (Chronic Low-grade inflammation) وجود دارد که می‌تواند در پاتوژنز عوارض ناشی از چاقی نقش داشته باشد. بافت چربی مقدار زیادی مواد ترشح می‌کند که به عنوان آدیپوکین شناخته می‌شوند. این مواد، می‌توانند اثرات مختلف پیش‌ التهابی یا ضد التهابی داشته باشند. پیشنهاد شده است عدم تعادل در ترشح آدیپوکین‌ها در افراد چاق، می‌تواند در ایجاد عوارض چاقی نقش داشته باشد. در این مقاله‌ی مروری، ارتباط چاقی و التهاب و نقش آدیپوکین‌ها در این فرایند پرداخته می‌شود.

کلیدواژه‌ها

عنوان مقاله [English]

Obesity and Inflammation: Role of Adipokines

نویسندگان [English]

  • Majid Khazaei 1
  • Reza Rouzbahani 2
1 Associate Professor, Neurogenic Inflammation Research Centre AND Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Because of the growing epidemic of obesity worldwide and its complications, understanding the function and secreted substances of adipose tissue and their effects on the body is very important. Obesity is characterized by what is called chronic low-grade inflammation which may be involved in pathogenesis of obesity-related complications. Adipose tissue releases multiple bioactive substances known as adipokines which have pro or anti-inflammatory actions. It is suggested that imbalances between production and secretion of adipokines during obesity can contribute to obesity-related complications. In this review, we discuss about inflammation during obesity and the role of adipokines in this process.

کلیدواژه‌ها [English]

  • Obesity
  • Inflammation
  • Adipokine

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مجله دانشکده پزشکی اصفهان
دوره 34، شماره 372 - شماره پیاپی 372
فروردین و اردیبهشت 1395
صفحه 148-156

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سابقه مقاله

  • تاریخ دریافت: 07 اردیبهشت 1394
  • تاریخ بازنگری: 12 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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