The Effect of Topical Avastin in the Success Rate of Dacryocystorhinostomy

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Ophthalmology, School of Medicine AND Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Resident, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Department of Ophthalmology, School of Medicine AND Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Resident, Department of Ophthalmology, School of Medicine AND Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Many factors are involved in the failure rate of dacryocystorhinostomy (DCR) surgery as the standard treatment of nasolacrimal duct obstruction. There is however, a lot of evidence that bevacizumab (Avastin) with less side effects, has the same anti-fibrosis effects. In this study we evaluated the effect of this drug on the failure rate of DCR.Methods: 60 candidates for DCR were divided to two groups each one containing 30 patients. These 2 groups were matched by age and sex. We used Avastin eye-drops (5 mg/ml) every 6 hours in one group for 2 weeks in addition to other post-op routine treatments. The patients were evaluated for failure of DCR 2 weeks and 3 months after surgery.Findings: In the Avasin group no patient showed surgery failure. In the other group, 1 patient in 2 week and 2 patients in 3 months follow-up showed failure. However this difference between 2 groups was not statistically significant and maybe due to small sample size. (P = 0.327, Fisher exact test).Conclusion: Avastin eye drop may lower the failure rate of DCR. This subject needs to be more evaluated in further studies.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 387 - Serial Number 387
May and June 2016
Pages 718-723

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History

  • Receive Date: 29 January 2016
  • Revise Date:
  • Accept Date: 06 April 2022

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