التهاب مزمن خفیف: علل و اثرات آن

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه فیزیولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

2 استادیار، گروه پزشکی اجتماعی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 استاد، مرکز تحقیقات التهاب نوروژنیک، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

چکیده

التهاب مزمن خفیف (Chronic low-grade inflammation) یافته‌ای پاراکلینیک است که امروزه در بسیاری از بیماری‌های شایع و مهم جوامع بشری مثل چاقی، دیابت، بیماری‌های عصبی و ... مشاهده می‌شود. به همین دلیل، مطالعات مختلفی بر روی علل و اثرات آن بر بدن در شرایط مختلف پاتولوژیک انجام و پیشنهاد شده است که التهاب مزمن خفیف در پاتوژنز ایجاد این بیماری‌ها یا عوارض آن‌ها نقش زیادی دارد. التهاب مزمن خفیف، با افزایش سطح لیپوپلی ‌ساکارید باکتریایی گرم منفی در گردش خون مشخص می‌شود که به دنبال آن، عوامل التهابی نیز افزایش می‌یابد. عوامل مختلفی ممکن است در ایجاد این التهاب نقش داشته باشند و به دنبال آن، التهاب نیز می‌تواند عوارض و عواقبی بر عملکرد قسمت‌های مختلف بدن داشته باشد. در این مقاله‌ی مروری به بررسی این علل و عوارض خواهیم پرداخت.

کلیدواژه‌ها

عنوان مقاله [English]

Chronic Low-Grade Inflammation: Etiology and its Effects

نویسندگان [English]

  • Fereshteh Asgharzadeh 1
  • Reza Rouzbahani 2
  • Majid Khazaei 3
1 MSc Student, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Professor, Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Chronic low-grade inflammation is a Para-clinical finding in several diseases including obesity, diabetes, nervous diseases and etc. Numerous studies have been done to determine the causes and effects of low-grade inflammation on the body. Today, chronic low-grade inflammation is considered in pathogenesis of these diseases. Chronic inflammation is reflected by increased circulating levels of gram-negative bacterial endotoxin lipopolysaccharide (LPS) which is associated by high level of inflammatory markers. Numerous factors can be involved in induction and progression of low-grade inflammation which lead to some consequences on different parts of body. In this review, we aimed to discuss about the causes and consequences of low-grade inflammation.

کلیدواژه‌ها [English]

  • Inflammation
  • Inflammatory markers
  • Lipopolysaccharide

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مجله دانشکده پزشکی اصفهان
دوره 34، شماره 379 - شماره پیاپی 379
خرداد و تیر 1395
صفحه 408-421

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  • تاریخ دریافت: 26 مهر 1394
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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