The Effects of Estrogen on Passive Avoidance Memory Impairment Induced by Acute Kidney Injury in Ovariectomized Rats

Document Type : Original Article (s)

Authors

1 MSc Student, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The aim of this study was to evaluate the effects of acute kidney injury (AKI) and mediatory role of the estrogen on passive avoidance memory in ovariectomized rats.Methods: Frothy ovariectomized Wistar rats were subjected to sham-vehicle, sham-estrogen, renal ischemia reperfusion (RIR)-vehicle, and RIR-estrogen groups. AKI was induced by ischemia reperfusion. Estrogen (200 μg/kg in 0.2 ml/100 g body weight) was injected subcutaneously once a week for four weeks. Then, passive avoidance memory was assessed.Findings: AKI resulted a significant decrease in the mean latency of entering the dark chamber (P < 0.010). Although, estrogen therapy following AKI led to elevated blood urea nitrogen (BUN) and creatinine, but, there was no significant difference in the delay in entering the dark chamber in RIR-estrogen group compared to RIR-vehicle group (P = 0.100).Conclusion: The results showed that AKI could have a deleterious effect on passive avoidance memory. However, the studied dose of estrogen cannot prevent passive avoidance memory impairment induced by AKI.

Keywords

References

  1. Seifter JL, Samuels MA. Uremic encephalopathy and other brain disorders associated with renal failure. Semin Neurol 2011; 31(2): 139-43.
  2. Bellomo R, Kellum JA, Ronco C. Acute kidney injury. Lancet 2012; 380(9843): 756-66.
  3. Liu M, Liang Y, Chigurupati S, Lathia JD, Pletnikov M, Sun Z, et al. Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol 2008; 19(7): 1360-70.
  4. Grams ME, Rabb H. The distant organ effects of acute kidney injury. Kidney Int 2012; 81(10): 942-8.
  5. Chou AH, Lee CM, Chen CY, Liou JT, Liu FC, Chen YL, et al. Hippocampal transcriptional dysregulation after renal ischemia and reperfusion. Brain Res 2014; 1582: 197-210.
  6. Zhang N, Cheng GY, Liu XZ, Zhang FJ. Expression of Bcl-2 and NF-kappaB in brain tissue after acute renal ischemia-reperfusion in rats. Asian Pac J Trop Med 2014; 7(5): 386-9.
  7. Shughrue PJ, Merchenthaler I. Estrogen is more than just a "sex hormone": Novel sites for estrogen action in the hippocampus and cerebral cortex. Front Neuroendocrinol 2000; 21(1): 95-101.
  8. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. Cardiovasc Res 2005; 67(4): 594-603.
  9. Muller V, Losonczy G, Heemann U, Vannay A, Fekete A, Reusz G, et al. Sexual dimorphism in renal ischemia-reperfusion injury in rats: Possible role of endothelin. Kidney Int 2002; 62(4): 1364-71.
  10. Takaoka M, Yuba M, Fujii T, Ohkita M, Matsumura Y. Oestrogen protects against ischaemic acute renal failure in rats by suppressing renal endothelin-1 overproduction. Clin Sci (Lond) 2002; 103(Suppl 48): 434S-7S.
  11. Meng X, Dai X, Liao TD, D'Ambrosio M, Wang F, Yang JJ, et al. Dose-dependent toxic effects of high-dose estrogen on renal and cardiac injury in surgically postmenopausal mice. Life Sci 2011; 88(3-4): 178-86.
  12. Fukuda K, Yao H, Ibayashi S, Nakahara T, Uchimura H, Fujishima M, et al. Ovariectomy exacerbates and estrogen replacement attenuates photothrombotic focal ischemic brain injury in rats. Stroke 2000; 31(1): 155-60.
  13. Lattenist L, Lechner SM, Messaoudi S, Le MA, El Moghrabi S, Prince S, et al. Nonsteroidal Mineralocorticoid receptor antagonist finerenone protects against acute kidney injury-mediated chronic kidney disease: Role of oxidative stress. Hypertension 2017; 69(5): 870-8.
  14. Akbari E, Motamedi F, Naghdi N, Noorbakhshnia M. The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task. Behav Brain Res 2008; 187(1): 172-7.
  15. Kovalcikova A, Gyuraszova M, Vavrincova-Yaghi D, Vavrinec P, Tothova L, Boor P, et al. Oxidative stress in the brain caused by acute kidney injury. Metab Brain Dis 2018; 33(3): 961-7.
  16. Lu R, Kiernan MC, Murray A, Rosner MH, Ronco C. Kidney-brain crosstalk in the acute and chronic setting. Nat Rev Nephrol 2015; 11(12): 707-19.
  17. Sutton TA. Alteration of microvascular permeability in acute kidney injury. Microvasc Res 2009; 77(1): 4-7.
  18. Tahamtan M, Sheibani V, Shid Moosavi SM, Asadi-Shekaari M, Esmaeili-Mahani S, Aghaei I, et al. Pre-Treatment with erythropoietin attenuates bilateral renal ischemia-induced cognitive impairments. Iran J Pharm Res 2018; 17(2): 601-12.
  19. Iran-Nejad A, Nematbakhsh M, Eshraghi-Jazi F, Talebi A. Preventive role of estradiol on kidney injury induced by renal ischemia-reperfusion in male and female rats. Int J Prev Med 2015; 6: 22.
  20. Mankhey RW, Bhatti F, Maric C. 17beta-Estradiol replacement improves renal function and pathology associated with diabetic nephropathy. Am J Physiol Renal Physiol 2005; 288(2): F399-F405.
  21. Ahmed SB, Culleton BF, Tonelli M, Klarenbach SW, Macrae JM, Zhang J, et al. Oral estrogen therapy in postmenopausal women is associated with loss of kidney function. Kidney Int 2008; 74(3): 370-6.
  22. Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-
  23. derived dendritic cells. Blood 2004; 104(5): 1404-10.
  24. Asai K, Hiki N, Mimura Y, Ogawa T, Unou K, Kaminishi M. Gender differences in cytokine secretion by human peripheral blood mononuclear cells: Role of estrogen in modulating LPS-induced cytokine secretion in an ex vivo septic model. Shock 2001; 16(5): 340-3.
  25. Wang Y, Cela E, Gagnon S, Sweezey NB. Estrogen aggravates inflammation in Pseudomonas aeruginosa pneumonia in cystic fibrosis mice. Respir Res 2010; 11: 166.
  26. Gibbs RB. Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol Aging 2000; 21(1): 107-16.
  27. O'Neal MF, Means LW, Poole MC, Hamm RJ. Estrogen affects performance of ovariectomized rats in a two-choice water-escape working memory task. Psychoneuroendocrinology 1996; 21(1): 51-65.
Journal of Isfahan Medical School
Volume 37, Issue 515 - Serial Number 515
January and February 2019
Pages 86-92

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History

  • Receive Date: 12 December 2018
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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