The Effect of 8 Weeks of Aerobic Training on Serum Levels of Interleukin-17, Adiponectin, and Estradiol in Women with Breast Cancer

Document Type : مقاله کوتاه

Authors

1 Assistance Professor, Department of Exercise Physiology, School of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan AND Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

2 Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Background: Today, breast cancer is most current cancer disease in women. The role of the aerobic training as preventive and adjuvant therapy in cancer is concerned. This study aimed to examine the effect of the aerobic training on the levels of interleukin-17 (IL-17), adiponectin and estradiol in women with breast cancer. Methods: 40 patients with breast cancer were randomly divided into two equal groups of exercise and control. The training group performed aerobic training for 8 weeks with intensity between 40 to 55 percent of target heart rate. 24 hours before the first and 48 hours after the last session of exercise protocol, blood samples were taken from both groups and serum levels of IL-17, adiponectin and estradiol were measured using enzyme-linked immunosorbent assay (ELISA).Findings: 8 weeks of aerobic exercise training increased adiponectin (P = 0.005) and decreased IL-17 (P = 0.015) and estradiol (P < 0.001) serum levels.Conclusion: The results of the present study suggested that levels of IL-17 and estradiol in response to aerobic training decreased but serum level of adiponectin as anti-inflammatory factor increased. ُSo, the exercise training can be an appropriate method for prevention and adjutant therapy in cancer.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 364 - Serial Number 364
November and December 2016
Pages 2263-2269

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History

  • Receive Date: 11 September 2015
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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